Risk factors of the peptic ulcer bleeding in aging uremia patients under regular hemodialysis

Lin, Xi-Hsuan; Lin, Chung‐Chi; Wang, Yuan‐Jen; Luo, Jiing‐Chyuan; Young, Shih‐Hao; Chen, Ping‐Hsien; Hou, Ming‐Chih; Lee, Fa-Yauh

doi:10.1016/j.jcma.2018.03.007

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…75 Severely ill and people with chronic illness, whereas aging hemodialysis patients had significantly higher incidences of PUB than the matched controls. 64 And also co morbidity in patients diagnosed with hypoalbuminemia has a significantly elevated risk of developing PUB.…”

Section: Discussionmentioning

confidence: 99%

Risk factors leading to peptic ulcer disease: systematic review in literature

Asali¹,

Alghamdi²,

Fallatah³

et al. 2018

Int J Community Med Public Health

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This review is aiming to discuss the risk factors which lead to the occurrence of PUD during the period from July 2018 to August 2018. The present review was conducted by searching in Medline, Embase, Web of Science, Science Direct, BMJ journal and Google Scholar for, researches, review articles and reports, published over the past years. Books published on peptic ulcers and on the pathogenesis of human disease were also included., were searched up to August 2018 for published and unpublished studies and without language restrictions, the selected studies were summarized and un reproducible studies were excluded. If several studies had similar findings, we randomly selected one or two to avoid repetitive results. On the basis of findings and results this review found the H. Pylori and the use of NSAIDs are the most common risk factors for developing PUD, and also the genetic, stress and comorbidity increase the risk of PUD occurrence so successful eradication and prevention of the risk factors should be conducted to prevent the presence of PUD and is complication.

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Section: Discussionmentioning

confidence: 99%

Risk factors leading to peptic ulcer disease: systematic review in literature

Asali¹,

Alghamdi²,

Fallatah³

et al. 2018

Int J Community Med Public Health

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“…Epidemiological studies revealed an increased susceptibility to major bleeding events in dialysis patients [320,321]. Potential etiologies include platelet dysfunction, dysfunctional von Willebrand factor, decreased production of thromboxane, uremic toxins, and anemia [322,323].…”

Section: Uremic Coagulopathymentioning

confidence: 99%

Estrogen and estrogen receptors in kidney diseases

Chen

2021

Renal Failure

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Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney. For instance, they are crucial in maintaining mitochondrial homeostasis and modulating endothelin-1 (ET-1) system in the kidney. Estrogen takes part in the kidney repair and regeneration via its receptors. Estrogen also participates in the regulation of phosphorus homeostasis via its receptors in the proximal tubule. The ERa polymorphisms have been associated with the susceptibilities and outcomes of several renal diseases. As a consequence, the altered or dysregulated estrogen/ERs signaling pathways may contribute to a variety of kidney diseases, including various causes-induced AKI, diabetic kidney disease (DKD), lupus nephritis (LN), IgA nephropathy (IgAN), CKD complications, etc. Experimental and clinical studies have shown that targeting estrogen/ERs signaling pathways might have protective effects against certain renal disorders. However, many unsolved problems still exist in knowledge regarding the roles of estrogen and ERs in distinct kidney diseases. Further research is needed to shed light on this area and to enable the discovery of pathwayspecific therapies for kidney diseases.

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“…Studies report that patients with end-stage renal disease (ESRD), through a cluster of complex pathophysiological mechanisms, are at a higher risk of bleeding peptic ulcers than the general population [ 6 , 7 ]. A higher rate of hemodialysis utilization, which is independently associated with a higher occurrence of PUB, has also been reported in the US population and may amplify the rate of PUB [ 7 ].…”

Section: Introductionmentioning

confidence: 99%