Risk Factors of Postoperative Nosocomial Pneumonia in Stage I-IIIa Lung Cancer Patients

Zeng, Wang; Cai, Xiaoxiao; Shi, Liang; Li, Fei-Yan; Lin, Nengming

doi:10.7314/apjcp.2014.15.7.3071

Cited by 23 publications

(33 citation statements)

References 25 publications

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“…A previous study (Lee, 2008) identified the 45-64 year age bracket as the group most likely to develop VAP; a foreign report (Tablan et al, 2004) also identified infants and the elderly (≥ 65 years) as groups most vulnerable to VAP, also consistent with the results of this study, although this study included only patients greater than 18 years of age. In this study, patients aged 65 years or more were found to be have risk of VAP in 5.56 times(p=0.021), patients with lung cancer were found to be 5.81 times (Wang et al, 2014) compared to patients aged 60 years or more (p=0.018).…”

Section: Discussionmentioning

confidence: 55%

Factors Influencing Ventilator-Associated Pneumonia in Cancer Patients

Park

Cho²,

Kwak³

2014

Asian Pacific Journal of Cancer Prevention

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Background: With increasing survival periods and diversification of treatment methods, treatment of critically ill cancer patients has become an important factor influencing patient prognosis. Patients with cancer are at high risk of infections and subsequent complications. This study investigated the incidence and factors contributing to the development of ventilator-associated pneumonia (VAP). Materials and Methods: This retrospective study investigated the incidence of VAP and factors leading to infection in patients admitted to the intensive care unit (ICU) of a cancer center from January 1, 2012 to December 31, 2013. Results: The incidence of VAP was 2.13 cases per 1,000 days of intubation, and 13 of 288 patients (4.5%) developed VAP. Lung cancer was the most common cancer associated with VAP (N=7, 53.9%), and longer hospital stays and intubation were associated with increased VAP incidence. In the group using a "ventilator bundle," the incidence was 1.14 cases per 1,000 days compared to 2.89 cases per 1,000 days without its use; however, this difference was not statistically significant (p=0. The incidence of pneumonia among critically ill cancer patients is highest in those with lung cancer, but lower than among non-cancer patients. The length of hospital stay and time on mechanical ventilation are important risk factors for development of VAP. Although not statistically significant, "ventilator bundle" care is an effective intervention that delays or reduces incidence of VAP. Major risk factors for VAP include age (≥ 65 years), surgery, and tracheostomy, while fungi, gram-negative bacteria, and multidrug-resistant organisms were identified as the major causative pathogens of VAP in this study.

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Section: Discussionmentioning

confidence: 55%

Factors Influencing Ventilator-Associated Pneumonia in Cancer Patients

Park

Cho²,

Kwak³

2014

Asian Pacific Journal of Cancer Prevention

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“…A retrospective study by Simonsen et al [44] looked at 7479 lung cancer surgery patients, finding 3.6% of them developed pneumonia postoperatively. Similarly, a retrospective study by Wang et al [45] studied 511 patients who underwent lung resection for cancer. They found 2.9% of patients developed postoperative pneumonia.…”

Section: Resultsmentioning

confidence: 99%

“…Patients who underwent open thoracotomy had the highest risk of postoperative pneumonia (aOR: 1.79; 95% CI: 1.02 - 3.17). Wang et al [45] found age > 60 years was a significant independent risk factor (OR: 5.813; P = 0.018), as was squamous cell carcinoma histopathology (OR: 5.831; P < 0.001). Preoperative COPD (OR: 0.031; 95% CI: 0.012 - 0.078; P < 0.001) and WBC count (OR: 1.451; 95% CI: 1.212 - 1.736; P < 0.001) were identified as independent risk factors by Lai et al [47].…”

Section: Resultsmentioning

confidence: 99%

The Epidemiology and Risk Factors for Postoperative Pneumonia

et al. 2017

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Postoperative pneumonia is a common complication of surgery, and is associated with marked morbidity and mortality. Despite advances in surgical and anesthetic technique, it persists as a frequent postoperative complication. Many studies have aimed to assess its burden, as well as associated risk factors. However, this complication varies among the different surgical specialties, and there is a paucity of reports that comprehensively evaluate this complication. Therefore, the purpose of this study was to review the epidemiology and risk factors of postoperative pneumonia in the setting of: 1) general surgery; 2) cardiothoracic surgery; 3) orthopedic and spine surgery; and 4) head and neck surgery.

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“…Actually, there are limited data on the incidence of postoperative pneumonia (POP) following major cancer surgery. The incidence of POP after lung cancer surgery ranged from 2.1% to 10.7% [4][5][6][7][8][9][10][11], after gastric cancer surgery 3.6% to 4.3% [12,13], and after colorectal cancer surgery 6.2% [14]. To our knowledge, however, there have been few studies conducted on the incidence of POP after surgery in other cancers or comparative analyses of the incidence of various cancer types.…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors of postoperative pneumonia following cancer surgery in adult patients with selected solid cancer: results of “Cancer POP” study

et al. 2017

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The aim of this study was to investigate the incidence and risk factors of postoperative pneumonia (POP) within 1 year after cancer surgery in patients with the five most common cancers (gastric, colorectal, lung, breast cancer, and hepatocellular carcinoma [HCC]) in South Korea. This was a multicenter and retrospective cohort study performed at five nationwide cancer centers. The number of cancer patients in each center was allocated by the proportion of cancer surgery. Adult patients were randomly selected according to the allocated number, among those who underwent cancer surgery from January to December 2014 within 6 months after diagnosis of cancer. One‐year cumulative incidence of POP was estimated using Kaplan–Meier analysis. An univariable Cox's proportional hazard regression analysis was performed to identify risk factors for POP development. As a multivariable analysis, confounders were adjusted using multiple Cox's PH regression model. Among the total 2000 patients, the numbers of patients with gastric cancer, colorectal cancer, lung cancer, breast cancer, and HCC were 497 (25%), 525 (26%), 277 (14%), 552 (28%), and 149 (7%), respectively. Overall, the 1‐year cumulative incidence of POP was 2.0% (95% CI, 1.4–2.6). The 1‐year cumulative incidences in each cancer were as follows: lung 8.0%, gastric 1.8%, colorectal 1.0%, HCC 0.7%, and breast 0.4%. In multivariable analysis, older age, higher Charlson comorbidity index (CCI) score, ulcer disease, history of pneumonia, and smoking were related with POP development. In conclusions, the 1‐year cumulative incidence of POP in the five most common cancers was 2%. Older age, higher CCI scores, smoker, ulcer disease, and previous pneumonia history increased the risk of POP development in cancer patients.

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Risk Factors of Postoperative Nosocomial Pneumonia in Stage I-IIIa Lung Cancer Patients

Cited by 23 publications

References 25 publications

Factors Influencing Ventilator-Associated Pneumonia in Cancer Patients

Factors Influencing Ventilator-Associated Pneumonia in Cancer Patients

The Epidemiology and Risk Factors for Postoperative Pneumonia

Incidence and risk factors of postoperative pneumonia following cancer surgery in adult patients with selected solid cancer: results of “Cancer POP” study

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