Risk factors of Pancreatic Cancer in Vietnam: A Matched Case–Control Hospital-Based Study

Abstract

Background: Data about the risk factors and pancreatic cancer in developing countries remain limited. We investigated for the first time the role of a number of risk factors (family cancer history, smoking, alcohol consumption, diabetes, inflammation disease, HBV infection) associated with pancreatic cancer among Vietnamese patients. Methods: We included all patients hospitalized at 4 Northern Vietnamese hospitals (Vietnam National Cancer Hospital, Bach Mai, Viet Duc, Thai Nguyen) and diagnosed with pancreatic cancer during the period from 2017 to 2019. Risk factors of eligible patients were collected and assessed the associations using a matched control study and logistic regression model analysis. Results: We identified 196 patients with diagnosis of pancreatic cancer of which 114 males and 82 females. The average age of the patient at the time of diagnosis was 58.28 years (standard deviation of 12.94, ranging from 25 to 87). Most of patients were diagnosed at advanced stage (85%). Smoking, diabetes, inflammation disease significantly increased the cancer risks (OR and 95% CI were 2.42 (1.38-4.37), 3.09 (1.54-6.68), 2.21 (1.42-3.45), respectively). HBV infection demonstrated a significant link with pancreatic cancer in univariate model (OR = 2.94 (1.08-9.36)), but not in multivariate model. However, cancer family history and alcohol drinkers did not show any significantly increased risk related to pancreatic cancer. Conclusions: Our finding showed smoking, diabetes, inflammation disease significantly increased the risk of pancreatic cancer in Vietnam.

Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects

“…Van Tran T. and his research team evaluated 196 Vietnamese patients (114 males and 82 females) diagnosed with PC regarding family cancer history, smoking, alcohol consumption, diabetes, inflammation disease, and HBV infection [ 68 ]. The study concluded that diabetes, smoking, and inflammation diseases are correlated with an elevated risk of PC [ 68 ].…”

miR-146a Inhibited Pancreatic Cancer Cell Proliferation by Targeting SOX7

“…Pancreatic cancer (PC) is defined as a malignancy at digestive tract, featured by insidious initiation and rapid progression [ 1 , 2 ]. Besides, it has become a significant health problem because it is one of the most frequently diagnosed tumors in humans and the important cause of cancer-related death in humans for a long time [ 3 ].…”

Incidence and risk factors of pancreatic cancer during 15 years follow-up in the Golestan Cohort Study in Iran

“…also men had lower survival rates significantly compared to women but the male gender, with a 0.853 HR, was not considered a risk factor for PC. In this line, a study from Israel considered the HR of gender in PC not statistically significant, and PC incidence did not differ between men and women [14]. In contrast, some studies showed that the prevalence of PC in men is higher than in women [15,16].…”

“…research between former smokers and those who had never smoked. Additionally, PC risk rose among smokers who smoked more cigarettes per day and for longer than 50 years [4,14,15]. Other studies considered that current smokers had a greater chance of developing PC than non-smoker people [16,17,20,21].…”