Risk factors of occult malignancy in patients with unprovoked venous thromboembolism

Robin, Philippe; Roux, Pierre‐Yves Le; Tromeur, Cécile; Planquette, Benjamin; Prévôt-Bitot, Nathalie; Lavigne, Christian; Pastré, Jean; Merah, Adel; Couturaud, Francis; Gal, Grégoire Le; Salaun, Pierre–Yves

doi:10.1016/j.thromres.2017.08.021

Cited by 17 publications

(11 citation statements)

References 15 publications

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“…32 In a post hoc analysis of the MVTEP study, age of 50 years or older, male sex, leukocytosis (≥10 g/l), and thrombocytosis (≥350 g/l) were associated with increased rates of occult cancer detection. 33 The risk of cancer was 12.9% in patients with leukocytosis and 15.4% in those with thrombocytosis, which was much higher than the risk of 6.4% in the whole study population. The type of VTE (pulmonary embolism or deep vein thrombosis), medical history (oral contraceptive use, family history of cancer, previous cancer history, prior VTE, smoking status, alcohol intoxication, asbestos exposure, asthenia, and anorexia), hemoglobin and hematocrit levels, and liver function tests were not associated with occult cancer detection.…”

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confidence: 65%

Occult cancer and thromboembolism: current epidemiology and its practical implication

Chao¹,

Wang²,

Kao³

2018

Polish Archives of Internal Medicine

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Venous thromboembolism (VTE) may be the first presentation of malignancy. Up to 10% of patients with unprovoked VTE are diagnosed with occult cancer within 1 year. Cancer patients with concomitant VTE have a worse outcome. While limited screening strategy (thorough medical history, physical examination, basic laboratory tests, and chest X‑ray) and extensive screening strategy (limited screening plus computed tomography scan of the abdomen/pelvis or 18F-fluorodeoxyglucose positron emission tomography-computed tomography) have a similar ability to detect early-stage cancer and improve morbidity and mortality of cancer patients with unprovoked VTE, the extensive screening strategy has been shown to diagnose occult cancer earlier. Among the risk factors for occult cancer in patients with unprovoked VTE, age is the most promising one. The risk of occult cancer detection increases with age. The newly developed RIETE score helps identify risk of occult cancer and might decrease unnecessary diagnostic procedures in lower-risk patients. Current guidelines suggest that patients with first unprovoked VTE undergo limited screening, with age- and sex-specific cancer screening, including colon, breast, cervical, and prostate cancers.

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confidence: 65%

Occult cancer and thromboembolism: current epidemiology and its practical implication

Chao¹,

Wang²,

Kao³

2018

Polish Archives of Internal Medicine

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“…Among these characteristics are recurrent VTE despite adequate anticoagulant treatment, bilateral deep vein thrombosis and extensive pulmonary embolism. A recent study evaluated the data from the MVTEP trial and identified the following as risk factors for occult cancer in unprovoked VTE patients: age >50 years, male sex, high leukocyte counts and high platelet count [57]. Surprisingly, smoker status and history of previous VTE were not associated with occult cancer diagnosis.…”

Section: Special Issues In Catmentioning

confidence: 99%

Cancer-associated thrombosis: the when, how and why

et al. 2019

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Cancer-associated thrombosis (CAT) is a condition in which relevance has been increasingly recognised both for physicians that deal with venous thromboembolism (VTE) and for oncologists. It is currently estimated that the annual incidence of VTE in patients with cancer is 0.5% compared to 0.1% in the general population. Active cancer accounts for 20% of the overall incidence of VTE. Of note, VTE is the second most prevalent cause of death in cancer, second only to the progression of the disease, and cancer is the most prevalent cause of deaths in VTE patients. Nevertheless, CAT presents several peculiarities that distinguish it from other VTE, both in pathophysiology mechanisms, risk factors and especially in treatment, which need to be considered. CAT data will be reviewed in this review.

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“…Several clinical and analytical factors have revealed a predictive value for the identification of patients with uVTE at increased risk of cancer [14][15][16][17]. The Computerized Registry of Patients with Venous Thromboembolism (RIETE) score was validated for this purpose, with the highest risk being present in patients who meet three or more of the following criteria: male gender, age equal or superior to 70 years, chronic lung disease, anemia, thrombocytosis, previous VTE and recent surgery [18].…”

Section: Introductionmentioning

confidence: 99%

Cancer Screening in Patients with Unprovoked Thromboembolism: How to do it and Who Benefits?

Ferreira¹,

Pereira²,

Lynce³

et al. 2020

Cureus

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Risk factors of occult malignancy in patients with unprovoked venous thromboembolism

Cited by 17 publications

References 15 publications

Occult cancer and thromboembolism: current epidemiology and its practical implication

Occult cancer and thromboembolism: current epidemiology and its practical implication

Cancer-associated thrombosis: the when, how and why

Cancer Screening in Patients with Unprovoked Thromboembolism: How to do it and Who Benefits?

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