Cancer Screening in Patients with Unprovoked Thromboembolism: How to do it and Who Benefits?

Ferreira, Filipa; Pereira, José Paulo; Lynce, Ana; Marques, José Nunes; Martins, Ana

doi:10.7759/cureus.6934

Cited by 3 publications

(3 citation statements)

References 24 publications

(51 reference statements)

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“…This finding raises the question of whether screening patients with venous thromboembolism for underlying cancer would be beneficial. Multiple studies investigated screening protocols regarding unprovoked VTEs and looked at limited screening (blood count, kidney function, ionogram, and chest x-ray) versus extended screening (ultrasound, CT, positron emission tomography (PET)/CT, endoscopy) [14,15]. In the study conducted by Ferreira et al, they developed a protocol that looks at patient risk factors, clinical history, physical examination, general laboratory results, imaging results, and Registro Informatizado Enfermedad TromboEmbólica (RIETE) score to determine if a patient should undergo limited or extended screening following unprovoked VTE [15].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies investigated screening protocols regarding unprovoked VTEs and looked at limited screening (blood count, kidney function, ionogram, and chest x-ray) versus extended screening (ultrasound, CT, positron emission tomography (PET)/CT, endoscopy) [14,15]. In the study conducted by Ferreira et al, they developed a protocol that looks at patient risk factors, clinical history, physical examination, general laboratory results, imaging results, and Registro Informatizado Enfermedad TromboEmbólica (RIETE) score to determine if a patient should undergo limited or extended screening following unprovoked VTE [15]. While this approach may aid in the earlier identification of patients with cancer, it may not detect cancer in the absence of a primary lesion unless a PET scan is utilized in the screening process.…”

Section: Discussionmentioning

confidence: 99%

“…While this approach may aid in the earlier identification of patients with cancer, it may not detect cancer in the absence of a primary lesion unless a PET scan is utilized in the screening process. Therefore, the benefits and drawbacks of screening, such as cost and radiation exposure, would need to be further investigated, as suggested in previous studies [14,15].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent Thromboembolic Events While on Anticoagulation Lead to the Diagnosis of Metastatic Lung Adenocarcinoma: A Case Report

Brubaker¹,

Sooklal²

2023

Cureus

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Lung cancer can lead to hypercoagulability that causes thromboembolic events such as pulmonary emboli, deep vein thrombosis, ischemic strokes, and non-bacterial thrombotic endocarditis. While it is not uncommon for cancer to cause thromboembolic events, it is unusual for thrombotic events to be the first manifestation of cancer. In the following report, we review the case of a 59-year-old woman who presented with melena and abdominal pain. She had a pertinent history of multiple thromboembolisms while on anticoagulation four months before this presentation. Upon admission, it was discovered that the patient had new pulmonary emboli, and further workup revealed that her gastrointestinal symptoms were due to ischemic colitis. While initial imaging showed no evident masses that would heighten suspicion of cancer, she had persistent abdominal lymphadenopathy. Therefore, she also underwent an abdominal lymph node biopsy which revealed metastatic lung adenocarcinoma, a possible cause of her hypercoagulable state. This case report highlights the importance of considering malignancy in the differential of a patient with recurrent thromboembolism and raises the question of whether standardized screening for malignancy in patients with multiple thromboembolic events would be beneficial.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrent Thromboembolic Events While on Anticoagulation Lead to the Diagnosis of Metastatic Lung Adenocarcinoma: A Case Report

Brubaker¹,

Sooklal²

2023

Cureus

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Fake-news-free evidence-based communication for proper vein-lymphatic disease management

Gianesini

Chi

Agüero³

et al. 2023

Int Angiol

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Case report of a pulmonary embolism in a patient with inferior vena cava compression by an 11 × 28 cm abdominal benign tumor

Morr,

Sabbagh,

Rosin

et al. 2024

EJMCR

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Background: Pulmonary embolism (PE) is a life-threatening condition causing an abrupt reduction in blood flow in the pulmonary vasculature due to a migrating thrombus. The most cases are related to thromboembolism events originating in the lower limbs. However alternate etiologies should be suspected in certain clinical cases mainly in young patients with no risk factors. Case Presentation: We present a case of a young patient with proximal PE caused by compression on the inferior vena cava by an abdominal benign tumor measuring 11 × 28 cm. The patient was treated surgically and started on a therapeutic dose of Anticoagulation. The etiology of PE in this case was attributed to large vein compression promoting blood stasis and leading to thrombus formation. Conclusion: In short, acute PE in young female patients, is unusual and should raise suspicion for miscellaneous causes including vascular compression by tumors.

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Cancer Screening in Patients with Unprovoked Thromboembolism: How to do it and Who Benefits?

Cited by 3 publications

References 24 publications

Recurrent Thromboembolic Events While on Anticoagulation Lead to the Diagnosis of Metastatic Lung Adenocarcinoma: A Case Report

Recurrent Thromboembolic Events While on Anticoagulation Lead to the Diagnosis of Metastatic Lung Adenocarcinoma: A Case Report

Fake-news-free evidence-based communication for proper vein-lymphatic disease management

Case report of a pulmonary embolism in a patient with inferior vena cava compression by an 11 × 28 cm abdominal benign tumor

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