Risk factors of late-onset neonatal sepsis in Taiwan: A matched case-control study

Kung, Yin-Hsiang; Hsieh, Y. F.; Weng, Yi Ming; Lien, Reyin; Luo, Jian; Wang, Yuan; Huang, Yhu-Chering; Chen, Chyi‐Liang; Chen, Chih‐Jung

doi:10.1016/j.jmii.2013.10.001

Cited by 30 publications

(33 citation statements)

References 20 publications

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“…CoNS was the most commonly isolated pathogen during the 1992e2001 and 2008e2013 periods in our NICU, similar to other reports from Taiwan. 3,4,12 Because of the high proportion of CoNS infection, Gram-positive organisms were the dominant pathogens in our NICU. CoNS BSI may be related to prolonged central line catheter use.…”

Section: Discussionmentioning

confidence: 99%

“…Preterm and VLBW infants often require aggressive interventions, such as mechanical ventilator, intravascular catheterization, parenteral nutrition supplement, and prolonged length of hospitalization. 11,12 Late-onset infection is associated with all these managements. Although the ratio of these more vulnerable patients remained high, better outcome was found through the years.…”

Section: Discussionmentioning

confidence: 99%

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Changing of bloodstream infections in a medical center neonatal intensive care unit

Chen

Chiu

Chi

et al. 2017

Journal of Microbiology, Immunology and Infection

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Changing of bloodstream infections in a medical center neonatal intensive care unit

Chen

Chiu

Chi

et al. 2017

Journal of Microbiology, Immunology and Infection

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“…16 A retrospective, matched, caseecontrol study performed on 164 Taiwanese case infants with bloodstream infections and as many controls showed that parenteral nutrition (OR 6.07; 95% CI, 1.14e32.32; p Z 0.034) and intraventricular hemorrhage (OR, 2.68; 95% CI, 1.20e5.99; p Z 0.017) were independently associated with bloodstream infections after multivariate analysis. 17 Moreover, a retrospective United States (US) cohort study, evaluating NICUs patients with peripherally inserted central catheters from 2003 to 2010, showed that catheter removal due to adverse events is significantly associated with LOS and that antibiotic use before removal is not associated with a decline in sepsis rate. 18…”

Section: Losmentioning

confidence: 99%

Early and Late Infections in Newborns: Where Do We Stand? A Review

Cortese

Scicchitano

Gesualdo

et al. 2016

Pediatrics & Neonatology

228

165

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Neonatal sepsis still represents an important cause of mortality and morbidity among infants. According to the onset, we can distinguish "early onset sepsis" when microbiological cultures positive for external pathogens come from newborns during the first 7 days of life (maternal intrapartum transmission); "late onset sepsis" when microbiological cultures positive for external pathogens come from newborns after the first 7 days from delivery (postnatal acquisition). In this review we synthesize the incidence, risk factors, clinical manifestations, and methods of diagnosis and treatment of each type of neonatal infection, in order to better define such a pathological condition which is of great importance in common clinical practice.

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“…Kung et al [35] affirm that infants in NICU have a higher incidence of Candida infections than any other pediatric or adult population. The predisposing factors were evaluated in Taiwan using a retrospective matched case-control study conducted in the NICUs of a teaching hospital from July 2003 to June 2006.…”

Section: Neonatal Candida Infectionsmentioning

confidence: 99%

Fungal Infections in Neonatal Intensive Care

Neves¹,

Parahym²,

daSilva³

et al. 2018

Selected Topics in Neonatal Care

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Neonates represent a unique and highly vulnerable patient population. Advances in medical technology have improved the survival and quality of life of newborns, particularly those with extreme prematurity or with congenital defects. Furthermore, immunologic immaturity and altered cutaneous barriers play some role in the vulnerability of neonates to nosocomial infections. In this context, the incidence of invasive fungal infections has increased significantly worldwide, representing an important infective complication in patients hospitalized in intensive care units. Invasive fungal infections in Neonatal Intensive Care Unit (NICUs) show high mortality; being species of Candida, the most isolates etiologic agents. The better prognosis of the patient is associated with the early diagnosis and fast treatment. However, guidelines to facilitate the optimal therapy choice for the treatment of neonatal fungal disease do not exist. The current antifungal agents that are available to treat fungemia among newborns and children are based on clinical trials in adults, since there are few comparative studies of antifungal agents in infants. The most commonly used drugs for the treatment of invasive fungal infections in neonates are classified in four different classes: polyene, azoles, analogs of pyrimidines and echinocandins.

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Risk factors of late-onset neonatal sepsis in Taiwan: A matched case-control study

Abstract: Parenteral nutrition was a significant and independent risk of late-onset neonatal sepsis. This risk should be considered when implementing early parenteral nutrition in NICUs.

Cited by 30 publications

References 20 publications

Changing of bloodstream infections in a medical center neonatal intensive care unit

Changing of bloodstream infections in a medical center neonatal intensive care unit

Early and Late Infections in Newborns: Where Do We Stand? A Review

Fungal Infections in Neonatal Intensive Care

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