Risk Factors of Keloids: A Mini Review

Shaheen, Abeer

doi:10.26420/austinjdermatolog.2017.1074

Cited by 3 publications

(4 citation statements)

References 19 publications

(79 reference statements)

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“…The same was found by Udo-Affah, who found the highest frequency in people who are 22-29 years old [18]. However, an increase in elastic skin conditions and high hormonal activity can also affect this condition (5). Based on UV exposure, it was discovered that with active and productive such that most of their activities are conducted outside, thus the risk of getting UV exposure was high, and consequently increasing keloid [19], [20].…”

Section: Discussionmentioning

confidence: 61%

“…Furthermore, the longest period for the disease was found to be 1-3 years, and some others were discovered to have it more than 3 years after the injury. It usually appears from months to years after trauma [5], [22]. Based on location, it is mostly found in the head and around the neck.…”

Section: Discussionmentioning

confidence: 99%

“…The ratio of keloids between dark-and light-skinned people is between 5 and 18.7. Meanwhile, no case has been reported in albinos [3], [5], [6].…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Melanin Content with Collagen Density in Keloid Patients

Wihastyoko

Perdanakusuma

Soeharto

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Keloid is a form of wound healing that results from fibrous tissue activity. It can develop beyond the boundaries of the original wound, extends into the dermis layer, and disrupting the appearance. Previously, no studies have revealed a correlation between melanin pigment and keloid. AIM: This research aimed to describe the correlation between melanin concentration and collagen deposition in keloid tissue. MATERIALS AND METHODS: A prospective study conducted through the application of a cross-sectional analytic survey method. The color of the skin was measured using a chromameter, and a histopathologic examination was performed on the skin surrounding the keloid, as well as the keloid tissue. Data were analyzed using a t-test, correlation, and linear regression statistics. RESULTS: The results showed a significant difference between melanin concentration and collagen deposition in the skin surrounding the keloid tissue. No significant difference was observed between melanin concentration in the surrounding skin of keloid and those in the keloid tissue, as well as collagen deposition. Meanwhile, the melanin concentration in the surrounding skin of keloid and keloid tissue had a significant relationship with fibrocytes number. CONCLUSION: There is a significant correlation between melanin concentrations and collagen density in the keloid tissue.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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Correlation of Melanin Content with Collagen Density in Keloid Patients

Wihastyoko

Perdanakusuma

Soeharto

et al. 2021

Open Access Maced J Med Sci

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“…2 Keloids are more common in people aged 20-30 and those with high hormone levels, such as during puberty and pregnancy. 3 Besides causing appearance disturbances, keloids are accompanied by complaints of itching and pain. 4 Existing keloid treatments have painful procedures, are expensive, are only used on keloids of small size, and require repeated procedures.…”

Section: Introductionmentioning

confidence: 99%

Effects of Green Tea Leaf Extract on Viability, Apoptosis, and Expression of Interleukin-6 in Keloid Fibroblasts

Fasihah,

Hadi,

Mustofa

2023

MMJKK

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Green tea leaf (Camellia sinensis) extract contains polyphenols, anti-inflammatory and anti-carcinogenic agents that may effectively to as keloid therapy. This study aims to examine the effect of green tea leaf extract on viability, apoptosis, and interleukin-6 expression in keloid fibroblasts. Keloid fibroblast cultures were divided into groups that were cultivated with green tea extract at dosages of 100, 200, 400, and 800 μg/mL, negative control (10% Fetal Bovine Serum/FBS), and positive control (100 μM dexamethasone). This study used post-test-only control group design. The highest mean IL-6 expression was in the GTE 200 (275,942.7 pg/mL), while the lowest was in the GTE 800 ( -2,890.6 pg/mL). The viability and apoptosis was analized by using one-way ANOVA, continued with Least Significant Difference (LSD) with a significance of p 0.05 in the GTE 800 treatment group compared to the entire intervention group. Kruskal-Wallis followed by a Mann-Whitney was carried out for interleukin-6 (IL-6) with a significance of p 0.05 in the extract therapy group at dosages of 200, 400, 800 μg/ml and 100 μM dexamethasone. In conclusion, green tea leaf extract at 800 μg/ml could reduce viability interleukin-6 expression and increase apoptotic caspase-3 expression in keloid fibroblast cells.

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