Risk factors of erosive esophagitis and barrett’s esophagus in patients with reflux symptoms

Asreah, Rabah; Abdullhameed, Ali

doi:10.47176/mjiri.35.75

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…They were published between 1985 and 2022. Sixteen studies were performed in Asia, 19 – 34 16 in Europe, 35 – 50 14 in America, 51 – 64 and 1 in Oceania. 65 …”

Section: Resultsmentioning

confidence: 99%

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Ma,

Tong,

et al. 2024

Therap Adv Gastroenterol

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Background: Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma. It is critical to recognize the risk factors associated with BE. Objectives: The present meta-analysis aims to systematically estimate the association of hiatal hernia with the risk of BE. Design: A meta-analysis with trial sequential analysis. Data sources and methods: The PubMed, EMBASE, and Cochrane Library databases were searched. The pooled odds ratios (ORs) and adjusted ORs (aORs) with their 95% confidence intervals (CIs) were calculated for the combined estimation of unadjusted data and data adjusted for confounders, respectively. Heterogeneity was quantified using the Cochrane Q test and I² statistics. Subgroup, meta-regression, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity. Results: Forty-seven studies with 131,517 participants were included. Based on the unadjusted data from 47 studies, hiatal hernia was significantly associated with an increased risk of any length BE (OR = 3.91, 95% CI = 3.31–4.62, p < 0.001). The heterogeneity was significant ( I² = 77%; p < 0.001) and the definition of controls ( p = 0.014) might be a potential contributor to heterogeneity. Based on the adjusted data from 14 studies, this positive association remained (aOR = 3.26, 95% CI = 2.44–4.35, p < 0.001). The heterogeneity was also significant ( I² = 65%; p < 0.001). Meta-analysis of seven studies demonstrated that hiatal hernia was significantly associated with an increased risk of long-segment BE (LSBE) (OR = 10.01, 95% CI = 4.16–24.06, p < 0.001). The heterogeneity was significant ( I² = 78%; p < 0.001). Meta-analysis of seven studies also demonstrated that hiatal hernia was significantly associated with an increased risk of short-segment BE (OR = 2.76, 95% CI = 2.05–3.71, p < 0.001). The heterogeneity was not significant ( I² = 30%; p = 0.201). Conclusion: Hiatal hernia should be a significant risk factor for BE, especially LSBE. Registration: PROSPERO registration number CRD42022367376.

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“…They were published between 1985 and 2022. Sixteen studies were performed in Asia, 19 – 34 16 in Europe, 35 – 50 14 in America, 51 – 64 and 1 in Oceania. 65 …”

Section: Resultsmentioning

confidence: 99%

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Ma,

Tong,

et al. 2024

Therap Adv Gastroenterol

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“…This is a concern since between 2003 and 2006, in the USA, there were approximately 10,570 hospital admissions annually due to erosive esophagitis [ 3 , 33 ]. Barrett’s esophagus is also a complication with GERD following on from NERD and dysphagia, with some studies suggesting erosive esophagitis as a major risk factor for Barrett’s esophagus, with up to a fivefold increased risk [ 9 , 34 , 35 ]. The risk of Barrett’s esophagus increases with the length of time of untreated GERD [ 36 ] and is typically a precursor to esophageal adenocarcinoma [ 3 , 35 , 37 ].…”

Section: Reviewmentioning

confidence: 99%

“…Serious complications include dysphagia and Barrett's esophagus, potentially leading to esophageal adenocarcinoma [3]. GERD is a common condition, often due to abnormalities in the lower esophageal sphincter [4,5], with a pooled global prevalence of 13.3% or more of the population reporting at least weekly symptoms with rates increasing; however, with appreciable geographical variation [1,3,[6][7][8][9][10]. Weekly prevalence rates currently range from 2.5% of the population in China up to 51.2% in Greece [6].…”

Section: Introductionmentioning

confidence: 99%

Key Considerations From a Health Authority Perspective When Proton Pump Inhibitors Are Used to Treat Gastroesophageal Reflux Disease (GERD) and Their Implications

Meyer¹,

MacBride-Stewart²,

Fadare³

et al. 2022

Cureus

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The growing prevalence of gastroesophageal reflux disease (GERD) needs to be carefully managed to relieve the symptoms and prevent complications. Complications of GERD can include erosive esophagitis, Barrett’s esophagus and gastrointestinal (GI) bleeding. Proton pump inhibitors (PPIs) are typically first-line treatment for GERD alongside lifestyle changes in view of their effectiveness and cost-effectiveness. However, there are concerns with adherence to dosing regimens and recommended lifestyle changes reducing their effectiveness. There are also concerns about potential complications from chronic high-dose PPIs. These include an increased risk of chronic kidney disease, cardiovascular events and infections. Recommendations to physicians include prescribing or dispensing the lowest dose of PPI for the shortest time, with ongoing patient monitoring. Activities among community pharmacists and others have resulted in increased dispensing of PPIs without a prescription, which can be a challenge. PPIs are among the most prescribed and dispensed medicines in view of their effectiveness in managing GERD. However, there are concerns with the doses prescribed and dispensed as well as adherence to lifestyle advice. These issues and challenges need to be addressed by health authorities to maximize the role and value of PPIs.

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Risk factors for Barrett’s esophagus: Recent advances

Ma¹,

Chen²,

Zhen-dong³

et al. 2022

WCJD

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Risk factors of erosive esophagitis and barrett’s esophagus in patients with reflux symptoms

Abstract: Background (BE) are the tw symptoms who Methods: We the patients in classified accor and the two-sa endoscopic dat Results: For (p=0.001) and (p=0.004) was Conclusion: older age. For B

Cited by 4 publications

References 28 publications

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Key Considerations From a Health Authority Perspective When Proton Pump Inhibitors Are Used to Treat Gastroesophageal Reflux Disease (GERD) and Their Implications

Risk factors for Barrett’s esophagus: Recent advances

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