Risk Factors for Visual Field Progression in the Low-pressure Glaucoma Treatment Study

Association of blood and ocular perfusion pressure with structural glaucomatous progression by flicker chronoscopy

“…Lower MOPP has been consistently associated with prevalence including its association in the Baltimore Eye Survey and Barbados Eye Study 1 7. In addition, the Low-pressure Glaucoma Treatment Study (LoGTS) found decreased MOPP to be associated with increased risk of functional progression by visual field analysis 20. While MOPP was not associated with global progression in our study, it was associated with structural progression by RNFL loss and PPA.…”

Relationship Between Daytime Variability of Blood Pressure or Ocular Perfusion Pressure and Glaucomatous Visual Field Progression

“…38,41 However, older age was not a significant predictor of the VF progression in the present study. Detection of an effect of age on the VF progression rate may have been difficult due to the relatively short period of follow-up (mean, 3.2 years).…”

Update on the Prevalence, Etiology, Diagnosis, and Monitoring of Normal-Tension Glaucoma

“…Patients with NTG having systemic vascular risk factors, including autonomic dysfunction with sympathetic predominance (lower heart rate variability) 116 or low nocturnal blood pressure, especially pressure that is 10 mm Hg lower than daytime mean arterial pressure, 59 are reported to be at greater risk of progressive visual field loss. Lower mean ocular perfusion pressure increased the risk of progression in a low-pressure glaucoma treatment study, 117 and unstable ocular perfusion pressure with large fluctuation was the most consistent prognostic factor for central visual field progression in an investigation by Sung et al 118 However, care should be exercised when interpreting ocular perfusion pressure: as blood pressure and IOP are its main determinants, their statuses should not be overlooked.…”

“…115 In such patients, IOP-independent risk factors, such as autonomic dysfunction, 116 low nocturnal blood pressure, 59 low ocular perfusion pressure, 117 and large fluctuation of ocular perfusion pressure, 118 can play more dominant roles in the disease course. Patients with NTG having systemic vascular risk factors, including autonomic dysfunction with sympathetic predominance (lower heart rate variability) 116 or low nocturnal blood pressure, especially pressure that is 10 mm Hg lower than daytime mean arterial pressure, 59 are reported to be at greater risk of progressive visual field loss.…”