Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study

Wang, Yang; Du, Ming-Fei; Gao, Weihua; Fu, Bowen; Yu, Yan; Yuan, Yue; Chu, Chao; Chen, Chen; Liao, Yue‐Yuan; Gao, Ke; Wang, Keke; Li, Min; Sun, Yue; Hu, Jiawen; Chen, Xin; Ma, Qiang; Wang, Dan; Zhang, Xiao-Yu; Li, Chunhua; Zhou, Hao-Wei; Lu, Wei; Yuan, Zuyi; Chang, John; Mu, Jianjun

doi:10.1038/s41430-020-00752-x

Cited by 14 publications

(23 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood pressure (BP) was measured by three trained staff members using a standard mercury sphygmomanometer as described previously. 20 , 21 , 24 , 25 BP staff were blinded to the study design. The subjects were instructed to refrain from drinking alcohol, coffee or tea, smoking cigarettes, and exercising for at least 30 min prior to their BP measurement.…”

Section: Methodsmentioning

confidence: 99%

Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study

Wang

Chu

et al. 2022

eClinicalMedicine

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study

Wang

Chu

et al. 2022

eClinicalMedicine

Self Cite

View full text Add to dashboard Cite

“…In 1987, we established the cohort of Hanzhong Adolescent Hypertension Study, which was an ongoing prospective, population-based cohort study of 4,623 adolescents aimed to screen for cardiovascular risk factors that originate in childhood and adolescence. Detailed information of study has been published elsewhere (25)(26)(27)(28)(29)(30). To explore the association of serum uromodulin levels with the risk of hypertension, we used cross-sectional analysis of the latest follow-up data in 2017.…”

Section: Protocol 2: a Cross-sectional Cohort Study To Examine The Relationships Between Serum Uromodulin Levels And The Incidence Of Hypmentioning

confidence: 99%

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.

show abstract

“…However, considering that statistical significance disappeared after excluding individuals taking medication for dyslipidemia, categorizing individuals taking medication for dyslipidemia (e.g., statins) in the nonideal cholesterol status group might have influenced the result. There are no consistent data on the relationship between total cholesterol and the development of proteinuria [20, 27, 28], and further research and discussion is needed.…”

Section: Discussionmentioning

confidence: 99%

Change in Cardiovascular Health Metrics and Risk for Proteinuria Development: Analysis of a Nationwide Population-Based Database

et al. 2022

View full text Add to dashboard Cite

Introduction: Evidence is lacking regarding the association between cardiovascular health (CVH) metrics and the risk for proteinuria. Methods: We performed this observational cohort study including 865,087 participants (median age, 46 years, 60.7% men) with negative proteinuria at the initial health check-up, who underwent repeated health check-ups within 4 years. Ideal CVH metrics included nonsmoking, body mass index <25 kg/m2, physical activity at goal, eating breakfast, blood pressure <120/80 mm Hg, fasting plasma glucose <100 mg/dL, and total cholesterol <200 mg/dL. The primary outcome was incident proteinuria, defined as ≥1 + on the urine dipstick test. Results: Participants were categorized as having low CVH metrics defined as having 0–2 ideal CVH metrics (n = 84,439), middle CVH metrics defined as having 3–4 ideal CVH metrics (n = 335,773), and high CVH metrics defined as having 5–7 ideal CVH metrics (n = 444,875). Compared with low CVH metrics, middle CVH metrics (odds ratio (OR): 0.61, 95% CI: 0.59–0.63) and high CVH metrics (OR: 0.45, 95% CI: 0.43–0.46) were associated with a lower risk of proteinuria. The OR of a one-point increase in the ideal number of CVH metrics was 0.83 (95% CI: 0.82–0.83). All CVH metrics components except for ideal total cholesterol were associated with a decreased risk of proteinuria. A one-point improvement in the number of ideal CVH metrics at 1 year after the initial health check-up was associated with a decreased incidence of proteinuria (OR: 0.90, 95% CI: 0.89–0.92). Conclusion: Not only maintaining better CVH metrics but also improving CVH metrics would prevent developing proteinuria in a general population.

show abstract

Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study

Cited by 14 publications

References 42 publications

Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study

Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Change in Cardiovascular Health Metrics and Risk for Proteinuria Development: Analysis of a Nationwide Population-Based Database

Contact Info

Product

Resources

About