Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study

Schuster, Heleen J.; Peelen, Myrthe; Hajenius, Petra J.; Beukering, Monique van; Eekelen, Rik van; Schonewille, Marit; Playfair, Henna; Post, Joris A. M. van der; Kok, Marjolein; Painter, Rebecca C.

doi:10.1002/hsr2.585

Cited by 4 publications

(2 citation statements)

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“…For this study, we used data and vaginal swab material from women included in the PROPELLOR cohort. The study protocol and methods are described in a previous publication [ 29 ]. In short, the study included nulliparous women ≥ 18 years who received antenatal care at participating midwifery practices in the Netherlands before 24 weeks of gestation and had a low-risk singleton pregnancy at their first visit.…”

Section: Methodsmentioning

confidence: 99%

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The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth

Schuster,

Breedveld,

Matamoros

et al. 2024

Microbiome

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Background Vaginal microbiota composition is associated with spontaneous preterm birth (sPTB), depending on ethnicity. Host-microbiota interactions are thought to play an important underlying role in this association between ethnicity, vaginal microbiota and sPTB. Methods In a prospective cohort of nulliparous pregnant women, we assessed vaginal microbiota composition, vaginal immunoglobulins (Igs), and local inflammatory markers. We performed a nested case–control study with 19 sPTB cases, matched based on ethnicity and midwifery practice to 19 term controls. Results Of the 294 included participants, 23 pregnancies ended in sPTB. We demonstrated that Lactobacillus iners-dominated microbiota, diverse microbiota, and ethnicity were all independently associated with sPTB. Microbial Ig coating was associated with both microbiota composition and ethnicity, but a direct association with sPTB was lacking. Microbial IgA and IgG coating were lowest in diverse microbiota, especially in women of any ethnic minority. When correcting for microbiota composition, increased microbial Ig coating correlated with increased inflammation. Conclusion In these nulliparous pregnant women, vaginal microbiota composition is strongly associated with sPTB. Our results support that vaginal mucosal Igs might play a pivotal role in microbiota composition, microbiota-related inflammation, and vaginal community disparity within and between ethnicities. This study provides insight in host-microbe interaction, suggesting that vaginal mucosal Igs play an immunomodulatory role similar to that in the intestinal tract.

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Section: Methodsmentioning

confidence: 99%

“…The data that support the findings of this study, including the raw sequencing data, are available from the corresponding author on reasonable request. Extensive data and material availability is described in a previous publication [ 29 ].…”

mentioning

confidence: 99%

The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth

Schuster,

Breedveld,

Matamoros

et al. 2024

Microbiome

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Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study

Schuster

Peelen

Hajenius

et al. 2022

Health Science Reports

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Working conditions in low risk nulliparous women in The Netherlands: are legislation and guidelines a guarantee for a healthy working environment? A cohort study

Beukering

Schuster

Peelen

et al. 2022

Int Arch Occup Environ Health

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Objective Hazardous working conditions increase the risk of adverse pregnancy outcomes. In this study, we examine adherence to legislation and guidelines aimed at improving working conditions in pregnancy. Methods Between 2014 and 2016, we recruited a prospective cohort of low-risk nulliparous pregnant women in paid employment or self-employed in 16 community midwifery practices in The Netherlands. Participants completed two questionnaires concerning demographics, education, general health and working conditions between 10–16 and 20–24 weeks of pregnancy. We calculated the proportion of participants with work-related risk factors not in accordance with legislation and/or guidelines. Results Of 269 participants included, 214 (80%) completed both questionnaires. At 10–16 weeks 110 (41%) participants and at 20–24 weeks 129 (63%) participants continued to work under circumstances that did not meet recommendations. Employers provided mandated information on work adjustment to 37 (15%) participants and 96 (38%) participants received no information about the potential hazards while working with biological and chemical hazards. Participants with lower educational attainment (aOR 2.2 95%CI 1.3–3.9), or employment in healthcare (aOR 4.5, 95%CI 2.2–9.0), education/childcare and social service (aOR 2.6, 95%CI 1.1–6.0 2),, catering (aOR 3.6, 95%CI 1.1–12) and industry, construction and cleaning (aOR 3.3, 95%CI 1.1–10.3) more often continued work which did not meet recommendations. Conclusion There is poor adherence to national legislation and guidelines for safe working in pregnancy in The Netherlands: 50% of the pregnant women worked under hazardous conditions. Given the impact on adverse pregnancy outcomes as well as on the public purse, action to improve compliance must be taken by all stakeholders.

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Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study

Cited by 4 publications

References 36 publications

The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth

The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth

Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study

Working conditions in low risk nulliparous women in The Netherlands: are legislation and guidelines a guarantee for a healthy working environment? A cohort study

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