Risk Factors for Recurrent Colorectal Polyps

et al. 2020

Lipids Health Dis

Background Recurrence of colorectal polyps is common and impacted by various factors. This study was performed to explore the association between lipid profiles and recurrence of colorectal polyps. Methods This study retrospectively analyzed the lipid profiles of 435 patients who underwent colonoscopy with removal of colorectal polyps and assessed recurrence of polyps by follow-up colonoscopy. Multivariate regression logistic analysis was used to evaluate the association between lipid profiles and polyp recurrence. Results During the 1.5-year follow-up, recurrence of colorectal polyps was observed in 135 of 435 patients (30.34%). Patients with recurrent polyps showed a higher level of triglycerides (P = 0.006) and lower levels of high-density lipoprotein cholesterol (P = 0.008) and apolipoprotein A1 (P = 0.033). The multivariate regression logistic model suggested that an elevated triglyceride level was an independent risk factor for polyp recurrence (odds ratio, 1.55; 95% confidence interval, 1.02–2.35; P = 0.039) in patients with advanced adenoma. Conclusions Lipid profiles are associated with recurrence of colorectal polyps. An elevated triglyceride level is an independent risk predictor of polyp recurrence in patients with advanced adenoma.

Section: Discussionmentioning

confidence: 98%

“…The occurrence rates of different types of polyps widely range from 1 to 43% [6]. Specific factors have been reported to contribute to polyp recurrence, such as age, sex, lifestyle, and polyp characteristics [9]. Obesity and the body mass index (BMI) have long been studied as risk factors for polyp recurrence [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Elevated serum triglyceride predicts recurrence of colorectal polyps in patients with advanced adenomas

et al. 2020

Lipids Health Dis

“…A series of factors have been reported to associate with polyp recurrence, e.g. age, gender, lifestype, genetic background, characteristics of polyps, procedural factors [8,[20][21][22][23]. This study compared the baseline clinical characteristics of patients, as well as of colorectal polyps.…”

Section: Discussionmentioning

confidence: 99%

“…Identi cation of risk factors that are predictable for recurrence of colorectal polyps is crucial for protecting at-risk individuals against CRC. Various factors are reported to impact the recurrence rate of polyps, such as gender, age, lifestyle, histology features [8]. Leo et al reported that metabolic factors accelerated colorectal adenoma recurrence [9].…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Triglyceride Predicates Recurrence of Colorectal Polyps in Patients with Advanced Adenomas

et al. 2020

Preprint

Background The recurrence of colorectal polyps is common and impacted by various factors. The aim of this study is to explore the association between lipid profiles and recurrence of colorectal polyps. Methods We retrospectively analyzed lipid profiles of 435 patients underwent colonoscopy with removal of colorectal polyps, and observed the recurrence of polyps by follow-up endoscopy within the following 1.5 years. Regression logistic was used to evaluate the association between lipid profiles and polyp recurrence. Results During the 1.5-year follow-up, recurrences of colorectal polyps were observed in 135 out of 435 patients (30.34%). Patients with recurrent polyps showed higher levels of total cholesterol (TG) (P = 0.006), lower levels of high-density lipoprotein cholesterol (HDL-C) (P = 0.008) and apoliprotein A1 (ApoA1) (P = 0.033). Regression logistic model suggested that TG was an independent risk factor of polyp recurrence (OR: 1.81; CI: 1.29–2.55; P = 0.039) in patients with advanced adenomas. Conclusions The lipid profiles are associated with the recurrence of colorectal polyps. Elevated TG would serve as an independent risk predictor of polyp recurrence in patients with advanced adenomas.

“…The occurrence rates of different types of polyps widely range from 1% to 43% [6]. Speci c factors have been reported to contribute to polyp recurrence, such as age, sex, lifestyle, and polyp characteristics [9]. Obesity and the body mass index (BMI) have long been studied as risk factors for polyp recurrence [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Elevated serum triglyceride predicates recurrence of colorectal polyps in patients with advanced adenomas

et al. 2020

Preprint

Background: Recurrence of colorectal polyps is common and impacted by various factors. This study was performed to explore the association between lipid profiles and recurrence of colorectal polyps. Methods: This study retrospectively analyzed the lipid profiles of 435 patients who underwent colonoscopy with removal of colorectal polyps and assessed recurrence of polyps by follow-up colonoscopy. Multivariate regression logistic analysis was used to evaluate the association between lipid profiles and polyp recurrence. Results: During the 1.5-year follow-up, recurrence of colorectal polyps was observed in 135 of 435 patients (30.34%). Patients with recurrent polyps showed a higher level of triglycerides ( P = 0.006) and lower levels of high-density lipoprotein cholesterol ( P = 0.008) and apolipoprotein A1 ( P = 0.033). The multivariate regression logistic model suggested that an elevated triglyceride level was an independent risk factor for polyp recurrence (odds ratio, 1.55; 95% confidence interval, 1.02 - 2.35; P = 0.039) in patients with advanced adenoma. Conclusions: Lipid profiles are associated with recurrence of colorectal polyps. An elevated triglyceride level is an independent risk predictor of polyp recurrence in patients with advanced adenoma. Keywords: Colorectal polyp, Recurrence, Lipid profile, Triglyceride, Risk factor.