Elevated Serum Triglyceride Predicates Recurrence of Colorectal Polyps in Patients with Advanced Adenomas

Abstract

Background The recurrence of colorectal polyps is common and impacted by various factors. The aim of this study is to explore the association between lipid profiles and recurrence of colorectal polyps. Methods We retrospectively analyzed lipid profiles of 435 patients underwent colonoscopy with removal of colorectal polyps, and observed the recurrence of polyps by follow-up endoscopy within the following 1.5 years. Regression logistic was used to evaluate the association between lipid profiles and polyp recurrence. Results During the 1.5-year follow-up, recurrences of colorectal polyps were observed in 135 out of 435 patients (30.34%). Patients with recurrent polyps showed higher levels of total cholesterol (TG) (P = 0.006), lower levels of high-density lipoprotein cholesterol (HDL-C) (P = 0.008) and apoliprotein A1 (ApoA1) (P = 0.033). Regression logistic model suggested that TG was an independent risk factor of polyp recurrence (OR: 1.81; CI: 1.29–2.55; P = 0.039) in patients with advanced adenomas. Conclusions The lipid profiles are associated with the recurrence of colorectal polyps. Elevated TG would serve as an independent risk predictor of polyp recurrence in patients with advanced adenomas.