Risk Factors for Recurrences of Central Serous Chorioretinopathy

Matet, Alexandre; Daruich, Alejandra; Zola, Marta; Behar‐Cohen, Francine

doi:10.1097/iae.0000000000001729

Cited by 67 publications

(65 citation statements)

References 62 publications

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“…CNV in the setting of chronic CSCR is relatively infrequent. [22][23][24] With the advent of OCTA, an increased incidence of CNV has been reported in chronic CSCR. 4 9 25 In the present study, we found that 7.23% of CSCR patients had CNV.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography of flat irregular pigment epithelial detachments in central serous chorioretinopathy

et al. 2020

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BackgroundTo identify and analyse the character and relationship between flat irregular pigment epithelial detachment feature (FIPED), choroidal thickness and choroidal neovascularisation (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with central serous chorioretinopathy (CSCR) in Chinese patients.MethodIn the present study, 152 eyes of 144 Chinese patients, who were previously diagnosed with CSCR, were retrospectively studied. Patients’ baseline characteristics, the course of CSCR, best-corrected visual acuity, the pattern of CNV on OCTA, FIPED and choroidal thickness detected by enhanced depth imaging-OCT (EDI-OCT) were analysed.ResultsIt was disclosed that 7.23% of CSCR patients had CNV. Age and the course of CSCR were found to be correlated with the occurrence of CNV. Among the eyes with CNV network (11 eyes), 100% of them had FIPED, whereas, among the eyes without CNV (141 eyes), 18.04% had FIPED. The maximum width and en-face area of PED were greater in the CNV group compared with that in the non-CNV group (p<0.001). It also was revealed that female gender and a poor vision were risk factors for CNV in eyes with CSCR. The choroidal thickness detected by EDI-OCT was also statistically significant between eyes with CNV and eyes without CNV. The patients who have CNV complicated with FIPED are susceptible to have low vision.ConclusionThe present research demonstrated that the majority of CNV cases were linked to FIPED, and the thinner thickness of choroid. The greater width and en-face area of PED may point towards the presence of an underlying CNV network.

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Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography of flat irregular pigment epithelial detachments in central serous chorioretinopathy

et al. 2020

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“…25 Nevertheless, their presence and number have been associated with the recurrence of the disease and its visual outcome. 26,27 In diabetic retinopathy, HRF could be a sign of lipid and/or protein extravasation 28 or may represent activated microglial cells. 29 In both cases their quantification may be useful to monitor the progression of the retinopathy and its response to treatmanent.…”

Section: Discussionmentioning

confidence: 99%

Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression

Nassisi

Fan

Shi

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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METHODS. Volume optical coherence tomography (OCT) scans from 114 eyes of 114 patients were retrospectively reviewed. HRF were assessed both qualitatively and quantitatively. Five sequential en face slabs from midretina were thresholded to isolate the HRF. These five slabs were recombined, and HRF area was measured in the whole 6 3 6-mm image (HRF TOT ) and within the central 3-mm (HRF 3mm ) and 5-mm (HRF 5mm ) regions. These measurements were correlated with the development of late AMD (defined as choroidal neovascularization [CNV] and/or complete RPE and photoreceptor atrophy [cRORA]) after 1 year of follow-up.RESULTS. HRF area in all three regions showed significant correlations with progression to late AMD: R ¼ 0.610 for HRF 3mm , R ¼ 0.622 for HRF 5mm , and R ¼ 0.614 for HRF TOT (all P < 0.001). Correlations remained significant with progression to cRORA alone, though not for progression to CNV alone. While qualitative assessment of HRF (i.e., presence of HRF: yes or no) also showed a significant correlation with progression to late AMD (R ¼ 0.454, P < 0.001) and atrophy alone (R ¼ 0.445, P < 0.001), they were weaker than by HRF quantification.CONCLUSIONS. The area of HRF from en face OCT in eyes with intermediate AMD correlates with the 1-year risk of progression to late AMD, and in particular with the development of atrophy.

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“…Recently, an abnormal increase in CT has been hypothesized to contribute to CSC [17], primary open angle glaucoma (POAG) [18], and primary angle closure glaucoma (PACG) [13]. Given its anatomical location, scleral inflammation can spread to the choroid, so CT was supposed to be affected due to inflammation in PS.…”

Section: Discussionmentioning

confidence: 99%

The clinical features of posterior scleritis with serous retinal detachment: A retrospective clinical analysis

Dong

Gan

Zhang

et al. 2018

Preprint

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Objective: To summarize the clinical features, systemic associations, risk factors and choroidal thickness(CT) changing in posterior scleritis (PS) with serous retinal detachment. Methods: This retrospective study included 23 patients with PS with retinal detachment from August 2012 to July 2017. All patients were documented with the Medical history and clinical features were recorded. The examinations included best corrected visual acuity (BACV), intraocular pressure（IOP）, fundus examination, routine eye examinations. Posterior coats thickness (PCT) was determined by B scan Ultrasound, the CT was measured by enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). And clinical data were compiled and analyzed. Results: After application of extensive exclusion criteria, 23 patients with PS remained (13 females, 10 males). The average age at presentation was 29.5 ± 9.24 years old. Ocular pain and blurred vision were the two most common symptoms complained by patients. Anterior scleritis occurred in 12 patients, which was confirmed by Ultrasound Biomicroscopy (UBM) examination. Despite all patients displaying serous retinal detachment in their macula, no fluorescein leakage was observed in the macular. Optic disc swelling was documented in 10 of the 23 eyes. From B-scan ultrasound examination, the PCT increased with fluid in Tenon’s capsule demonstrated as a typical T-sign. The average PCT was 2.51 ± 0.85 mm in the PS-affected eye and only 1.09 ± 0.29 mm in the unaffected eye; this difference reached statistical significance. The subfoveal CT increased to an average of 442.61 ± 55.61μm, which correlated with axis length and PCT, but not with IOP. The BCVA and IOP did not correlate with either CT or the PCT. Conclusions: PS with serous retinal detachment presented with a variety of symptoms, such as pain and visual loss, and physical indicators. Typical T-sign detected by B-scan ultrasound was a useful confirmatory sign for PS diagnosis. Pathological increases in CT might be a potential predictive factor for inflammation.

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Risk Factors for Recurrences of Central Serous Chorioretinopathy

Abstract: Multiple factors influence the risk of central serous chorioretinopathy recurrence. These findings may contribute to identify patients at higher risk, who could benefit from earlier or more intensive treatment.

Cited by 67 publications

References 62 publications

Optical coherence tomography angiography of flat irregular pigment epithelial detachments in central serous chorioretinopathy

Optical coherence tomography angiography of flat irregular pigment epithelial detachments in central serous chorioretinopathy

Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression

The clinical features of posterior scleritis with serous retinal detachment: A retrospective clinical analysis

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