Risk factors for recurrence in patients with stage IB, IIA, and IIB cervical carcinoma after radical hysterectomy and postoperative pelvic irradiation

Abstract

This retrospective study suggests that stage IB, IIA, and IIB cervical carcinoma cases with the above-mentioned pathologic factors are at higher risk of recurrence after abdominal radical hysterectomy with pelvic lymph node dissection and postoperative pelvic irradiation.

Differing prognosis of cervical cancer patients with high risk of treatment failure after radical hysterectomy warrants trial treatment modification

“…8,14,15 Also, other nodal characteristics, such as laterality of positive nodes, common iliac node involvement, and paraaortic lymph node metastasis, were found to be independent prognostic factors in several reports. 11,16 With regard to results of adjuvant CCRT, an intergroup trial involving the Gynecologic Oncologic Group, the Southwestern Oncology Group, and the Radiation Therapy Oncology Group reported that postoperative concurrent chemradiation had 4-year disease free survival (DFS) of 81%. 17 In this study, DFS of the total 58 patients was 78.3%, which corresponds to the interGroup result.…”

Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

“…Most have relative short median followup time of five years and less and give information on relapsefree interval and survival rate in stage 1b in variable ways. The survival depends on a number of factors like tumor size, invasion depth, lymph vessel involvement, histology, and metastasis [1,4]. The lymph node involvement is still the single most common and, thus, important find.…”

“…The concurrent increasing incidence of adenocarcinoma associated with use of oral contraceptives in the Western World is a concern to that it may reverse the positive effect of screening [6,7]. However, the survival relates heavily on different pre-and postoperative treatment regimens and stage of disease [1,3,4]. Adverse histopathological factors are often present simultaneously and reviewed heterogeneously.…”

“…Other factors like tumor size and depth of stromal invasion indicate aggressive biological behavior. Poorer survival depending on histological type of tumor is reported in adenocarcinoma compared to squamous carcinoma [1][2][3][4][5][6][7]. The concurrent increasing incidence of adenocarcinoma associated with use of oral contraceptives in the Western World is a concern to that it may reverse the positive effect of screening [6,7].…”

Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism

“…3 An ideal cancer treatment should be able to eradicate systemic tumors at multiple sites in the body and should have the ability to discriminate between neoplastic and non-neoplastic cells. The present available forms of treatment for cervical cancer, for example surgery, radiation therapy and chemotherapy, 7,8 are all cytoreductive treatment modalities. This means that in addition to cancerous cells, healthy cells are also destroyed in the process.…”