Differing prognosis of cervical cancer patients with high risk of treatment failure after radical hysterectomy warrants trial treatment modification

Abstract

Objective: The aim of this study was to ascertain whether all cervical cancer patients who received adjuvant concurrent chemoradiation (CCRT) for high risk of treatment failure after radical hysterectomy are at the same risk of treatment failure, and if not, to propose trial treatment modification. Methods: Between January 1999 and December 2007, 58 patients with FIGO stage Ib-IIa cervical cancer received adjuvant CCRT due to high risk factors such as positive lymph nodes or positive parametrium, or positive vaginal resection margins. Patients were divided into two Groups. Group A were patients with negative parametrium, negative vaginal resection margins, and only unilateral lymph node metastasis (involved L/N≤2). Group B were those with either bilateral pelvic lymph node involvement, or more than 2 lymph node involvement, or positive parametrium with lymph node involvement. Results: During a median follow-up period of 34 months (range, 6 to 102 months), 9 patients (15.5%) experienced recurrence; among whom 2 patients (2/28, 7.1%) were Group A, and 7 patients (7/30, 23.3%) were Group B. At 3 years, the estimated progression-free survival rate of all 58 patients was 78.3%, and the overall survival rate was 89.7%. Patients in Group A had significantly better progression-free survival (88.2% vs. 68.2%, p=0.042) and overall survival rate (100% vs. 78.8%, p=0.034) than Group B. Conclusion: Treatment modifications such as consolidation chemotherapy after CCRT may be considered based on the poor prognosis of very high risk patients such as those patients in Group B.

Prognostic factors affecting survival and recurrence in patients with early cervical squamous cell cancer following radical hysterectomy

“…2 Radical surgery is the standard treatment for early cervical cancer, followed by adjuvant radiotherapy (RT) to improve local control in patients with pathologic risk factors; however, 10% to 20% of patients still have a poor prognosis. 3 – 5 According to National Comprehensive Cancer Network (NCCN) guidelines, several factors have been recognized as high-risk factors, including lymph node (LN) metastasis, parametrial invasion, and positive vaginal margins. In patients without postoperative high-risk factors, tumor size (any, ≥2 cm, ≥4 cm, ≥5 cm), lymphovascular space invasion (LVSI) (positive or negative), and deep stromal invasion (DSI) (deep, middle, and superficial thirds, respectively) are considered as medium-risk factors according to Sedlis standards.…”

Prognostic Value of Log Odds of Positive Lymph Nodes after Radical Surgery Followed by Adjuvant Treatment in High-Risk Cervical Cancer

“…Introduction of adjuvant treatment has led to improved treatment outcomes in cervical cancer; however, 10%-20% of patients still experience treatment failure after radical surgery followed by recommended adjuvant treatment [ 1 - 3 ]. This recurrent disease has an unfavorable prognosis, with a 5-year survival rate of 35% [ 4 ].…”