Risk factors for recurrence after surgery in non‐metastatic RCC with thrombus: a contemporary multicentre analysis

Abstract

Seven risk factors for recurrence were identified for patients with non-metastatic RCC with thrombus, which can be used to select patients who may benefit from increased surveillance or adjuvant therapy clinical trials.

A proposal of post‐operative nomogram for overall survival in patients with renal cell carcinoma and venous tumor thrombus

“…Presence of distant metastasis was also demonstrated to be an independent prognostic factor in multivariate analysis . Tumor Fuhrman grade and maximum width were also common prognosis predictors in patients with RCC and VTT . In the present study, the two variables were found to be a statistically significant predictor for OS in univariable analysis; however, failed to be significant in multivariable analysis.…”

“…Similarly, Nakayama et al constructed a pre‐operative risk stratification model for patients with RCC and VTT; nevertheless, the sample size was small. Abel et al created a recurrence model for patients had non‐metastatic RCC and tumor thrombus.…”

Surgical treatment of renal cell carcinoma: Can morphological features of inferior vena cava tumor thrombus on computed tomography or magnetic resonance imaging be a prognostic factor?

“…In the present study, ECOG performance status was also influenced by OS and CSS in patients with pN any M any . As known, clinical tumor size also influenced OS and CSS . Furthermore, for non‐metastatic patients, remnant venous thrombus correlated significantly with a poor prognosis.…”

“…Additionally, patients with non-clear cell RCC subtypes influenced OS and CSS compared with clear cell RCC subtype, as observed in previous studies. 7,24,25 In the case of clear cell RCC, the expression of E-cadherin is increased compared with non-clear cell RCC, and such increases are associated with better prognosis, whereas reduced expression of E-cadherin has been associated with poorer prognosis and higher Fuhrman grades. 26 Recent studies on the relationship between prognosis and tumor consistency have classified tumor thrombi into friable or solid according to the level of expression of E-cadherin.…”

Current treatment approach to non-clear cell renal carcinoma

“…[13] отметили отрицательное влияние несветлоклеточного гистологического типа на безрецидивную выживае-мость (ОР 2,98; p = 0,02) и ОВ (ОР 4,03; p = 0,01) па-циентов, перенесших РНЭ с тромбэктомией. В другом ретроспективном многоцентровом анализе с включе-нием 465 больных ПКР с опухолевым тромбом нПКР был среди независимых факторов, влияющих на риск рецидива после операции (ОР 2,13) [14]. Негативное влияние нПКР на исходы хирургического лечения больных с тромбом подтверждает крупный анализ D. Tilki и соавт.…”