Risk Factors for Rectal Cancer and Methylenetetrahydrofolate Reductase Polymorphisms in a Population in Northeast Thailand

Promthet, Supannee; Pientong, Chamsai; Ekalaksananan, Tipaya; Songserm, Nopparat; Poomphakwaen, Kirati; Chopjitt, Peechanika; Wiangnon, Surapon; Tokudome, Shinkan

doi:10.7314/apjcp.2012.13.8.4017

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…In a subsequent study of colon cancer (Promthet et al, 2010), the roles of beef and pork were investigated separately, and neither emerged as a risk factor; alcohol was a risk factor, but only at the lower level of consumption. For rectal cancer (Promthet et al, 2012), pork, but not beef, was a risk factor, and there was no association with alcohol.…”

Section: Introductionmentioning

confidence: 82%

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. This study aimed to investigate the interaction between the presence of a polymorphism of the XRCC1 gene and known risk factors for colorectal cancer in Thailand. Materials and Methods: A hospital-based case-control study was conducted in Thailand. The participants were 230 histologically confirmed new cases and 230 controls matched by sex and age and recruited from the same hospital. Information about demographic characteristics, life style, and dietary habits was collected using structured interviews, and blood samples were taken which were used for the detection of a homozygous and heterozygous polymorphisms of XRCC1. Associations were assessed using multiple conditional logistic regression. Results: In the univariate analysis, factors found to be significantly associated with an increased risk for CRC were the presence of the XRCC1 AA homozygote (OR= 4.95; 95% CI: 1.99-12.3), a first degree family history of cancer (OR= 1.74; 95% CI: 1.18-2.58), and a high frequency of pork consumption (OR= 1.49; 95% CI: 1.00-2.21). Intakes of fish fruit and vegetables appeared to be protective factors, but the associations were not statistically significant. In the multivariate analysis only the XRCC1 AA homozygote polymorphism and a family history of cancer emerged as risk factors (OR= 4.96; 95% CI: 1.90-12.95 and OR=1.80; 95% CI: 1.18-2.72, respectively). Conclusions: While the XRCC1 AA homozygote and a family history of cancer were found to be associated with an increased risk of CRC, none of the dietary intake variables were clearly identified as risk or protective factors. There is a need for further research to determine the reasons for this.

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Section: Introductionmentioning

confidence: 82%

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Poomphakwaen

Promthet²,

Suwanrungruang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Although Helicobacter pylori strains have been proposed to be a major cause of gastric cancer, infections by H. pylori do not account completely for the incidence of gastric cancer. Epidemiological studies have indicated an association between folate intake and a decreased risk of certain cancers (Larsson et al, 2006;Yoo et al, 2012;de Cássia Carvalho et al, 2012;Promthet et al, 2012;Ding et al, 2012), including gastric cancer (Yoo et al, 2012), esophageal cancer (Larsson et al, 2006) and ovarian cancer (Ding et al, 2012). Folate is a key B vitamin required for 1-carbon metabolism and is critical for DNA methylation, synthesis, and repair (Jemal et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site

Chen¹,

Yuan²,

Duan³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of 767 patients with newly diagnosed gastric cancer and 775 controls were selected for this study. Genotyping of MTHFR C677T and A1298C was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System, and information 9719 MTHFR and folate and gastric cancer risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 9718-9726 (2014) on folate intake was collected by questionnaire. Compared with the CC genotype of MTHFR C677T, the TT genotype was significantly associated with a decreased risk of gastric cancer when the analysis was adjusted for other potential risk factors. We found a marginal significantly decreased risk of gastric cancer for individuals carrying the T allele [adjusted odds ratio (OR) = 0.83; 95% confidence interval (CI) = 0.65-1.01]. We detected an inverse relationship between folate intake and risk of gastric cancer, and the adjusted ORs (95%CI) for moderate and high folate intake were 0.97 (0.74-1.25) and 0.64 (0.49-0.87), respectively. Moreover, H. pylori infection, folate intake, and location of the tumor showed a significant interaction with the MTHFR C677T polymorphism. Our study suggests a protective role of MTHFR 677TT and high folate intake against gastric cancer, and the effect of the MTHFR C677T genotype may differ by H. pylori infection, folate consumption, and tumor site.

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“…The study of incidence trend in Thailand for the period 1989–2000 has revealed rapidly increasing rates in all regions, especially in the central region of Thailand that include Bangkok . Increasing red meat and alcohol consumption were reported as possible contributors in several recent Thai studies . In addition to secondary prevention efforts for cervical and breast cancer, the NCCP has established a nationwide screening program for colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…37 Increasing red meat and alcohol consumption were reported as possible contributors in several recent Thai studies. [38][39][40] In addition to secondary prevention efforts for cervical and breast cancer, the NCCP has established a nationwide screening program for colorectal cancer. There is an ongoing health economic evaluation of fecal immunochemical test (FIT) as a tool for organized screening in Thailand; some studies of acceptability and feasibility of the test have already been completed, with results supporting the use of the test.…”

Section: Discussionmentioning

confidence: 99%

Cancer incidence in northern Thailand: Results from six population‐based cancer registries 1993–2012

Pongnikorn

Daoprasert

Waisri

et al. 2017

Intl Journal of Cancer

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Rapid changes in social and economic development have led to cancer becoming a major cause of national morbidity and mortality in Thailand. Cancer registries have been critical in documenting subnational cancer patterns and transitions in the country; with the establishment of six registries in northern Thailand, a comprehensive assessment of the scale and profile of cancer is now possible in the region. Cancers of the liver, lung, colorectum, breast and cervix were the major cancers 2008-2012, although variations in the profiles of cancer were observed, with a very high incidence of liver cancer seen among males in Phrae, corresponding to one in 11 men developing the disease in a lifetime. Based on data from Lampang and Chiang Mai 1993-2012, rates of lung and cervical cancer incidence have declined, while liver, colorectal and breast cancer incidence have been increasing up to 2012. A more detailed investigation of the incidence trends for specific cancer sites and subtypes at the local level are crucial to the monitoring and evaluation of the cancer control interventions implemented within the Thai national cancer control programme (NCCP). Priority should be given to extend the capacity of the new registries in northern Thailand, ensuring improvement in quality and utilization of the data to drive epidemiologic research and cancer control.

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Risk Factors for Rectal Cancer and Methylenetetrahydrofolate Reductase Polymorphisms in a Population in Northeast Thailand

Cited by 8 publications

References 28 publications

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

XRCC1 Gene Polymorphism, Diet and Risk of Colorectal Cancer in Thailand

Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site

Cancer incidence in northern Thailand: Results from six population‐based cancer registries 1993–2012

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