Risk factors for prolonged QTc among US adults: Third National Health                     and Nutrition Examination Survey

Benoit, Stephen R.; Mendelsohn, Aaron B.; Nourjah, Parivash; Staffa, Judy A.

doi:10.1097/01.hjr.0000173110.21851.a9

Cited by 129 publications

(114 citation statements)

References 44 publications

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“…We found a prolonged QTc interval in nearly 47% of our cohort IBD population, which was clearly higher, than that (8.7%) in the general population published in previous studies (3). A study utilizing the Third National Health and Nutrition Examination Survey demonstrated that the prevalence of QTc interval prolongation in individuals aged >40 years was 6.3% (21). Similarly in the Framingham study Goldberg et al (22), the prevalence of QTc interval prolongation between the age groups of 30 and 62 years was 5.4%.…”

Section: Discussioncontrasting

confidence: 43%

“…The main risk factors implicated in QT interval prolongation appear to be hypocalcemia, hyperkalemia, hypomagnesaemia, diabetes, hypertension, female gender, higher BMI, cardiac disease, gene mutations, medications (antiarrhythmics, antibiotics, antipsychotics, and antidepressants) (21,24,25). In our study, except for higher BMI, which was significantly associated with prolonged QTc interval (26.2±5.9 vs. 29.7±6.9, p=0.005), other risk factors, such as female gender, hypertension, CAD, Table 4.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of QT interval prolongation in inflammatory bowel disease

Pattanshetty

Gajulapalli

Anna

et al. 2016

Turk J Gastroenterol

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Prevalence of QT interval prolongation in inflammatory bowel disease

Pattanshetty

Gajulapalli

Anna

et al. 2016

Turk J Gastroenterol

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“…A higher prevalence of QTc prolongation in women than in men has been previously reported (8). We have also recently reported a higher prevalence of ECGdiagnosed left ventricular hypertrophy in women compared with men with type 1 (18) or type 2 (22) diabetes.…”

Section: Results -mentioning

confidence: 53%

“…The pathogenesis of QTc prolongation remains poorly understood, although cross-sectional studies suggest a role for several risk factors, including female sex (8), glycemic control (9), ischemic heart disease (10), gene mutations (11), and blood pressure (12). The identification of risk factors for prolonged QTc is of clinical relevance because it would enable the targeting of people at high risk of cardiovascular events and, potentially, the application of risklowering strategies.…”

mentioning

confidence: 99%

Incidence and Risk Factors of Prolonged QTc Interval in Type 1 Diabetes

Giunti

Bruno²,

Lillaz³

et al. 2007

Diabetes Care

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OBJECTIVE -Corrected QT (QTc) prolongation is predictive of cardiovascular mortality in both the general and diabetic populations. As part of the EURODIAB Prospective Complication Study, we have assessed the 7-year incidence and risk factors of prolonged QTc in people with type 1 diabetes. RESEARCH DESIGN AND METHODS-A total of 1,415 type 1 diabetic subjects, who had normal QTc at baseline, were reanalyzed after the 7-year follow-up period. QTc Ͼ0.44 s was considered abnormally prolonged.RESULTS -Cumulative incidence of prolonged QTc was 18.7%, which is twofold higher in women than in men (24.5 vs. 13.9%, P Ͻ 0.0001). At the baseline examination, incident cases were older and less physically active than nonincident cases, had higher mean values of systolic blood pressure and HDL cholesterol, and had higher frequencies of hypertension, coronary heart disease, and distal symmetrical polyneuropathy. In multivariate logistic regression analyses, female sex and higher values of A1C and systolic blood pressure were associated with the risk of prolonged QTc, whereas physical activity and BMI within the range of 21.5-23.2 kg/m 2 were protective factors. In women, association with modifiable factors, particularly BMI, was stronger than in men.CONCLUSIONS -In type 1 diabetic subjects from the EURODIAB cohort, female sex, A1C, and systolic blood pressure are predictive of prolonged QTc, whereas physical activity and BMI within the range of 21.5-23.2 kg/m 2 play a protective role. These findings are clinically relevant, as they may help to identify subjects at higher risk for prolonged QTc, as well as provide potential targets for risk-lowering strategies.

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“…The standard 12-lead electrocardiogram (ECG), which provides information about the QT interval, is a representation of depolarization and repolarization of the ventricular myocytes. Thus, it is assumed that the increased QTd observed in cardiac diseases with heterogeneous ventricular recovery times reflects the disparity of ventricular recovery times (8,9). The QTd is a simple, inexpensive and noninvasive method to measure underlying dispersion recovery of ventricular excitability.…”

mentioning

confidence: 99%

Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization

KaraveliogAAlu¹,

Karapınar²

2015

Curr Res Cardiol

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69Y Karavelioğlu, H Karapınar, M Kalçık, Z Küçükdurmaz, S Özkurt, T Sarak. Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization. Curr Res Cardiol 2015;2(2):69-72.BaCKgRound: The effects of varenicline, an effective drug for smoking cessation, on atrioventricular and ventricular conductance remain unknown. oBjeCTive: To evaluate the effects of varenicline on heart rate, PR interval, QT interval and QT dispersion (QTd). MeTHodS: A total of 60 smokers were prospectively enrolled in the present study. Twelve-lead electrocardiogram recordings were obtained for all subjects before and on the 15th day of drug administration. Electrocardiograms were recorded at an amplitude of 20 mm/mV and a sweep speed of 50 mm/s. ReSulTS:The mean (± SD) age of the volunteers was 38±10 years. Thirtyfour (57%) were male. Fourteen (23%) had hypertension, eight (13%) had diabetes and six (10%) had chronic obstructive pulmonary disease. The mean heart rate was 74.7±13.3 beats/min, and mean systolic and diastolic blood pressures on admission were 122.3±14.3 mmHg and 76.5±10.2 mmHg, respectively. Heart rate, and systolic and diastolic blood pressures did not change with varenicline treatment. Varenicline treatment resulted in limited prolongation in PR interval, which appropached significance (163.5±18.3 ms versus 168.2±17.9 ms; P=0.053), while RR interval (796.3±117.4 ms versus 798.3±123.7 ms; P=0.926), QT interval (384.1±17.5 ms versus 383.4±20.9 ms; P=0.852) and QTd (52.6±14.9 ms versus 52.2±14.9 ms; P=0.919) were not significantly changed. ConCluSion: Varenicline had a limited effect on atrioventricular conduction, while it had no effect on heart rate, QT interval and QTd. Further studies are needed to prove the effects of varenicline on the conduction system of the heart, especially on PR interval.

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Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey

Abstract: Healthcare practitioners should be aware that a prolonged QTc interval is a potential indicator of cardiovascular risk, and should exercise caution in prescribing potentially QT-prolonging medications to certain patients.

Cited by 129 publications

References 44 publications

Prevalence of QT interval prolongation in inflammatory bowel disease

Prevalence of QT interval prolongation in inflammatory bowel disease

Incidence and Risk Factors of Prolonged QTc Interval in Type 1 Diabetes

Short-term effects of varenicline therapy on homogeneity of heart rate, atrioventricular conduction and ventricular repolarization

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