Prevalence of QT interval prolongation in inflammatory bowel disease

Pattanshetty, Deepak; Gajulapalli, Rama Dilip; Anna, Kiran; Biyyani, Raja Shekhar Sappati

doi:10.5152/tjg.2015.150349

Cited by 10 publications

(13 citation statements)

References 49 publications

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“…The results of our study had showed considerably increased dispersion of the QT and QTc parameters in pediatric IBD patients in comparison with controls, which was compatible with previous observations in adult IBD patients [31–33]. The values of QTdisp (44.33 ± 7.55 ms) were significantly higher than those in the control group (32.55 ± 6.77 ms).…”

Section: Discussionsupporting

confidence: 92%

Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission

Bornaun

Yılmaz

Kutluk

et al. 2017

BioMed Research International

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Objectives. Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) with unclear underlying aetiologies. Severe cardiac arrhythmias have been emphasised in a few studies on adult IBD patients. This study aimed to investigate the alteration of the P-wave and QT interval dispersion parameters to assess the risk of atrial conduction and ventricular repolarisation abnormalities in pediatric IBD patients. Patients and Methods. Thirty-six IBD patients in remission (UC: 20, CD: 16) aged 3–18 years and 36 age- and sex-matched control patients were enrolled in the study. Twelve-lead electrocardiograms were used to determine durations of P-wave, QT, and corrected QT (QTc) interval dispersion. Transthoracic echocardiograms and 24-hour rhythm Holter recordings were obtained for both groups. Results. The P-wave dispersion, QT dispersion, and QTc interval dispersion (Pdisp, QTdisp, and QTcdisp) were significantly longer in the patient group. The mean values of Pminimum, Pmaximum, and QTcminimum were significantly different between the two groups. The echocardiography and Holter monitoring results were not significantly different between the groups. Furthermore, no differences in these parameters were detected between the CD and UC groups. Conclusion. Results suggest that paediatric IBD patients may carry potential risks for serious atrial and ventricular arrhythmias over time even during remission.

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Section: Discussionsupporting

confidence: 92%

Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission

Bornaun

Yılmaz

Kutluk

et al. 2017

BioMed Research International

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“…8,9 Yorulmaz et al and Deepak J et al found same results showing autonomic dysfunction in IBS. 20,21 Akkus et al also showed prolongation of QTd and QTcd times for the QT dispersion in the patients with IBS and similar results were obtained in our study. 22…”

Section: Discussionsupporting

confidence: 91%

QT dispersion in irritable bowel syndrome

Varım¹,

Karacaer²,

Varım³

et al. 2019

Int J Res Med Sci

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Background: The pathogenesis of irritable bowel syndrome (IBS) has not been fully elucidated. The gastrointestinal tract have a well-differentiated intrinsic nervous system and also this system is connected with nervous system. The symptoms of IBS are related with autonomic nervous system (ANS). It was also possible to see cardiovascular symptoms due to this link. This link can influence QT dispersion (QTd). The aim of this case control study is to show the cardiac effects of IBS by changes in QTd.Methods: There were 56 newly diagnosed patients with IBS and 60 control subjects were included in this study. IBS was diagnosed using the new Roma IV Criterias. Standard 12-lead electrocardiogram (ECG) were taken in both two groups. QTd and corrected QTd (QTcd), QT max, QT min, QT avarage, Corrected QT (QTc) min, QTc max, QTc avarage values were calculated with Bazzet Formula from rest ECGs.Results: There were 56 newly diagnosed patients with IBS and 60 control subjects were included in the study (p:0.94). The mean age of the patients and control patients were 51.75±10.41 years and 48.41±9.72 (p: 0.53) years, respectively. QTd and corrected QTd (QTcd), QT max, QT min, QT mean, Corrected QT (QTc) min, QTc max, QTc mean values were calculated. QTd and QTcd values were found to be significantly higher in the patients with IBS (40.2±7.18; 34.1±6.18 / 52±9.8; 50.6±7.61 Msec, respectively). It is concluded that, QTd (p: 0.022) and QTcd (p: 0.032) were significantly incresased in the IBS.Conclusions: Activation of ANS in the patients with IBS can affect QT period in ECG.

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“…Figure 4 shows the PRISMA diagram summarizing the sequence of the literature selection. Seven studies reported on QTc interval [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Table 3 summarizes the results of the studies that measured the QTc interval in patients with IBD.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 4 shows the PRISMA diagram summarizing the sequence of the literature selection. Seven studies reported on QTc interval [27][28][29][30][31][32][33]. Table 3 There were no significant relationships between the QTc values and all the other baseline characteristics, i.e., gender, age, disease duration, type of IBD (UC or CD), and therapy.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…Notably, morbidity and mortality due to CVD are exclusively observed during active IBD flares. Studies based on electrocardiogram (ECG) findings indicate that patients with IBD are at a higher risk of developing QT interval abnormalities, in particular heart-rate-corrected QT interval (QTc) [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2020

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Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD.

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Prevalence of QT interval prolongation in inflammatory bowel disease

Cited by 10 publications

References 49 publications

Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission

Prolonged P-Wave and QT Dispersion in Children with Inflammatory Bowel Disease in Remission

QT dispersion in irritable bowel syndrome

Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

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