Risk factors for primary open-angle glaucoma in South Korea: the Namil study

Kim, Martha; Kim, Tae Woo; Park, Ki Ho; Kim, Joon Mo

doi:10.1007/s10384-012-0153-4

Cited by 108 publications

(115 citation statements)

References 22 publications

(35 reference statements)

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“…In this (ie, Korean) study, high-tension cases (88.5% of all cases) were primarily recruited, even though normaltension glaucoma (2.7%) is much more prevalent than high-tension glaucoma (0.8%) in the general Korean population. 37 In addition, the average intraocular pressure was 28.2 mm Hg, which was much higher than the average pressure in the previous Japanese study (15.5 mm Hg). 29 Although the effect of the Korean marker rs7098387 on high-tension POAG (OR ¼ 2.2 (1.5-3.1), P ¼ 0.00012) was not much different from that on total POAG (OR ¼ 2.0 (1.4-3.0), P ¼ 0.00038) in this study, it remains to be determined whether the rs7098387 and rs7081455 markers are separately associated with high-tension and normal-tension glaucoma, respectively.…”

Section: Discussioncontrasting

confidence: 51%

“…The demographic and clinical details of the study subjects are summarized in Table 1. The male/female ratio (1.6) was high in the case of this recruitment, as in the general POAG prevalence (gender ratio of 1.4) of Koreans, 37 but there was no attempt to match with control recruitment (gender ratio of 1.0), which would have necessitated an adjustment for gender in the susceptibility association tests.…”

Section: Study Participantsmentioning

confidence: 92%

“…The risk effect of the rs7098387 SNP was calculated according to a dominant rather than a recessive or additive genetic model because no 37), and the originally reported SNPs are in bold. The major and minor alleles are referred to as B and b, respectively, and the number of genotypes is shown.…”

Section: Methodsmentioning

confidence: 99%

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Expansive marker analysis replicating the association of glaucoma susceptibility with human chromosome loci 1q43 and 10p12.31

et al. 2013

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Three human chromosome loci (1q43, 10p12.31, and 12q21.31) were recently associated with the susceptibility to primary open-angle glaucoma (POAG) in a Japanese population; however, this was not replicated in three subsequent studies using South Indian, Afro-Caribbean, and Chinese populations. To identify genetic markers that are robustly associated across ethnic populations, numerous markers in addition to the six in the three reported loci were examined in this study. A total of 31 single-nucleotide polymorphism (SNP) markers were genotyped for 1115 Korean participants, and many neighboring SNPs were imputed using the Korean HapMap Project genotype data. Each SNP was statistically tested for association with POAG susceptibility by comparisons among 211 POAG patients with 904 unaffected controls. A strong and statistically significant association was found with a previously unreported SNP, rs7098387 (odds ratio, OR ¼ 2.0 (1.4-3.0), P ¼ 0.00038) at the 10p12.31 locus (where 11 SNPs were typed and 38 imputed) in contrast to the reported rs7081455, which was too poorly correlated with newly associated rs7098387 (r 2 ¼ 0.003, D 0 ¼ 0.40) to show association. Additionally, a modest association was observed with the reported rs693421 (OR ¼ 1.4 (1.1-1.7), P ¼ 0.0082) and several other SNPs located within and around ZP4 at the 1q43 locus (10 SNPs typed and 14 imputed). However, no association was observed with the reported rs7961953 SNP or any other SNPs at the 12q21.31 locus, upstream of TMTC2 (10 SNPs typed and 29 imputed). Accordingly, POAG susceptibility association was replicated using rs7098387 (C) rather than rs7081455 (T) at the 10p12.31 locus and additionally with rs693421 (T) at the 1q43 locus.

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Section: Discussioncontrasting

confidence: 51%

Section: Study Participantsmentioning

confidence: 92%

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Expansive marker analysis replicating the association of glaucoma susceptibility with human chromosome loci 1q43 and 10p12.31

et al. 2013

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“…The high prevalence of POAG with normal IOP in Chinese people was reported in the Liwan eye study, which obtained data similar to that found in Japan and Korea. 19,20 Furthermore, as in the Tajimi study, the low average IOP in POAG subjects and the high prevalence of POAG with normal IOP do not mean that IOP was not related to POAG. The average IOP in POAG with high or normal IOP subjects was 25.3 6 6.2 mm Hg or 15.2 6 2.3 mm Hg, respectively.…”

Section: Discussionmentioning

confidence: 84%

The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

Zhong

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We evaluated the prevalence of glaucoma in adults of the Bai Nationality populations in rural China. METHODS.A population-based survey of Chinese Bai Nationality aged ‡50 years from randomly selected block groups in southwestern China was conducted. Eligible persons were invited to local examination sites for a complete ophthalmic examination. Glaucoma was diagnosed using the International Society of Geographical and Epidemiological Ophthalmology Classification scheme.RESULTS. In the study, 2133 subjects (77.8% participation rate) were examined, with a crude prevalence of all glaucoma of 2.2% (95% confidence interval [CI] 1.6%-2.9%). Primary open angle glaucoma (POAG) was found in 1.0% of cases (95% CI 0.6%-1.6%) and primary angle-closure glaucoma (PACG) in 0.9% (95% CI 0.6%-1.4%). The prevalence of all glaucoma was significantly higher in older people and women. Mean intraocular pressure (IOP) was 16.17 6 3.74 mm Hg (97.5th and 99.5th percentiles, 24 mm Hg and 30 mm Hg, respectively). The mean vertical cup-to-disc ratio (VCDR) was 0.43 6 0.17 (97.5th and 99.5th percentiles 0.7 and 0.8, respectively). Unilateral blindness was found in 80% of PACG, compared to only 36.3% of POAG cases.CONCLUSIONS. Prevalence of POAG is similar to PACG in the ethnic Bai population living in rural southwestern China. PACG has a worse visual impairment and prognosis compared to POAG. (Invest Ophthalmol Vis Sci. 2012;53:3221-3225)

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“…In East Asia, most patients with open-angle glaucoma have normal tension glaucoma (NTG) (Suzuki et al 2006;Kim et al 2011;Liang et al 2011). Therefore, other etiological factors other than elevated IOP seem to be important for the pathogenesis of glaucoma, particularly in these populations (David et al 1985;Mitchell et al 1999;Wong et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Difference in the posterior pole profiles associated with the initial location of visual field defect in early‐stage normal tension glaucoma

Choi

Park

2014

Acta Ophthalmologica

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ABSTRACT.Purpose: To identify the differences in posterior pole profiles between early normal tension glaucoma (NTG) patients with an initial central visual field (VF) loss and those with a peripheral VF loss. Methods: Normal tension glaucoma patients with parafoveal scotoma (PFS; within a central 10°of fixation; superior, n = 47; inferior, n = 24) and peripheral nasal step (PNS; VF defect in the nasal meridian outside 10°of fixation; superior, n = 27; inferior, n = 32) in either hemifield were enrolled, if their mean deviation was greater than À10 decibels (dB). Disc tilt (tilt ratio), disc torsion, area of peripapillary atrophy and disc-foveal angle (angle between a horizontal line through the disc centre and the line connecting the fovea and the disc centre) were analysed from red-free fundus photographs. Results: The mean disc-foveal angles (shortest diameter) in PNS and PFS groups were 6.2 AE 4.5 and 7.7 AE 4.0°, respectively. In multivariate analysis, eyes with PFS were associated with a greater disc-foveal angle, compared with PNS (p = 0.042). In subgroup analysis, superior PFS group showed greater discfoveal angle compared with inferior PFS group (p = 0.018). In the PNS group, the direction of disc torsion was associated with superior and inferior hemifield defects (p = 0.004). Conclusions: The posterior pole profiles were different in NTG patients according to their location of damage. Disc-foveal angle was the major determinant of the VF location in patients with VF loss at the central region and disc torsion in patients with loss at the peripheral region.

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Risk factors for primary open-angle glaucoma in South Korea: the Namil study

Abstract: In the Namil study, higher IOP, older age and a history of thyroid disease were significant risk factors for POAG.

Cited by 108 publications

References 22 publications

Expansive marker analysis replicating the association of glaucoma susceptibility with human chromosome loci 1q43 and 10p12.31

Expansive marker analysis replicating the association of glaucoma susceptibility with human chromosome loci 1q43 and 10p12.31

The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

Difference in the posterior pole profiles associated with the initial location of visual field defect in early‐stage normal tension glaucoma

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