Risk factors for pre‐eclampsia in Mulago Hospital, Kampala, Uganda

Kowal, Paul; Wamuyu-Maina, Gakenia; Bimenya, G. S.; Tumwesigye, Nazarius Mbona; Wandabwa, Julius; Okong, Pius

doi:10.1111/j.1365-3156.2011.02926.x

Cited by 46 publications

(53 citation statements)

References 51 publications

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“…In addition, previous studies have revealed side-to-side differences in uteroplacental Doppler flow in pregnancies with unilateral placentas as well as the relationship between abnormal Doppler measurements and pre-eclampsia (13)(14)(15)(16)(17)(18)(19)(20)(21). However, reports on the direct association between placental location and development of pre-eclampsia, regardless of confounding factors (22), are limited.…”

Section: Introductionmentioning

confidence: 94%

Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Keshavarz

Sadeghian

Hakemi

et al. 2017

J Obstet Gynecol Cancer Res

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Background: Pre-eclampsia complicates 5% to 8% of all pregnancies and annual incidence of pre-eclampsia is about 5% of all pregnancies around the world and is a significant cause of both maternal and fetal mortality and morbidity if left untreated. Objectives: According to previous studies, blood supply distribution within the uterus is not similar in central compared with lateral sites, thus site of implantation and the resulting location of the placenta are likely to have a profound effect on the pregnancy outcome. Methods: The researchers conducted a case-control study over 1-year period at a referral obstetric hospital in the south of Tehran. Overall, 121 females with three degrees of pre-eclampsia were considered as cases and 258 females with normal pregnancy were the controls. The females were aged 20 to 40 years old and their gestational age was between 14 and 26 weeks. Results:The researchers recorded the participants' blood pressures and locations of placenta during this period with consideration of their past and present obstetric history as well as medical and familial history. As a result, pregnancies complicated by pre-eclampsia were more commonly associated with lateral placentation in the second trimester when compared with non-preeclampsia pregnancies. Discussion: This study suggests that placental location, which is easily assessed at middle trimester of pregnancy by routine screening ultrasonography, is an ideal predictive test for evaluating the risk of developing pre-eclampsia.

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Section: Introductionmentioning

confidence: 94%

Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Keshavarz

Sadeghian

Hakemi

et al. 2017

J Obstet Gynecol Cancer Res

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“…Recently, it has been shown that placenta previa is associated with low frequencies of pre-eclampsia and low maternal blood pressure (Kiondo et al, 2012). However, there are few published studies – with inconsistent findings – on the association between placenta previa and pre-eclampsia.…”

Section: Introductionmentioning

confidence: 99%

Placenta Previa and Pre-Eclampsia: Analyses of 1645 Cases at Medani Maternity Hospital, Sudan

Adam¹,

Haggaz²,

Mirghani³

et al. 2013

Front. Physiol.

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A retrospective case-control study was conducted to investigate the risk factors for pre-eclampsia – including the protective effect of placenta previa – at Medani Maternity Hospital, Sudan. Medical files of the patients during the period 2003–2010 were reviewed for age, parity, education level, prenatal care, placenta previa, and hemoglobin level. Women with pre-eclampsia were the cases, and women with normal pregnancy were the controls. There were 54,339 singleton deliveries and 1765 women with pre-eclampsia in the hospital, giving the incidence of pre-eclampsia of 3.2%. The risk factors for pre-eclampsia were; women with age >35 years (OR = 1.4, 95% CI: 1.1–1.8), primiparity (OR = 3.3, 95% CI: 2.7–4.0), para >5 (OR = 3.1, 95% CI: 2.4–4.0), and anemia (OR = 3.3, 95% CI: 2.8–3.9). The risk of pre-eclampsia was inversely increased with education level and prenatal care attendance. The prevalence of placenta previa was 0 (0%) and 55 (3.3%), P < 0.001 in pre-eclamptic and control women, respectively. Placenta previa was a significant protective factor of pre-eclampsia (OR = 0.3, 95% CI: 0.1–0.7). Although, the socio-demographic risk factors for pre-eclampsia observed among women at Medani hospital were similar to those found in other settings; placenta previa was associated with decreased incidence of pre-eclampsia.

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“…We assumed that the persistence of hypertension would be 42.6% as was found in a study by Kaze et.al (15) and parity as a biggest risk factor for preeclampsia with an odds ratio of 3.71 as was found in a study in Mulago hospital (16). With these estimates a sample size of 97 participants would be sufficient with power of 80% at confidence level of 95% taking in account of the anticipated loss to follow up of 5%.…”

Section: Methodsmentioning

confidence: 87%

Postpartum trend in blood pressure and renal function in women with severe preeclampsia and eclampsia: A prospective cohort-study at Mulago hospital, Kampala, Uganda

Muteke

Beyeza

Musaba³

et al. 2019

Preprint

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2Background 3 Preeclampsia/Eclampsia is a multisystem disorder of pregnancy with kidney involvement. Our 4 objective was to assess the postpartum trend in blood pressure, renal function and proteinuria 5 and, to investigate their predictors in Ugandan women with severe preeclampsia and eclampsia. 6 Methods 7This was a prospective cohort study that involved 97 women with severe preeclampsia and 8 Eclampsia, conducted at Mulago National referral hospital from August 2017 to April 2018. The 9 clinical and laboratory variables were collected from the women on day1, 7, 21 and day 42 after 10 delivery. Kaplan-Meier Survival analysis, Cox-proportional Regression and Log-Rank tests were 11 used to compare the baseline and the follow-up variables with changes in blood pressure, renal 12 function and urine protein.13 Results. 14 Most women (93.8%) recovered from hypertension within 6 weeks of childbirth with the mean 15 time to resolution of 2.49 weeks (95% CI: 2.13-2.82). About 81% of the women recovered their 16 renal function and the mean time to recovery was 24.54 days (95% CI: 20.14-28.95). Proteinuria 17 resolved in approximately 84% of the women and the mean time resolution of urine protein of 18 32.85 days (95% CI: 30.31-35.39). Having multiple pregnancy versus a singleton pregnancy was 19 associated with persistence of hypertension six weeks after child birth (P-value = 0.013).42 Keys words 43 Preeclampsia, Hypertension, Proteinuria, Renal dysfunction, Resolution, Postpartum. 44 4 46 130 glomerular filtration rate using current serum creatinine, patient race, gender and age of the 131 participant (17). The MDRD calculator was used for determining and classifying the estimated 132 glomerular filtration https://patient.info/doctor/estimated-glomerular-filtration-rate-gfr-calculator 133 Outcomes 134The primary outcome was time to resolution of the blood pressure. Secondary outcomes were 135 time to recovery of renal function and disappearance of proteinuria. The blood pressure was 136 considered normal when it was less than 140/90 mmHg without any antihypertensive 137 medications for at least one week. 138Serum creatinine level and estimated glomerular filtration were measured at every visit and were 139 considered normal when the estimated glomerular filtration was ≥ 90 mL/min/1.73 m 2

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Risk factors for pre‐eclampsia in Mulago Hospital, Kampala, Uganda

Cited by 46 publications

References 51 publications

Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Placenta Previa and Pre-Eclampsia: Analyses of 1645 Cases at Medani Maternity Hospital, Sudan

Postpartum trend in blood pressure and renal function in women with severe preeclampsia and eclampsia: A prospective cohort-study at Mulago hospital, Kampala, Uganda

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