Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Keshavarz, Elham; Sadeghian, Afarin; Hakemi, Ali Ganjalikhan; Khtibi, Fatemeh Talei

doi:10.5812/jogcr.11945

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…On the other hand, the lateral location of the placenta indicates an increased likelihood of developing pe [38], which is also reflected in our results. Our results coincide with those of other authors who have found that the use of mid-trimester ultrasound screening techniques can predict the risk of pe [37]. Some authors link placental laterality and the high risk of hypertension in pregnant women [35,36], which also coincides with our findings.…”

Section: Discussionsupporting

confidence: 93%

The model of screening for preeclampsia in the second and third trimesters of gestation

et al. 2023

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Purpose: Preeclampsia (PE) is a specific syndrome of multiple organ insufficiency in case of pregnancy, which is included in the panel of major obstetric syndromes and is among the main causes of maternal morbidity and mortality in the whole world. Material and methods: We conducted a prospective cohort study of 91 pregnant women to evaluate the effectiveness of integrated use of maternal risk factors (2019 International Federation of Gynecology and Obstetrics recommendations), placenta location (ultrasound at 18-20 weeks of gestation), and serum cystatin C (at 18-36 weeks of gestation) in screening for pe in the second and third trimesters of gestation. Results: In the subgroup of pregnant women with cystatin C levels greater than 1.0 mg/L (27 women), PE developed in 26 women, which is 96.29% in percentage terms. When calculating GFR for cystatin C in a group with PE there was a significant violation of the renal filtration system -52.46±2.08 (95% CI, 48.39-56.54), while in healthy group the indicator is within normal limits -97.6±1.64 (95% CI, 94.38-100.82). In the analysis of the ratio of cystatin C levels more than 1.0 mg / l and the development of PE, a sensitivity of 98.46%, specificity of 100% and accuracy of 98.9%, p<0.001. Conclusions: The data show that the combined model of maternal factors, ultrasound of the placenta and serum cystatin C, is prognostically effective in pregnant women in the second and third trimesters of gestation and is a reliable marker for the development of pe.

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Section: Discussionsupporting

confidence: 93%

The model of screening for preeclampsia in the second and third trimesters of gestation

et al. 2023

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“…18 In a retrospective study by Keshavarz E et al, analysis showed lateral placenta was associated with preeclampsia in 47.6% (20 out of 42) of cases while other locations were associated with preeclampsia in 30% (101 out of 337) (P Value=0.02, Odds ratio: 2.1, 95% confidence interval: 1.1 -4.1). 19 In a study by Pai MV, Pillai J, a total of 426 unselected singleton pregnant women attending the antenatal clinic were included. A total of 71 women developed preeclampsia, of which 52 (74%) had unilaterally located placenta at 20-24 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…The mentioned data revealed that preeclampsia pregnancies had more antepartum and intrapartum complications than the non-preeclampsia group. 19 Also, caesarean section and low birth weight were more commonly seen in the lateral placenta group compared to the central placenta group.…”

Section: Table 6 Depicts Distribution Of Patients Developing Preeclampsia On the Basis Of Severity Of Diseasementioning

confidence: 90%

Correlation between placental location and development of preeclampsia

Uikey

Gurwani

Tajne³

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia occurs in presence of placenta. Blood supply distribution within the uterus is not similar in central versus lateral sites implicating that, the site of placenta is likely to have a profound eﬀect on the pregnancy outcome. In the light of these observations, a prospective study was designed to find out if the lateral location of placenta as seen by ultrasound between 18-24 weeks of gestation can be used to predict the development of preeclampsia.Methods: This prospective study was conducted in the department of Obstetrics and Gynaecology in IGGMC, Nagpur between January 2017 and June 2018. Pregnant women, with singleton pregnancy and without any risk factor, attending the antenatal clinic were subjected to USG between 18-24 weeks of gestation. Accordingly, patients were divided into 2 groups, 51 with lateral placenta and 51 with central placenta. All 102 women were followed till term. The end point of the study was development of preeclampsia i.e. BP >140/90 and urine albumin >300 mg in 24 hours sample. The data obtained was analysed using appropriate statistical tests.Results: Out of 102 patients, 80.9% were from lateral placenta group and only 19.1% were from central placenta. Sensitivity of this as screening test for preeclampsia was 80.9% while specificity was 58%, Odds ratio being 5.875. In predicting preeclampsia, lateral placenta had a meaningful effect with p value <0.001.Conclusions: Placental laterality, as determined by USG between 18-24 weeks of gestation, is a simple and cost-effective screening test for development of preeclampsia.

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Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Cited by 2 publications

References 18 publications

The model of screening for preeclampsia in the second and third trimesters of gestation

The model of screening for preeclampsia in the second and third trimesters of gestation

Correlation between placental location and development of preeclampsia

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