Risk factors for postoperative recurrence of non‐B non‐C hepatocellular carcinoma

Shinkawa, Hiroji; Uenishi, Takahiro; Takemura, Shigekazu; Ohba, Kazuki; Ogawa, Michio; Ichikawa, Tsuyoshi; Kodai, Shintaro; Yamamoto, Takatsugu; Tanaka, Hiromu; Kubo, Shoji

doi:10.1007/s00534-009-0186-3

Cited by 11 publications

(6 citation statements)

References 37 publications

(50 reference statements)

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“…However, the literature contains no reports on the prognostic factors for postoperative recurrence and OS in CR-HCC. Given the findings of some previous studies [ 5 , 11 , 15 – 20 ], we predicted for our study that only the prognostic factors for CR-HCC would be tumor factors and that background liver function would not be prognostic because the liver function of CR-HCC patients is better than that of B-HCC/C-HCC patients. Unexpectedly, however, we found that background liver function was also a prognostic factor for CR-HCC as well as B-HCC/C-HCC.…”

Section: Discussionmentioning

confidence: 96%

Long-term prognosis after resection of cryptogenic hepatocellular carcinoma

et al. 2015

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BackgroundWe investigated the patterns and predictors of recurrence and survival in cryptogenic non-B, non-C, non-alcoholic hepatocellular carcinoma (CR-HCC). We compared the findings with those hepatitis virus B (B) and hepatitis virus C (C)-HCC. CR-HCC does not include HCC developed on NASH.MethodsFrom 1990 to 2011, of 676 patients who underwent primary curative liver resection as initial therapy for HCC at our institution, 167 had B-HCC, 401 had C-HCC, and 62 had CR-HCC. Differences between three groups were analyzed using the Chi-squared test. Cumulative overall survival (OS) and disease-free survival (DFS) were determined by the Kaplan-Meier method, prognostic factors involved in OS/DFS were evaluated by univariate analysis using the log-rank test, and stepwise Cox regression analysis.ResultsLiver function was better in CR-HCC than in B/C-HCC, and mean tumor size was larger in CR-HCC than in B/C-HCC. In CR-HCC, OS was equivalent to that of B/C-HCC, and DFS was equivalent to that of B-HCC. Both tumor-related factors and background liver function appeared to be prognostic factors for three groups.ConclusionOur findings indicate that the probability of survival of advanced CR-HCC was not longer than that of B/C-HCC. Given our findings, a postoperative follow-up protocol for CR-HCC should be established alongside that for B/C-HCC.

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Section: Discussionmentioning

confidence: 96%

Long-term prognosis after resection of cryptogenic hepatocellular carcinoma

et al. 2015

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“…Our research identi ed that the etiology of NBNC-AFP(-)-HCC in patients in China was related to obesity, diabetes, metabolic syndrome, and NAFLD, which is consistent with existing reports [20] . Some factors are associated with the non-alcoholic steatohepatitis (NASH) and liver brosis, such as age, obesity, hypertension, type II diabetes, ALT, S/T >1, and decreased platelet count [21,22] . A series of studies con rmed that obesity and diabetes were independent risk factors for HCC [23] .…”

Section: Discussionmentioning

confidence: 99%

Influence of AFP On Surgical Outcomes in Non-B Non-C Patients With Curative Resection For Hepatocellular Carcinoma

Tan

Zeng²,

Zhou

et al. 2021

Preprint

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Objective: To study the clinical and prognostic features of non-B non-C alpha-fetoprotein (AFP) (-)-hepatocellular carcinoma (HCC) (NBNC-AFP(-)-HCC), and the relationship between the prognostic features of HCC and hepatitis B virus surface antigen (HBsAg) status and AFP. Methods: We enrolled 227 patients underwent hepatic resection for HCC between January 1998 and December 2007 in Sun Yat-Sen University Cancer Center, all of them were diagnosed with HCC by pathology. All patients were stratified into one of four groups (B-AFP(+)-HCC, B-AFP(-)-HCC, NBNC-AFP(+)-HCC, and NBNC-AFP(-)-HCC) according to AFP levels and HBsAg status. The clinicopathologic and survival characteristics of NBNC-AFP(-)-HCC patients were compared with all other three groups. Results: Out of the 105 NBNC-HCC patients, 43 patients (40.9%) were AFP-negative HCC. There were some differences in factors between the B-AFP(+) and NBNC-AFP(-) patients, such as age, body mass index (BMI), diabetes, and ALT (P<0.05). On univariate analysis, tumor size, secondary tumor, and portal invasion were prognostic factors for overall survival (OS) and disease-free survival (DFS) (P<0.05). Cox multivariate regression analysis suggested that tumor size and tumor number (P<0.05) were independent predictors. In addition, compared with that in the B-AFP(+)-HCC, B-AFP(-)-HCC, and NBNC-AFP(+)-HCC groups, the NBNC-AFP(-)-HCC patients had the best DFS (P<0.05). Compared with that in the B-AFP(+)-HCC and NBNC-AFP(+)-HCC groups, the NBNC-AFP(-)-HCC patients had better OS(P<0.05), and survival rates were similar to those of B-AFP(-)-HCC patients. Conclusion: NBNC-AFP(-)-HCC patients had a relatively favorable prognosis. It can serve as a useful marker in predicting the risk of tumor recurrence in the early stages.

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“…In the present study, we demonstrated that serum Alb is a prognostic factor for OS and serum Alb and AFP for DFS using uni-and multivariate analyses. Until now, reported prognostic factors in patients with NBNC-HCC after hepatic resection include tumor diameter, multiple tumors, portal invasion and curative resection with an adequate surgical margin (13,18), which, however, remain controversial.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcome of Surgical Patients with Non-B Non-C Hepatocellular Carcinoma

Wakiyama

Matsumoto

Haruki

et al. 2017

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Risk factors for postoperative recurrence of non‐B non‐C hepatocellular carcinoma

Abstract: Curative resection with adequate surgical margins for single non-B non-C hepatocellular carcinoma can achieve a good outcome.

Cited by 11 publications

References 37 publications

Long-term prognosis after resection of cryptogenic hepatocellular carcinoma

Long-term prognosis after resection of cryptogenic hepatocellular carcinoma

Influence of AFP On Surgical Outcomes in Non-B Non-C Patients With Curative Resection For Hepatocellular Carcinoma

Clinical Features and Outcome of Surgical Patients with Non-B Non-C Hepatocellular Carcinoma

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