Clinical Features and Outcome of Surgical Patients with Non-B Non-C Hepatocellular Carcinoma

Wakiyama, Shigeki; Matsumoto, Michinori; Haruki, Koichiro; Gocho, Takeshi; Sakamoto, Taro; Shiba, Hiroaki; Futagawa, Yasuro; Ishida, Yuichi; Yanaga, Katsuhiko

doi:10.21873/anticanres.11682

Cited by 7 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…of studies No. of patients RR/MD 95% CI a Test for overall effect Heterogeneity P P I 2 (%) Age (years) NBNC-HCC versus B-HCC 23 [ 9 – 11 , 14 , 15 , 21 – 25 , 28 – 30 , 32 , 33 , 35 – 40 , 43 , 46 ] 7830 10.04 8.55, 11.53 < 0.00001 < 0.00001 92 NBNC-HCC versus C-HCC 21 [ 9 – 11 , 14 , 15 , 21 – 25 , 28 – 30 , 32 , 33 , 35 – 37 , 39 , 40 , 43 ] 14,317 0.19 -1.12, 1.50 0.78 < 0.00001 93 NBNC-HCC versus BC-HCC 6 [ 9 , 11 ...…”

Section: Resultsmentioning

confidence: 99%

“…of studies No. of patients RR/MD a 95% CI Test for overall effect Heterogeneity P P I 2 (%) ALT (U/L) NBNC-HCC versus B-HCC 14 [ 9 , 11 , 14 , 22 , 24 , 25 , 29 , 32 , 33 , 38 , 39 , 43 , 45 ] 2126 -9.62 -14.08, -5.17 < 0.0001 < 0.0001 68 NBNC-HCC versus C-HCC 12 [ 9 , 11 , 14 , 22 , 24 , 25 , 29 , 32 , 33 , 39 , 40 , 43 ] 3100 -25.04 -34.95, -15.13 < 0.00001 < 0.00001 93 NBNC-HCC versus BC-HCC 4 [ 9 , 11 , 24 , 29 ] 213 -29.3...…”

Section: Resultsmentioning

confidence: 99%

“…More and more studies demonstrated nonalcoholic steatohepatitis (NASH) and metabolic syndrome, including diabetes mellitus and obesity, were significant risk factors in the development of NBNC-HCC [ 2 , 40 , 43 ]. In a previous study, the BMI ≥ 23 kg/m 2 was even regarded as an important factor which influenced DFS of HCC patients [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis

Yu,

Zhi,

et al. 2023

BMC Gastroenterol

View full text Add to dashboard Cite

Background The incidence of HBV-negative and HCV-negative hepatocellular carcinoma (NBNC-HCC) is significantly increasing. However, their clinicopathologic features and prognosis remain elucidated. Our study aimed to compare the clinicopathologic characteristics and survival outcomes of NBNC-HCC with hepatitis virus-related HCC. Method A literature review was performed in several databases, including PubMed, Embase, Cochrane Library and Web of Science, to identify the studies comparing NBNC-HCC with HBV-positive HCV-negative HCC (B-HCC), HBV-negative HCV-positive (C-HCC) and/or HBV-positive HCV-positive HCC (BC-HCC). The clinicopathologic characteristics and survival outcomes were extracted and pooled to access the difference. Results Thirty-two studies with 26,297 patients were included: 5390 patients in NBNC-HCC group, 9873 patients in B-HCC group, 10,848 patients in C-HCC group and 186 patients in BC-HCC group. Patients in NBNC-HCC group were more liable to be diagnosed at higher ages, but with better liver functions and lighter liver cirrhosis. Comparing to B-HCC and C-HCC groups, although NBNC-HCC group was prone to have larger tumor sizes, it did not have more advanced tumors. Meanwhile, there were no significant differences in both 5-year and 10-year disease-free survival and overall survival between NBNC-HCC group and B-HCC or C-HCC group. Conclusions Our meta-analysis revealed patients with NBNC-HCC had as worse prognosis as those with hepatitis virus-related HCC. More attention should be paid on patients with non-alcoholic steatohepatitis or metabolic syndromes to prevent the incidence of NBNC-HCC.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis

Yu,

Zhi,

et al. 2023

BMC Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Several studies have investigated the clinicopathological characteristics and prognosis of patients with NBNC-HCC following hepatectomy. The characteristic features of patients with NBNC-HCC are older age (similar to those with HCV-HCC), increased incidence of hypertension, DM, heavy alcohol consumption, and large tumors, and a reduced incidence of liver cirrhosis (21)(22)(23)(24). In the current study, similar characteristics were revealed; in particular, the NBNC group patients had significantly lower serum albumin values than the HBV group patients and higher serum albumin values than the HCV group patients, despite a significantly lower incidence of liver cirrhosis in the NBNC group than the other groups.…”

Section: Discussionmentioning

confidence: 99%

Impact of Insulin Treatment on Prognosis of non-B non-C Hepatocellular Carcinoma After Hepatectomy

et al. 2021

View full text Add to dashboard Cite

Background/Aim: Several studies have reported that DM is closely associated with an increased incidence of hepatocellular carcinoma (HCC). To clarify the effects of diabetes mellitus (DM) and antidiabetic medications on the prognosis of patients with non-B non-C (NBNC) HCC following curative initial hepatectomy. Patients and Methods: HCC patients (n=156) were divided into three groups according to the presence or absence of chronic viral hepatitis: hepatitis B virus (HBV) group, hepatitis C virus (HCV) group, and NBNC group. The clinical characteristics and survival outcomes were compared. In the NBNC group, univariate and multivariate analyses were conducted to determine prognostic factors. Results: The NBNC group had a higher incidence of DM, ethanol intake, and large nodules than the other groups. Disease-free survival (DFS) was significantly worse in the NBNC group than in the HBV group. In the NBNC group, insulin treatment was an independent prognostic factor for DFS and overall survival (OS). Conclusion: Medications for DM that affect insulin resistance might be appropriate prognostic factors for NBNC-HCC.

show abstract

“…Clinically, the measurement of both AFP and DCP has been strongly recommended in the Clinical Practice Guidelines for Hepatocellular Carcinoma ( 14 reported to have relatively low serum AFP levels compared to hepatitis B-derived HCCs (15). Also, hepatitis C-infected livers usually have high serum AFP levels (16).…”

Section: Discussionmentioning

confidence: 99%

Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma

Hayashi

Yamada

Takano

et al. 2021

In Vivo

View full text Add to dashboard Cite

Background/Aim: Hepatocellular carcinoma (HCC) mainly develops in the damaged liver from hepatitis C virus (HCV) or hepatitis B virus (HBV) infection in Japan. On the other hand, the occurrence of HCCs derived from the liver without viral infection has recently been increasing. Our aim was to identify characteristics specific to HCCs with virus-infected liver (HCC-BC) or those with non-B-and non-C-infected liver (HCC-NBNC), Patients and Methods: We collected preoperative serum α-fetoprotein (AFP) and Des-Gamma-Carboxy Prothrombin (DCP), also known as PIVKA-II values from surgically resected HCC cases during 1994-2017 in our department. Results: Preoperative serum AFP values of HCC-BC cases (n=284) were higher compared to HCC-NBNC cases (n=88) (p=0.016), whereas serum DCP values of HCC-NBNC cases were higher compared to HCC-BC cases (p<0.001). Multivariable analyses indicated that abnormal serum AFP [hazard ratio (HR)=1.46, 95% conficdence interval (CI)=1.03-2.07, p=0.035) was one of the significant recurrence-free survival predictors of HCC-BC cases, while abnormal serum DCP (HR=4.99, 95%CI=1.91-13.01, p=0.001) was one of the significant recurrence-free survival predictors of HCC-NBNC cases. Conclusion: HCC-NBNC cases have a different tumor marker profile from HCC-BC cases. Elevated DCP could be both a diagnostic and prognostic marker of HCC-NBNC patients.

show abstract

Clinical Features and Outcome of Surgical Patients with Non-B Non-C Hepatocellular Carcinoma

Abstract: Surgical patients with NBNC-HCC often have concomitant DM, HTN and high BMI, for whom factors related to prognosis were Alb and AFP.

Cited by 7 publications

References 15 publications

Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis

Comparison of clinicopathologic characteristics among patients with HBV-positive, HCV-positive and Non-B Non-C hepatocellular carcinoma after hepatectomy: a systematic review and meta-analysis

Impact of Insulin Treatment on Prognosis of non-B non-C Hepatocellular Carcinoma After Hepatectomy

Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma

Contact Info

Product

Resources

About