“…Follow-up of these children for 2 years after the index wheezing episode showed that viral infection was not a risk for persistent wheezing. On the other hand, early sensitization particularly to mites and cockroach, at 2-4 years of age, and exposure to high levels of cockroach allergen in the home in the first 2 years of life were both strong and independent risk factors for persistence of wheezing [73]. Previous studies in Brazil showed that daycare centers and schools, in addition to homes, are sources of significant exposure to mite and cockroach allergens, which might contribute to sensitization [74 ,75].…”