Risk factors for pancreas and lung neuroendocrine neoplasms: a case–control study

Giraldi, Luca; Vecchioni, Alessia; Carioli, Greta; Bilotta, Mirna; Rosa, Stefano La; Imperatori, Andrea; Volante, Marco; Brizzi, Maria Pia; Inzani, Frediano; Petrone, Gianluigi; Schinzari, Giovanni; Bianchi, Antonio; Margaritora, Stefano; Alfieri, Sergio; Vecchia, Carlo La; Boccia, Stefania; Rindi, Guido

doi:10.1007/s12020-020-02464-5

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…Findings of Hassan and colleagues on higher prevalence of NEN in patients whose first‐degree relatives developed any cancer 38 suggest a possible hereditary basis. A link between NEN and cancer in general was also suggested by other studies, 39,40 supposing a shared cancer predisposition. However, the concurrence with other cancers might also be due to age, as NEN cases predominantly occur in higher age groups 41 .…”

Section: Discussionsupporting

confidence: 68%

Site‐specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany

Grundmann,

Voigtländer,

Hakimhashemi

et al. 2023

Cancer Medicine

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IntroductionNeuroendocrine neoplasms (NEN) are rare and heterogeneous epithelial tumors, occurring throughout the body. For gastroenteropancreatic (GEP)‐NEN, rising incidence rates were reported for the last decades, with underlying causes remaining largely unexplained. We evaluated NEN trends stratifying by their histologic subtypes.MethodsIncident cases of GEP‐NEN diagnosed between 2005 and 2019 were retrieved from the prospective, population‐based Bavarian Cancer Registry. GEP‐NEN were divided in their histologic subtypes, that is, neuroendocrine tumors (NET) G1, NET G2/G3, other NET versus small‐cell neuroendocrine carcinoma (NEC), large‐cell NEC, and other NEC. We calculated annual age‐standardized incidence rates (ASIRs) per 100,000 persons for the total of GEP‐NEN, NEN histologic subtypes, and tumor sites. We used an annual percentage change (APC) approach including a joinpoint analysis to investigate NEN incidence trends.ResultsASIR of GEP‐NEN rose from 2.2 in 2005 to 4.8 in 2019, characterized by a significant increase until 2012 (APC 2005–2012: 10.1%), followed by modest rise (APC 2012–2019: 1.5%). In the last decade, this increase was mainly driven by the rise of NET G1 and G2/G3, while incidence for NEC declined. Over the study period, ASIR increased significantly for all GEP‐sites except the colon. APCs were largest for the stomach, the appendix, the pancreas, and the rectum.ConclusionsThis study found a significant increase in the incidence of GEP‐NET. Though this development may partially be attributable to the increased use of advanced detection techniques and changes in NEN classification, further research should also focus on the identification of NEN risk factors.

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Section: Discussionsupporting

confidence: 68%

Site‐specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany

Grundmann,

Voigtländer,

Hakimhashemi

et al. 2023

Cancer Medicine

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“…This meta-analysis included a study with lung NETs with liver metastasis [ 26 ]. Existing studies have found that lung NETs may have distinct characteristics compared to GEP NETs [ 34 , 35 ]. To further assess this, sensitivity analysis was conducted excluding the study, which did not affect the major findings of this meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Carcinoid Crisis: A Systematic Review and Meta-Analysis

Suz

Reljic

et al. 2022

Cancers

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Background: Surgery is the only curative option for patients with neuroendocrine tumors (NET) and is also indicated for debulking of liver metastasis. Intraoperative carcinoid crisis (CC) is thought to be a potentially lethal complication. Though perioperative octreotide is often recommended for prevention, recent NET society guidelines raised concerns regarding limited data supporting its use. We sought to evaluate existing evidence characterizing CC and evaluating the efficacy of prophylactic octreotide. Methods: A systematic review was performed on studies including patients having surgery for well-differentiated NET and/or NET liver metastasis (2000–2021), and reporting data on the incidence, risk factors, or prognosis of CC, and/or use of prophylactic octreotide. Meta-analysis was performed using random-effects models. Results: Eight studies met inclusion criteria (n = 943 operations). The pooled incidence of CC was 19% (95% CI [0.06–0.36]). Liver metastasis (odds ratio 2.85 [1.49–5.47]) and gender (male 0.58 [0.34–0.99]) were the only significant risk factors. The occurrence of CC was associated with increased risk of major postoperative complications (2.12 [1.03–4.35]). The use of prophylactic octreotide was not associated with decreased risk of CC (0.73 [0.32–1.66]). Notably, there was no standard prophylactic octreotide strategy used. Conclusions: Intraoperative carcinoid crisis is a common complication occurring in up to 20% of patients with midgut NET and/or liver metastasis undergoing surgery. Prophylactic octreotide may not provide an efficient way to prevent this complication. Future studies should focus on prospective evaluation of well-defined prophylactic protocols using a standardized definition for CC.

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“…Jedoch sind eine positive Familienanamnese (erstgradige Verwandte mit Malignom jeglichen Typs), Rauchen und Alkoholabusus als Risikofaktoren sowohl mit funktionell aktiven als auch inaktiven PNET assoziiert 27 . Ebenso wird ein gehäuftes Auftreten bei Patienten mit Typ-II-Diabetes beobachtet 28 .…”

Section: Pankreatische Neuroendokrine Tumoren: Insulinom Und Gastrinomunclassified

Seltene chirurgische Tumoren im biliopankreatoduodenalen Bereich

Weniger¹,

Werner²

2022

Allgemein- und Viszeralchirurgie up2date

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Risk factors for pancreas and lung neuroendocrine neoplasms: a case–control study

Cited by 9 publications

References 34 publications

Site‐specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany

Site‐specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany

Perioperative Carcinoid Crisis: A Systematic Review and Meta-Analysis

Seltene chirurgische Tumoren im biliopankreatoduodenalen Bereich

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