Risk factors for nonwork-related adult-onset asthma and occupational asthma

Jeebhay, Mohamed F.; Ngajilo, Dorothy; Moual, Nicole Le

doi:10.1097/aci.0000000000000042

Cited by 21 publications

(27 citation statements)

References 82 publications

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“…OA and non-WRA are heterogeneous diseases with multiple phenotypes. Distinguishing phenotypes is important because it may help identify risk factors (17). As an example, adult-onset asthma is a phenotype of both OA and non-WRA that has been described using cluster analysis on sputum cells.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between Asthma in the Workplace and Non–Work-related Asthma

Malo¹,

Tarlo

Sastre

et al. 2015

Annals ATS

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The fifth Jack Pepys Workshop on Asthma in the Workplace focused on the similarities and differences of work-related asthma (WRA) and non-work-related asthma (non-WRA). WRA includes occupational asthma (OA) and work-exacerbated asthma (WEA). There are few biological differences in the mechanisms of sensitization to environmental and occupational allergens. Non-WRA and OA, when due to high-molecular-weight agents, are both IgE mediated; it is uncertain whether OA due to low-molecular-weight agents is also IgE mediated. Risk factors for OA include female sex, a history of upper airway symptoms, and a history of bronchial hyperresponsiveness. Atopy is a risk factor for OA due to high-molecular-weight agents, and exposure to cleaning agents is a risk factor for both OA and non-WRA. WEA is important among workers with preexisting asthma and may overlap with irritant-induced asthma, a type of OA. Induced sputum cytology can confirm airway inflammation, but specific inhalation challenge is the reference standard diagnostic test. Inhalation challenges are relatively safe, with the most severe reactions occurring with low-molecular-weight agents. Indirect health care costs account for about 50% of total asthma costs. Workers with poor asthma control (WRA or non-WRA) are less likely to be employed. Income loss is a major contributor to the indirect costs of WRA. Overall, asthma outcomes probably are worse for adult-onset than for childhood-onset asthma but better for OA than adult-onset non-WRA. Important aspects of management of OA are rapid and proper confirmation of the diagnosis and reduction of exposure to sensitizers or irritants at work and home.

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Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between Asthma in the Workplace and Non–Work-related Asthma

Malo¹,

Tarlo

Sastre

et al. 2015

Annals ATS

Self Cite

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“…The occurrence, intensity, and frequency of these symptoms vary over time, and are associated with variable expiratory airflow, airway wall thickening, and mucus development [7]. Adult- and childhood- onset asthma are quite different; the former is generally non-allergic with severer symptoms and rapid decline in pulmonary function [8]. Pollutants and irritants exposure, upper airway diseases, respiratory infections, female sex hormones, medications, obesity, and stressful life events have been associated with the adult-onset asthma [9].…”

Section: Introductionmentioning

confidence: 99%

Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study

et al. 2016

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BackgroundSjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population.MethodsWe conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS group included 4725 adult patients diagnosed between 2000 and 2006. Each patient was frequency-matched with four people without SS by sex, age and year of diagnosis. The occurrence and hazard ratio (HR) of asthma was monitored by the end of 2011.ResultsThe overall incidence density of asthma was 1.62-fold higher in the primary SS group than in the non-SS group (9.86 vs. 6.10 per 1000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.38 [95% confidence interval (CI) = 1.21–1.58]. Stratified analyses by sex, age group, and presence of comorbidity revealed that asthma incidences were all higher in the primary SS group than in the non-SS group, and the relative HRs of asthma associated with primary SS were significant in all subgroups.ConclusionPatients with primary SS are associated with an increased risk of developing asthma. We should pay more attention to this group of individuals and provide them with appropriate support.

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“…Data regarding sex shows that adult males are less likely than adult females to be admitted for a primary diagnosis of asthma holding other variables constant. The positive relationship between adult women and asthma incidence or prevalence has been consistently documented for many years and in various countries (Habib, Javer, & Buxton, ; Jeebhay, Ngajilo, & le Mousal, ; Neffen et al, ). This relationship contrasts with the development of asthma in children where males are more often affected than females.…”

Section: Discussionmentioning

confidence: 90%

Predicting admissions for adult asthma exacerbations in North Texas

Newcomb

2019

Public Health Nursing

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Objectives The purpose of this study was to provide a picture of asthma disparities and the contributions of social and environmental factors to asthma exacerbations in the north central region of Texas, where intense, rapid development is a feature of contemporary life. Design and Sample Cross‐sectional analysis of data associated with 66 hospitals in the 8 counties containing and surrounding the Dallas/Fort Worth metropolitan area. Census blocks containing adult asthma patients admitted to emergency departments (ED) or inpatient units for asthma exacerbations in 2014. Measures Data for secondary analysis were collected from the Dallas Fort Worth Hospital Council Foundation. Results Sex, family income, education, race, age of housing, speed, and traffic density on neighborhood roads affected asthma admissions. Proximity to urban drilling sites had only a small effect on admissions in this sample. Minorities were significantly more likely to obtain services in the ED than whites. Conclusions Attributes associated with poor and underserved patients predicted asthma exacerbations in the target region. These are vulnerable patients who can ill afford further erosion of health care insurance or additional environmental insults.

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Risk factors for nonwork-related adult-onset asthma and occupational asthma

Cited by 21 publications

References 82 publications

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between Asthma in the Workplace and Non–Work-related Asthma

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between Asthma in the Workplace and Non–Work-related Asthma

Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study

Predicting admissions for adult asthma exacerbations in North Texas

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