Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study

Abstract

BackgroundSjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population.MethodsWe conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS group included 4725 adult patients diagnosed between 2000 and 2006. Each patient was frequency-matched with four people without SS by sex, age and year of diagnosis. The occurrence and hazard ratio (HR) of asthma was monitored by the end of 2011.ResultsThe overall incidence density of asthma was 1.62-fold higher in the primary SS group than in the non-SS group (9.86 vs. 6.10 per 1000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.38 [95% confidence interval (CI) = 1.21–1.58]. Stratified analyses by sex, age group, and presence of comorbidity revealed that asthma incidences were all higher in the primary SS group than in the non-SS group, and the relative HRs of asthma associated with primary SS were significant in all subgroups.ConclusionPatients with primary SS are associated with an increased risk of developing asthma. We should pay more attention to this group of individuals and provide them with appropriate support.

Evaluation of Atopic Status in Patients With Primary Sjogren’s Syndrome

“…In our study, the rates of asthma and AR in patients with pSS were 6%, and 10%, respectively. Our rates were lower than the rates of atopic diseases reported in the previous studies (18,19). This result may arise from the number of study population or differences in the study methods.…”

Regulation of contact sensitivity in non‐obese diabetic (NOD) mice by innate immunity

“…NOD mice are genetically prone to immune dysregulation, which promotes multiorgan autoinflammation and allergy . Studies have shown that human subjects with autoimmune disorders are more susceptible to allergy . Additionally, the association of innate immunity with genetic makeup, such as C57BL/6 vs NOD, is not known, and there has not been a published study on the CHS response in NOD mice; to our knowledge, our current study is the first investigation in the literature.…”

“…26,27 Studies have shown that human subjects with autoimmune disorders are more susceptible to allergy. [28][29][30] Additionally, the association of innate immunity with genetic makeup, such as C57BL/6 vs NOD, is not known, and there has not been a published study on the CHS response in NOD mice; to our knowledge, our current study is the first investigation in the literature. Thus far, most CHS studies in the literature used mice on the C57BL/6 background.…”

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

“…In a cohort of 4,725 adults with SS matched with controls, the incidence of asthma was 1.62-fold higher in subjects with SS. 188 In a cohort of 3,013 women with SS, there was a 1.4-fold greater incidence of COPD than in matched controls. 189 In a smaller cohort study assessing COPD in 51 consecutive subjects with pSS, 41% had COPD based on Global Initiative of Chronic Obstructive Lung Disease (GOLD) criteria, including 30% of the nonsmokers with pSS.…”