Risk factors for mortality in critically ill patients with COVID-19: a multicenter retrospective case-control study

Gao, Jinghua; Zhong, Li; Wu, Ming; Ji, Jingjing; Liu, Zheying; Wang, Conglin; Xie, Qiuyou; Liu, Zhifeng

doi:10.1186/s12879-021-06300-7

Cited by 17 publications

(14 citation statements)

References 36 publications

(39 reference statements)

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“…Multivariable logistic regression model revealed PSI/PORT, A-DROP, MEWS, qSOFA scores, O 2 support, PLT, CRP and LDH as independent predictors for mortality. This may be the result of SARS-Cov-2 infection associated with hypoxia, thrombogenesis, inflammation and organ injury in concordance with previous studies [ 8 , 13 , 14 , 51 , 55 , 56 ].…”

Section: Discussionsupporting

confidence: 92%

Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia

Akıllı

Bilge

Guz

et al. 2022

JPM

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This is a retrospective and observational study on 1511 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 1511 patients, 879 male (58.17%) and 632 female (41.83%) with a mean age of 60.1 ± 14.7 were included in the study. Survivors and non-survivors groups were statistically compared with respect to survival, discharge, ICU admission and in-hospital death. Although gender was not statistically significant different between two groups, 80 (60.15%) of the patients who died were male. Mean age was 72.8 ± 11.8 in non-survivors vs. 59.9 ± 14.7 in survivors (p < 0.001). Overall in-hospital mortality was found to be 8.8% (133/1511 cases), and overall ICU admission was 10.85% (164/1511 cases). The PSI/PORT score of the non-survivors group was higher than that of the survivors group (144.38 ± 28.64 versus 67.17 ± 25.63, p < 0.001). The PSI/PORT yielding the highest performance was the best predictor for in-hospital mortality, since it incorporates the factors as advanced age and comorbidity (AUROC 0.971; % 95 CI 0.961–0.981). The use of A-DROP may also be preferred as an easier alternative to PSI/PORT, which is a time-consuming evaluation although it is more comprehensive.

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Section: Discussionsupporting

confidence: 92%

Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia

Akıllı

Bilge

Guz

et al. 2022

JPM

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“…(16) Characteristics such as age, sex, and having some comorbidities have been associated with greater susceptibility to infection and complications after infection by SARS-CoV-2. (7)(8)(9)(10)(11)17) In our data, the majority of those infected by SARS-CoV-2 who died were men, and they were older than the survivors, consistent other studies. (7,8) The identification of comorbidities has been key in the characterization of those who may be at risk of lower survival.…”

Section: Discussionsupporting

confidence: 91%

Characteristics, treatment, and nursing care of patients infected by Sars-CoV-2 hospitalized in intensive care units: multicenter study of colombian hospitals

Cortés

Paipa

Mojica

et al. 2022

invest. educ. enferm

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Objective. To describe the clinical characteristics, treatment, evolution, and nursing care of adult patients with severe acute respiratory distress syndrome who were positive for SARS-CoV-2 and hospitalized in intensive care units (ICUs) during the first peak of the pandemic in Colombia, 2020. Methods. Multicenter descriptive study of four high-complexity hospitals in Colombia, which included 473 consecutive adult patients admitted to intensive care units with a confirmed diagnosis of SARS CoV-2. Sociodemographic and clinical information - comorbidities, treatment and evolution - and nursing care provided were included. Results. Of the patients included, 43.7% died, 88.8% had pneumonia, and 60.2% developed respiratory distress syndrome. Most of those who died were men. Those who died had a median age of 68.4 years and a higher frequency of comorbidities (hypertension, cardiovascular disease, chronic obstructive pulmonary disease, and higher body mass index). They were admitted to the ICU with higher rate of dyspnea, lower oxygen saturation, and higher score of multiorgan failure. They also more often required mechanical ventilation and pronation therapy and were given more vasopressors and renal replacement therapy. Conclusion. People with severe acute respiratory distress syndrome due to COVID-19 who were hospitalized in the ICU had a high risk of death, especially older patients; males; those with cardiovascular, respiratory, and hypertension comorbidities; those who needed mechanical ventilation; and those with an elevated SOFA score. The nursing care of these critically ill patients focused on respiratory care and the prevention of associated complications.

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“…In our study, the cohort of mechanically ventilated patients with a CCI ≥ 3 had an approximately 5.38-fold higher mortality risk than the others. Gao et al reported that in-hospital death was associated with comorbidities (HR, 6.455, p = 0.007) and SOFA score on admission (HR 1.171, p = 0.033) in in-patients with severe COVID-19 [26]. In our study, a cohort of mechanically ventilated patients with a SOFA score of ≥3 had an approximately 5.04-fold higher mortality than the others.…”

Section: Discussionmentioning

confidence: 44%

Late Failure of High-Flow Nasal Cannula May Be Associated with High Mortality in COVID-19 Patients: A Multicenter Retrospective Study in the Republic of Korea

Baek

Seong

Lee

et al. 2021

JPM

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The aim of this study was to determine whether the late failure of high-flow nasal cannula (HFNC) is associated with mortality in patients with coronavirus disease 2019 (COVID-19). This multicenter study included seven university-affiliated hospitals in the Republic of Korea. We collected the data of patients hospitalized with COVID-19 between 10 February 2020 and 28 February 2021. Failure of HFNC was defined as the need for mechanical ventilation despite HFNC application. According to the time of intubation, HFNC failure was divided into early failure (within 48 h) and late failure (after 48 h). During the study period, 157 patients received HFNC and 133 were eligible. Among them, 70 received mechanical ventilation. The median time from HFNC initiation to intubation of the early failure group was 4.1 h (interquartile range [IQR]: 1.1–13.5 h), and that of the late failure group was 70.9 h (IQR: 54.4–145.4 h). Although the ratio of pulse oximetry/fraction of inspired oxygen (ROX index) within 24 h of HFNC initiation tended to be lower in the early failure group than in the late failure group, the ROX index before two hours of intubation was significantly lower in the late failure group (odds ratio [OR], 5.74 [IQR: 4.58–6.98] vs. 4.80 [IQR: 3.67–5.97], p = 0.040). The late failure of HFNC may be associated with high mortality in COVID-19 patients with acute respiratory failure.

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Risk factors for mortality in critically ill patients with COVID-19: a multicenter retrospective case-control study

Cited by 17 publications

References 36 publications

Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia

Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia

Characteristics, treatment, and nursing care of patients infected by Sars-CoV-2 hospitalized in intensive care units: multicenter study of colombian hospitals

Late Failure of High-Flow Nasal Cannula May Be Associated with High Mortality in COVID-19 Patients: A Multicenter Retrospective Study in the Republic of Korea

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