Comparison of Pneumonia Severity Indices, qCSI, 4C-Mortality Score and qSOFA in Predicting Mortality in Hospitalized Patients with COVID-19 Pneumonia

Abstract

This is a retrospective and observational study on 1511 patients with SARS-CoV-2, who were diagnosed with COVID-19 by real-time PCR testing and hospitalized due to COVID-19 pneumonia. 1511 patients, 879 male (58.17%) and 632 female (41.83%) with a mean age of 60.1 ± 14.7 were included in the study. Survivors and non-survivors groups were statistically compared with respect to survival, discharge, ICU admission and in-hospital death. Although gender was not statistically significant different between two groups, 80 (60.15%) of the patients who died were male. Mean age was 72.8 ± 11.8 in non-survivors vs. 59.9 ± 14.7 in survivors (p < 0.001). Overall in-hospital mortality was found to be 8.8% (133/1511 cases), and overall ICU admission was 10.85% (164/1511 cases). The PSI/PORT score of the non-survivors group was higher than that of the survivors group (144.38 ± 28.64 versus 67.17 ± 25.63, p < 0.001). The PSI/PORT yielding the highest performance was the best predictor for in-hospital mortality, since it incorporates the factors as advanced age and comorbidity (AUROC 0.971; % 95 CI 0.961–0.981). The use of A-DROP may also be preferred as an easier alternative to PSI/PORT, which is a time-consuming evaluation although it is more comprehensive.

Association of Different Risk Scores and 30-Day Mortality in Kidney Transplant Recipients with COVID-19

“…PSI/PORT previously yielded the best performance for in-hospital mortality amongst the general COVID-19 population compared to the qCSI, 4C Mortality Score and quick Sequential Organ Failure Assessment (SOFA) score [31]. This study consistently showed a significant association of PSI/PORT with 30-day post-discharge mortality, but the highest effect size was observed with the 4C Mortality Score.…”

“…All risk scores were calculated as recommended in the derivation and validation studies, using the appropriate patient-level data [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Elementary data about risk scores are shown in Supplementary Table S1.…”

“…The risk score ranges from 0 to 20 and divides patients into 4 risk groups based on the inhospital mortality [16]. Several external validation studies showed satisfactory performance of this risk score in assessing mortality risk [30,31].…”