Risk factors for mediastinal lymph node metastasis in non-small-cell lung cancer by PET/CT

Xu, Ze Qing; Xie, Liyang; Fan, Wei; Duan, Xiao Bei; Cheng, Mu-Hua

doi:10.1097/mnm.0000000000000077

Cited by 5 publications

(2 citation statements)

References 30 publications

(50 reference statements)

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“…Because the AUCs for SUV n/t and SUV max were not particularly informative, we hypothesized that tumor diameter may also influence the diagnostic accuracy because bigger or higher-stage tumors would have a greater possibility of LN metastasis. [22–24] We therefore assessed the diagnostic efficiency of SUV index , defined as SUV n/t multiplied by maximal tumor diameter on PET/CT. According to the results, SUV index (AUC 0.71, 95% CI 0.64–0.78) provided a better predictive index of mediastinal LN malignancy in lung cancer patients than SUV max or SUV n/t .…”

Section: Discussionmentioning

confidence: 99%

Ratio of lymph node to primary tumor SUVmax multiplied by maximal tumor diameter on positron emission tomography/integrated computed tomography may be a predictor of mediastinal lymph node malignancy in lung cancer

et al. 2016

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Positron emission tomography/integrated computed tomography (PET/CT) provides the most accurate imaging modality for preoperative lung cancer staging. However, the diagnostic accuracy of maximum standardized uptake value (SUVmax) for mediastinal (N2) lymph nodes (LN) is unclear. We compared SUVmax, the ratio of LN to primary tumor SUVmax (SUVn/t), and SUVn/t multiplied by maximal tumor diameter (SUVindex) in terms of their abilities to predict mediastinal LN malignancy.We retrospectively analyzed 170 mediastinal LN stations from 73 consecutive patients who underwent systemic LN resection and PET/CT within 27 days. The SUVmax of the primary tumors was >2.0 and the SUVmax of the mediastinal LN stations ranged from 2.0 to 7.0 on PET/CT. Receiver-operating characteristic curves (ROCs) of SUVmax, SUVn/t, and SUVindex were calculated separately and the areas under the curves (AUCs) were used to assess the abilities of the parameters to predict LN malignancy. The optimal cutoff values were calculated from each ROC curve and the diagnostic abilities were also compared. The diagnostic accuracies of the 3 methods were also assessed separately in smoking and nonsmoking patients.Twenty-eight LN stations were malignancy-positive and the remaining 142 were malignancy-negative. The AUCs for SUVindex, SUVn/t, and SUVmax were 0.709, 0.590, and 0.673, respectively, and the optimal cutoff values for SUVindex, SUVn/t, and SUVmax were 1.11, 0.34, and 3.6, respectively. The differences between SUVindex and SUVn/t were significant, but there was no significant difference between SUVindex and SUVmax. There were no significant differences between smokers and nonsmokers in the AUCs for any of the methods for predicting LN malignancy (P values >0.05).SUVindex may be a predictor of mediastinal LN malignancy in lung cancer patients.

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Section: Discussionmentioning

confidence: 99%

Ratio of lymph node to primary tumor SUVmax multiplied by maximal tumor diameter on positron emission tomography/integrated computed tomography may be a predictor of mediastinal lymph node malignancy in lung cancer

et al. 2016

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“…Several studies have been undertaken to investigate the relationship between standard uptake value (SUV) of primary lung cancer lesions and node involvement, and the results showed that SUV max of the primary tumor might be an independent predictor of regional lymph node metastasis in patients with NSCLC. CT is widely used as the standard of care procedure used routinely for assessing NSCLC, and the vast majority of lung cancer patients undergo only chest CT as their diagnostic procedure.…”

Section: Introductionmentioning

confidence: 99%

Prediction of pathological nodal involvement by CT‐based Radiomic features of the primary tumor in patients with clinically node‐negative peripheral lung adenocarcinomas

et al. 2018

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Independent risk factors for lymph node metastasis in 2623 patients with Non–Small cell lung cancer

et al. 2020

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Risk factors for mediastinal lymph node metastasis in non-small-cell lung cancer by PET/CT

Abstract: The mediastinal lymph node metastasis ratio was correlated with SUV(max), size, and differentiation in primary lung lesions. SUV(max) was the only independent predictor of lymph node metastasis in NSCLC. Video Abstract: http://links.lww.com/NMC/A22.

Cited by 5 publications

References 30 publications

Ratio of lymph node to primary tumor SUVmax multiplied by maximal tumor diameter on positron emission tomography/integrated computed tomography may be a predictor of mediastinal lymph node malignancy in lung cancer

Ratio of lymph node to primary tumor SUVmax multiplied by maximal tumor diameter on positron emission tomography/integrated computed tomography may be a predictor of mediastinal lymph node malignancy in lung cancer

Prediction of pathological nodal involvement by CT‐based Radiomic features of the primary tumor in patients with clinically node‐negative peripheral lung adenocarcinomas

Independent risk factors for lymph node metastasis in 2623 patients with Non–Small cell lung cancer

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