Risk Factors for Meconium Aspiration and Mas (Meconium Aspiration Syndrome) in Neonates Born Through Meconium Stained Amniotic Fluid (Msaf) in a Tertiary Care Centre in Malabar (Kerala)

Chandran, Jyoti Ramesh; N, Uma Devi; Rajeshwary, U

doi:10.14260/jemds/1647

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…[15][16][17] While other studies done by Chandran et al, and Vivian -Taylor et al, proposed that post datism (>40 wks) contributed to MAS. 18,19 In present study, there were 12 ( [22][23][24] But in our study, there were no association between MAS and the route of delivery.…”

Section: Birth Asphyxiacontrasting

confidence: 57%

Meconium aspiration syndrome and neonatal outcome: a hospital based study

Saranappa

Devaraj

Nithya

2019

Int J Contemp Pediatr

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Background: The incidence of meconium stained amniotic fluid is 8-20% among all deliveries. The Aspiration of meconium into the airway results in various short term and long term morbidities and mortality. Timely management of these neonates with meconium in amniotic fluid may prevent Meconium aspiration syndrome.Methods: This prospective cohort study was conducted at Kempegowda Institute of Medical Sciences, Bangalore. All live Term neonates born between December 2016 and July 2018 with meconium in amniotic fluid were enrolled in the study. Details of the neonate was entered in the pre-designed Proforma. The objective of this study the outcome of MAS neonates and find factors associated with Meconium aspiration syndrome when compared with Meconium stained amniotic fluid neonates as a whole. These associated factors were presented as Odds Ratio (OR) and 95% Confidence Interval. Chi-square test was done where applicable and a p-value <0.05 was taken as significant.Results: Meconium aspiration syndrome was seen in 79 out of the 188 neonates born with meconium stained amniotic fluid.Conclusions: The morbidity and mortality in a neonate with Meconium stained amniotic fluid (MSAF) to develop meconium aspiration syndrome (MAS) can be avoided with timely antenatal care. Meconium-stained babies should be aggressively managed to prevent complications like perinatal asphyxia and respiratory failure which may lead to the mortality. Those neonates with risk for adverse outcome should be managed with special focus on respiratory care with use of assisted ventilation and inhaled nitric oxide and extracorporeal membrane oxygenation, where available.

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Section: Birth Asphyxiacontrasting

confidence: 57%

Meconium aspiration syndrome and neonatal outcome: a hospital based study

Saranappa

Devaraj

Nithya

2019

Int J Contemp Pediatr

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“…21,23 Mortality was 13.82% which is exactly similar to study of Jyoti et al who also reported mortality of 13.8% in MAS neonates. 24 Narang et al reported lower neonatal mortality of 7.7% whereas Gupta et al reported higher neonatal mortality of 22.2% in MAS cases. 5,6 Previous studies have shown a wide range (5-40%) in the mortality among infants with MAS, which is well correlated with this study.…”

Section: Resultsmentioning

confidence: 96%

“…5,20,21 Similar to present study, Louis et al and Jyoti et al observed higher incidence of morbidity and mortality in MAS neonates having lower APGAR score at 5 minutes of birth. 23,24 The incidence of thick meconium stained liquor was 54.3% which is significantly associated with morbidity and mortality in MAS neonates. This is in consistence with Hanoudi et al and Yong et al 16,25 In the present study, onset of respiratory distress in all the cases was since birth and 3 cases had no spontaneous respiration at birth which is similar to Louis et al according to him median age at onset of respiratory distress was 0 hour.…”

Section: Resultsmentioning

confidence: 99%

Meconium aspiration syndrome: clinical profile, risk factors and outcome in central India

Kamble

Jain

2018

Int J Contemp Pediatr

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Background: Meconium aspiration syndrome (MAS) is a life-threatening respiratory disease affecting some neonates born through meconium-stained amniotic fluid (MSAF). MSAF complicates delivery in approximately 8% to 25% of live births, of which nearly 5% of the neonates born through MSAF develop MAS. The present study was undertaken to find out the prevalence of MSAF and MAS and to study the etiology, risk factors, clinical profile and outcome of MAS.Methods: By purposive sampling technique, all newborns, fulfilling the inclusion criteria during one year of study period were enrolled in this hospital based cross-sectional observational study. Risk factors and clinical profile were compared between those who died and survived.Results: Out of 8765 deliveries in hospital 1220 neonates were born with MSAF of which 94 neonates had MAS. Thereby, incidence of MSAF was 13.9% and incidence of MAS out of MSAF was 7.7 %. Of the 94 neonates who had MAS 13.82% died. Almost 3/4th of the MAS neonates were term and AGA. MAS were more common in primigravida mother (68%) and LSCS deliveries (53.2%). Of the total MAS 54.2% had thick meconium in whom mortality was 92.3%. The mortality in MAS cases was significant in low 5-minute APGAR score and non-vigorous baby.Conclusions: Since MSAF is associated with higher morbidity and mortality, if the knowledge of risk factors is known to health care personnel then timely referral or intervention can help in decreasing MAS and its complications.

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“… 11 Studies conducted in Nepal have revealed the prevalence of MSAF about 6.5%-14.6%, 8 , 9 , 12 among all live deliveries, the prevalence of MAS among MSAF about 6.6% to 8.6%, 8 , 12 and neonatal mortality from MAS about 5.4% to 11.3%. 8 , 9 , 12 The study conducted in India found the prevalence of MAS among MSAF as 7.7% to 21.5%, 4 - 6 and mortality among MAS as high as 13.8%. 4 - 6 The most common complication of MAS is Respiratory distress and other morbidities were convulsions, sepsis, shock, hypoxic-ischemic encephalopathy, hyperbilirubinemia and hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

“… 8 , 9 , 12 The study conducted in India found the prevalence of MAS among MSAF as 7.7% to 21.5%, 4 - 6 and mortality among MAS as high as 13.8%. 4 - 6 The most common complication of MAS is Respiratory distress and other morbidities were convulsions, sepsis, shock, hypoxic-ischemic encephalopathy, hyperbilirubinemia and hypoglycemia. 13 …”

Section: Discussionmentioning

confidence: 99%

Neonates Born Through Meconium-stained Amniotic Fluid among Deliveries in a Tertiary Care Centre: A Descriptive Cross-sectional Study

2022

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Introduction: The mortality and morbidity of meconium aspiration syndrome in neonates born with meconium-stained amniotic fluid in developing countries are still high. In Nepal, few studies have estimated the prevalence of meconium-stained amniotic fluid among newborns. The study aimed to find out the prevalence of neonates born through meconium-stained amniotic fluid among deliveries in a tertiary care centre. Methods: This descriptive cross-sectional study was conducted among neonates born in a tertiary care centre from November 2021 to March 2022. Neonates born during the study period with meconium-stained amniotic fluid were studied. Ethical approval was obtained from the Institutional Review Committee. Convenience sampling method was used. With permission from the Department of the Neonatal Intensive Care Unit, the data were collected and entered in a Microsoft Excel sheet. Point estimate and 95% Confidence Interval were calculated. Results: Among 576 neonates, the prevalence of neonates born through meconium-stained amniotic fluid was 77 (13.37%) (10.59-16.15, 95% Confidence Interval). Conclusions: The prevalence of neonates born through meconium-stained amniotic fluid was found to be similar to other studies done in similar settings.

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Risk Factors for Meconium Aspiration and Mas (Meconium Aspiration Syndrome) in Neonates Born Through Meconium Stained Amniotic Fluid (Msaf) in a Tertiary Care Centre in Malabar (Kerala)

Abstract: U, "Risk factors for meconium aspiration and mas (meconium aspiration syndrome) in neonates born through meconium stained amniotic fluid (MSAF) in a tertiary care centre in Malabar (Kerala)".

Cited by 4 publications

References 8 publications

Meconium aspiration syndrome and neonatal outcome: a hospital based study

Meconium aspiration syndrome and neonatal outcome: a hospital based study

Meconium aspiration syndrome: clinical profile, risk factors and outcome in central India

Neonates Born Through Meconium-stained Amniotic Fluid among Deliveries in a Tertiary Care Centre: A Descriptive Cross-sectional Study

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