Meconium aspiration syndrome: clinical profile, risk factors and outcome in central India

Kamble, Milind B.; Jain, Poonam

doi:10.18203/2349-3291.ijcp20185198

Cited by 8 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5] Almost two-thirds (61%) of births in our sample were through caesarean sections, but mode of delivery was not found to be a risk factor for disease severity. Our finding is similar to that of Khazardoost et al, [14] although other researchers have noted caesarean section as a risk factor for severe disease [4,6,11,13] or that it could even reduce the risk of MAS. [15] Our study did not evaluate indications for caesarean section.…”

Section: Discussionsupporting

confidence: 92%

“…Advanced gestational age (>41 weeks) was not found to be risk factor for disease severity in our study, although other studies have found this to be a risk factor for severe MAS. [6,13,15,19] Our finding may be due to the small number of neonates born after 41 weeks in our sample. Preventing gestation to progress beyond 41 weeks has been shown to decrease the risk of acquiring MAS in developed countries.…”

Section: Discussionmentioning

confidence: 69%

“…Neonates born in tertiary centres had a higher risk of acquiring MAS owing to high-risk pregnancies being delivered at these centres. [4] Results on mode of delivery as a risk factor for MAS vary, with some studies showing an increased risk, [4,13] some reporting no risk, [14] and others showing reduced risk of acquiring MAS with caesarean section. [15] The higher risk could be related to the fetus already being compromised.…”

Section: Researchmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology and risk factors for acquiring and predicting disease severity in meconium aspiration syndrome

Singh

Adhikiri²,

Tinarwo³

et al. 2022

S Afr J Child Health

View full text Add to dashboard Cite

Background. Meconium aspiration syndrome (MAS) occurs in approximately 5% of babies born through meconium-stained amniotic fluid. Risk factors associated with severity of MAS in neonates from developing countries has been infrequently described. Objective. To identify incidence and risk factors associated with the severity of MAS in a lower middle-income country. Method. A retrospective descriptive analysis was conducted on records of neonates diagnosed with MAS at four regional hospitals in the eThekwini district of KwaZulu-Natal, South Africa, between 1 January 2015 and 31 December 2017. Results. A total of 187 neonates had been diagnosed with MAS, of whom 157 survived. The overall incidence of MAS was 2 per 1 000 live births. All the neonates were born through thick meconium. The majority (n=119, 63.6%) of patients were male. Asphyxia was documented in 97 cases (51.9%) and was significantly associated with severe disease (p<0.001). Seizures were noted in 91patients (48.7%), of which 86 (94.5%) occurred in neonates with asphyxia. A quarter of the sample (n=47, 25%) were outborn, with severe disease associated significantly with this group (p=0.025). Multiple logistic regression showed that the occurrence of seizures was significantly associated with severe MAS, (adjusted odds ratio = 23.7, 95% confidence interval 7.58 - 97.7; p<0.001). Conclusion. Neonates born through thick meconium, with moderate to severe asphyxia that is associated with seizures are at increased risk of developing severe MAS. Close monitoring of labour in the intrapartum period, early recognition of fetal distress and timely obstetric intervention are crucial to prevent asphyxia.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 69%

Section: Researchmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology and risk factors for acquiring and predicting disease severity in meconium aspiration syndrome

Singh

Adhikiri²,

Tinarwo³

et al. 2022

S Afr J Child Health

View full text Add to dashboard Cite

show abstract

“…Kamble et al conducted a crosssectional observational study which was hospital based, in which the frequency of MSAF was 13.9% and occurrence of MAS out of MSAF was 7.7%. 5 Shilpasri et al found that the incidence of meconium aspiration syndrome was 11%. 6 Rajnish Chaudhary et al concluded that MAS diagnosed most frequently in neonates with fetal distress (42.17%) and in mothers having history of PIH (12.05%).…”

Section: Discussionmentioning

confidence: 99%

Immediate outcome of meconium aspiration syndrome with respect to neonatal maturity and birth weight

Ahmed

Bavalatti

Thobbi

2023

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: About 13% of live births result in MSAF, and as gestational age at birth increases, this percentage increases as well. About 5% of babies born with MSAF develop MAS (meconium aspiration syndrome). The mortality rate from MAS is still as high as 3-5 percent, even with modern NICU care. Methods: This study was a hospital-based a prospective observational study over an 18-months period, and all babies were admitted to the NICU who satisfied the MAS criteria were added in the study. The babies were monitored for their immediate outcome. Results: MAS was more prevalent among mother who had a history of pregnancy-induced hypertension and in neonates who were in fetal distress. With a mean gestational age of 38-40 weeks and a mean birth weight of 2.76 kg, it is more common in term newborns and babies born by caesarean section. The most frequent cause of death, birth asphyxia, which accounted for 30.7% of cases of MAS, was most frequently associated with neonates who were depressed at birth. Conclusions: Term and post-term neonates with weight >2.5 kg at birth are frequently associated with MAS. When meconium was present below the vocal cords, a low APGAR score at 1 minute and thick meconium were associated with a higher mortality rate. Non-vigorous babies require early and effective management, and early assisted ventilator support may be necessary when there is evidence of thick meconium. Asphyxiated babies should be carefully monitored. effective intrapartum suctioning, neonatal care, an accurate diagnosis and prompt treatment can significantly lessen the complications, morbidity and mortality in meconium aspiration syndrome.

show abstract

“…In addition, RD morbidity in low resource settings seems to be greater compared to data of high-income countries [9]. As epidemiological trends show an increasing rate of RD in full-term newborns [10,11] we designed this study with the primary objective to assess and describe clinical aspects, causes and management of RD in full and post-term neonates in a tertiary facility in Yaoundé.…”

Section: Introductionmentioning

confidence: 99%

Respiratory distress in Full and Post term neonates: Prevalence, Etiologies and Outcomes in a Tertiary Health Center in Yaoundé

Kue

Nanfack²,

NLEND³

2020

Preprint

View full text Add to dashboard Cite

Introduction Respiratory distress (RD) is a common condition for admission of newborns in neonatal care unit (NCU), in both preterm and full-term neonates. Our objective was to describe the clinical features, causes and treatment of RD in full term neonates in a tertiary health center in Yaoundé, the Essos Hospital Centre (EHC). Patients and Method We conducted a cross sectional retrospective study. Full term neonates with RD at EHC from January 2017 to December 2018 were included, assuming clinical signs of RD prior to 48 hours following admission. Factors evaluated: incidence of RD, main etiologies, short term outcomes and risk factors for severity. Data were collected using a chart, then analyzed using software Stata Version 13.Results 186 full term neonates out of 2312 newborn babies admitted in NCU, met the inclusion criteria giving a prevalence rate of RD of 8%. Sex ratio of 2.15 was favoring males; median age at admission was 7.25 hours and 89.2 % were born at a median gestational age of 38 weeks. Clinical signs of RD were dominated by signs of respiratory control with a Silverman score above 4/10 in 64%. The most common etiologies were neonatal infection / pneumonia (45.9%), followed by transient tachypnea. Clinical management was performed using nasal cannula oxygen and antibiotics. Perinatal asphyxia, cyanosis and caesarian section were found to be associated with severe RD in this setting. Mortality rate was 10.4%.Conclusion RD in full term neonates is common in this setting, with neonatal infection as preeminent etiology; the mortality rate is high and the management still inappropriate.

show abstract

Meconium aspiration syndrome: clinical profile, risk factors and outcome in central India

Cited by 8 publications

References 12 publications

Epidemiology and risk factors for acquiring and predicting disease severity in meconium aspiration syndrome

Epidemiology and risk factors for acquiring and predicting disease severity in meconium aspiration syndrome

Immediate outcome of meconium aspiration syndrome with respect to neonatal maturity and birth weight

Respiratory distress in Full and Post term neonates: Prevalence, Etiologies and Outcomes in a Tertiary Health Center in Yaoundé

Contact Info

Product

Resources

About