Risk factors for incomplete excision of squamous cell carcinomas

Bogdanov-Berezovsky, Alex; Cohen, Arnon D.; Glesinger, Ronen; Cagnano, Emanuela; Rosenberg, Lior

doi:10.1080/09546630500424649

Cited by 31 publications

(33 citation statements)

References 22 publications

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“…Still, well-differentiated SCCs are also able to metastasize, which underscores that one should not only rely on 1 histological feature regarding prognosis. 19 Previous studies on incomplete SCC excision have not demonstrated a relation between differentiation and reexcision rates, 20,21 or omitted to examine this association. 22 The results of our study indicate poor differentiation was a significant risk factor for incomplete surgical excision.…”

Section: Discussionmentioning

confidence: 97%

The Effect of Differentiation Grade of Cutaneous Squamous Cell Carcinoma on Excision Margins, Local Recurrence, Metastasis, and Patient Survival

Brinkman¹,

Hajder²,

Holt³

et al. 2015

Annals of Plastic Surgery

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Section: Discussionmentioning

confidence: 97%

The Effect of Differentiation Grade of Cutaneous Squamous Cell Carcinoma on Excision Margins, Local Recurrence, Metastasis, and Patient Survival

Brinkman¹,

Hajder²,

Holt³

et al. 2015

Annals of Plastic Surgery

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“…27 In a separate internal audit of BCC and SCC excised by dermatologists (excluding MMS) in New Zealand, the incomplete excision rate was 0.56% (9/1615), which is the lowest thus reported. 27 10 Plastic surgeons and registrars, tertiary referral centre 480 6.3 22 Dermatologists, outpatient surgery based in tertiary hospital 117 5.2 23 Head and neck squamous cell carcinoma, maxillofacial unit in two hospitals 227 7.0 24 Tertiary referral centre 63 15.9 25 Plastic surgeons in a university medical centre 369 6.8…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the treatment of non‐melanoma skin cancers by surgical excision

2009

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A retrospective study of all non-melanoma skin cancers excised by two dermatologists at a private practice in 2004 (excluding Mohs microscopic surgery cases) was conducted. Two hundred and forty-one patients were treated, with a total of 453 tumours excised. The overall incomplete excision rate was 2.2% (10/453). For basal cell cancers, the incomplete excision rate was 1.54% (5/324) and for squamous cell cancers including Bowen's disease the incomplete excision rate was 3.9% (5/129). The majority of repairs were primary closures (82.6%). Although a significant proportion of the tumours were from the head and neck region (45.9%), this study demonstrated that careful patient selection, experience of the surgeon and adherence to recommended excision margins can achieve a favourable incomplete excision rate.

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“…560 The other studies assessing incomplete excision were retrospective reviews and in those in which the excision margin was specified, margins between 3 mm and 6 mm were used. 546,553,555,559,562 The highest percentage of incompletely excised tumours were observed after excision of periorbital lesions with a 5-mm margin, with 25% being incompletely excised (95% CI 15.3% to 37.0%). 546 None of the included studies reported SCC specific QoL, cosmetic appearance or adverse event data.…”

Section: Combined Griffiths 2002 544mentioning

confidence: 99%

“…543,548 Incompleteness of surgical excision was reported in 11 studies (comprising 2343 excisions). Overall, the pooled average estimate of incomplete excisions was 8.8% (95% CI 5.3% to 13.0%; I 2 = 89%) 541,544,546,550,553,555,[559][560][561][562][563] (see Appendix 6 and Figure 35). Definitions of incomplete excision within the studies were not consistent.…”

Section: Combined Griffiths 2002 544mentioning

confidence: 99%

“…These were based on the presence of tumour cells at the surgical margin, 553,559,561,562 the presence of residual tumour at or within 1 mm of the lateral or deep margins of the excised specimen, 555 tumour within one microscopic high-power field (0.5 mm) 560 and the presence of tumour at or 'close to' the margin of the resected specimen. 563 There was variation in the excision margins employed.…”

Section: Combined Griffiths 2002 544mentioning

confidence: 99%

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A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

Kim

Batchelor

Bath‐Hextall

et al. 2016

Programme Grants Appl Res

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Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10177. The contractual start date was in September 2008. The final report began editorial review in April 2014 and was accepted for publication in April 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, CCF, NETSCC, PGfAR or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, ...

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Risk factors for incomplete excision of squamous cell carcinomas

Cited by 31 publications

References 22 publications

The Effect of Differentiation Grade of Cutaneous Squamous Cell Carcinoma on Excision Margins, Local Recurrence, Metastasis, and Patient Survival

The Effect of Differentiation Grade of Cutaneous Squamous Cell Carcinoma on Excision Margins, Local Recurrence, Metastasis, and Patient Survival

Evaluation of the treatment of non‐melanoma skin cancers by surgical excision

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

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