Risk factors for incident dementia after stroke and transient ischemic attack

Abstract

Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment.

Risk factors associated with post-stroke dementia: a systematic review and meta-analysis

“…Fifteen abstracts were excluded because the result no associated with poststroke dementia, thirteen articles cannot calculate the data for the relative risks of dementia in stroke patients. The remaining 8 articles 20,21,23,[26][27][28][29][30] selected by the selection criteria can be calculated to identify the relative risks of dementia, as shown in Figure 1. Table 1 shows the demographic details of hospital-based and population-based studies of dementia after stroke such as study design, and methods used to measure dementia in all the publications that were relevant to the eligible hospital-based and population-based studies of dementia after stroke.…”

“…First, demographics and clinical characteristics of patients which showed increasing age associated with an increased risk of poststroke dementia in most studies. 16,[18][19][20][21]23,25,32 Adding demographics factors showed that the risk of incident dementia elevated in relation to older age especially > 80 years (RR 4.66, 95%CI; 2.36 to 9.22) and age 70 to 79 years (RR 2.68, 95%CI; 1.52 to 4.74) versus age 60 to 69 years. 28 33 Previous mental decline was the correlation of dementia in logistic regression analysis (OR 1.20, 95%CI; 1.10 to 1.40).…”

“…31 Cognitive impairment before stroke risk of dementia after stroke showed that cognitive impairment before stroke was associated with potential covariates and diagnosis of poststroke dementia in the Helsinki Stroke Ageing Memory study cohort (OR 5.76, 95%CI; 2.84 to 11.70). 10 Second, vascular risk factors such as diabetes mellitus were associated with an increased risk of dementia in stroke patients 10,11,16,[20][21][22]24,32 who had history of diabetes mellitus associated with incident demen- tia (OR 1.90, 95%CI; 1.15 to 3.16). 20 Hypertension was independently associated with the risk of post-stroke dementia.…”

“…10 Second, vascular risk factors such as diabetes mellitus were associated with an increased risk of dementia in stroke patients 10,11,16,[20][21][22]24,32 who had history of diabetes mellitus associated with incident demen- tia (OR 1.90, 95%CI; 1.15 to 3.16). 20 Hypertension was independently associated with the risk of post-stroke dementia. Multivariate analysis of predictors of poststroke dementia showed that hypertension was associated with an increased prevalence of poststroke dementia (OR 1.38, 95%CI; 1.05 to 1.82).…”

“…3 This may result from stroke and Alzheimer's disease or from other factors 16,17 such as aging, low education level, diabetes mellitus, atrial fibrillation, myocardial infarction, hypertension, medial temporal lope atrophy and white matter changes. 10,11,16,[18][19][20][21][22][23][24][25] Currently, dementia is considered untreatable, and there are many factors that cause dementia. The previous study was unable to identify the factors that affect directly.…”