Risk factors for idiopathic orbital inflammation: a case-control study

Abstract

Objective To identify risk factors involved in the development of idiopathic orbital inflammation (IOI). Methods Caseecontrol study of 69 adults who had had a first episode of IOI and 296 adult controls with rhegmatogenous retinal detachment (RD) selected from three orbital centres in The Netherlands between 2000 and 2006. Participants filled out a questionnaire on demographic factors, medical history, health status and exposures for the 2 years prior to disease presentation. In addition, women were questioned about previous or current pregnancies and their hormonal status. ORs and accompanying 95% CIs for IOI in relation to potential risk factors such as body mass index (BMI), bisphosphonates and autoimmune disease were estimated. ORs were adjusted for age, sex, socio-economic status, smoking and blunt orbital trauma using logistic regression. Analyses were carried out both with and without multiple imputation of missing values. Results The risk of IOI was increased in participants who had a higher BMI (third vs first tertile: OR, 2.88; 95% CI 1.32 to 6.32) and in participants who used bisphosphonates (OR 8.68; 95% CI 1.16 to 65.0). The risk was decreased in participants with a higher socioeconomic status (third vs first tertile: OR 0.38; 95% CI 0.17 to 0.84) and in women who were older at first childbirth (third vs first tertile: OR 0.14; 95% CI 0.03 to 0.64). An almost significant association was found for IOI and autoimmune disease (OR 2.56; 95% CI 0.93 to 7.05). Conclusions IOI is associated with lower socioeconomic status, higher BMI and use of oral bisphosphonates. In women, IOI is also associated with younger age at first childbirth.

A 55‐year‐old woman with orbital inflammation

“…A recent case–control study of 69 patients presenting with their first episode of idiopathic orbital inflammation between 2000 and 2006 and compared to 296 adult controls with retinal detachment found an increased risk of orbital inflammation in users of an oral bisphosphonate (odds ratio 8.68, 95% confidence interval 1.16–65) (34), a finding that further adds support to this association.…”

Efficient treatment of resistant orbital pseudotumor with cyber-knife: Case Series and short review of literature

“…[16] Additionally, there may be some risk factors precipitating the disease recurrence in the presence of infection [17,18] and autoimmune disease. [19,20] Also, obesity, pregnancy, and bisphosphonate use may also cause disease recurrence. [20] In our case series, a patient showed disease recurrence despite the lack of presented risk factors except onset of young age.…”

“…[19,20] Also, obesity, pregnancy, and bisphosphonate use may also cause disease recurrence. [20] In our case series, a patient showed disease recurrence despite the lack of presented risk factors except onset of young age.…”

Multiple deprivation, vision loss, and ophthalmic disease in adults: global perspectives

“…66; 83; 156; 179; 182; 214; 288 226 Studies investigating the impact of deprivation on ocular surface and corneal disease include the following areas: the prevalence and treatment of trichiasis 1; 6; 114; 131; 247;57; 164; 166; 284 the prevalence of blinding corneal disease 48; 145; 228; 240; 243; 281; 300 outcomes after laser refractive surgery 43 and outcome after corneal transplantation. 39; 47; 234 In terms of intraocular conditions, areas of study included the impact of deprivation on: the prevalence of uveitis 14 ; the characteristics of patient with retinal dystrophy, 11 and the onset and severity of rhegmatogenous retinal detachment. 173; 213 IX Conclusions…”