Risk factors for HTLV‐1, acute kidney injury, and urinary tract infection among aboriginal adults with end stage kidney disease in central Australia

Talukder, Mohammad Radwanur Rahman; Clauss, Cornelia Silke; Sajiv, Cherian; Woodman, Richard; Einsiedel, Lloyd

doi:10.1002/jmv.27163

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…Regarding the renal affection, it has been recently hypothesized that the chronic inflammatory state associated with HTLV-1 infection may be involved in its development ( 22 ). However, this has been reported specifically among the adult Australian aboriginal population with very high PVL.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

et al. 2021

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Human T-lymphotropic virus type 1 (HTLV-1) is a neglected retrovirus distributed worldwide and the ethiological agent of several pathologies, such as adult T-cell leukemia/lymphoma (ATLL), a chronic myelopathy known as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). HTLV-1 presents tropism for CD4+ T cells and induces deregulation of the cytokine profile. IDH is a severe, chronic superinfected eczema generally associated with Staphylococcus aureus and/or Streptococcus beta haemolyticus infection that responds partially to antibiotic therapy but prompt recurrence develops upon treatment withdrawal. IDH could be a risk factor for progression toward both HAM/TSP and ATLL and, similarly to other diseases associated with HTLV-1, it is sub-diagnosed particularly in non-endemic areas. Here, we present a case of IDH in a young boy living in Buenos Aires with symptoms since 2010, at the age of 5. HTLV-1 infection was suspected and confirmed in 2016. The patient exhibited chronic dermatosis with exudative eruption involving mainly the scalp, retroauricular regions, neck and abdomen. Clinical evaluations, routine laboratory tests, full blood count, and HTLV-1 diagnosis for this case are included.

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Section: Discussionmentioning

confidence: 99%

Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

et al. 2021

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“…Повышенный риск инфекций мочеполовых путей у мужчин выявлен при высокой вирусной нагрузке HTLV-1 [43]. Кроме того, в этом случае высока вероятность развития хронической болезни почек [42].…”

Section: заболевания мочеполовой системыunclassified

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

Радыгина,

Мочалова

2024

Microbiology Independent Research Journal (MIR Journal)

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ВВЕДЕНИЕ: Т-лимфотропный вирус типа 1 человека (HTLV-1) относится к семейству Retroviridae (род Deltaretrovirus) и напрямую участвует в канцерогенезе. Геном HTLV-1 представлен плюс-цепью РНК, которая транскрибируется в провирусную ДНК, а затем встраивается в геном клетки хозяина. После интеграции HTLV-1 присутствует в клетке в форме провируса. Как и для вируса иммунодефицита человека, основными мишенями HTLV-1 служат CD4+ T-лифоциты. Вирус передается через биологические жидкости организма: сперму, кровь и грудное молоко, – то есть половым путем, при гемотрансфузии и грудном вскармливании. Что касается эпидемиологии HTLV-1, то она до сих пор остается загадкой: кластеры с высокой эндемичностью часто расположены вблизи районов, где вирус практически отсутствует. ЦЕЛЬ: Проанализировать клиническую картину, диагностику и лечение заболеваний, вызванных HTLV-1. МЕТОДЫ: Проведен поиск литературы в базах PubMed, elibrary.ru и cyberleninka.ru по ключевым словам: «HTLV-1»+«diseases», «HTLV-1»+«diagnosis», «HTLV-1»+«epidemiology», «HTLV-1»+«treatment», «HTLV-1»+«Russia»; «HTLV-1»+«болезни», «HTLV-1»+«диагностика», «HTLV-1»+«эпидемиология», «HTLV-1»+«лечение», «HTLV-1»+«Россия». Основной поиск проведен за 2020–2024 гг. РЕЗУЛЬТАТЫ: С HTLV-1 связаны такие заболевания, как Т-клеточный лейкоз/лимфома и миелопатия/тропический спастический парапарез. При HTLV-1-инфекции регистрируют патологии большинства систем органов. В связи с тем, что ассоциированные с HTLV-1 заболевания чаще всего протекают бессимптомно, этиологическую диагностику проводят уже на стадии развития патологии или при скрининге крови доноров на патогены. ЗАКЛЮЧЕНИЕ: В обзоре рассмотрены вопросы клинических проявлений и течения заболеваний, вызванных HTLV-1, их диагностики и лечения. Несколько настораживает отсутствие серьезных популяционных исследований по распространенности этого вируса – фактически, диагностика на HTLV-1 предусмотрена только у доноров и у беременных. До сих пор этот вирус считается эндемичным для ряда территорий (Африка, Австралия, Ближний Восток, Япония и др.) и некоторых коренных народов, но, учитывая беспрецедентные миграционные потоки и международные связи в современном мире, мы считаем важным привлечь к нему внимание как эпидемиологов, так и клиницистов.

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“…As a widespread treatment method for ESRD patients, dialysis removes excess water, soluble substances, and toxins from the blood, performing a function similar to a healthy kidney (3). Multiple risk factors have been reported to predispose individuals to CKD or the progression of the disease, the most significant of which are African-American race, male gender, age over 60, positive family history, smoking, obesity, underlying diseases like diabetes mellitus (DM) and hypertension, and infectious agents like hepatitis B virus (HBV), human immunodeficiency virus (HIV), human T-lymphotropic virus 1 (HTLV-1), and hepatitis C virus (HCV) (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus and Its Occult Infection in Hemodialysis Patients

Nakhaie,

Taheri,

Charostad

et al. 2023

Jundishapur J Microbiol

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Background: Hepatitis C virus (HCV) is one of the most common infections in hemodialysis patients, which has been associated with increased incidence of morbidity and mortality, particularly in low- and middle-income countries. Objectives: The current study aimed to evaluate the HCV antibody, occult HCV infection (OCI), and related risk factors among hemodialysis patients. Methods: In this cross-sectional study, 100 hemodialysis patients referred to a dialysis center in Kerman between December 2021 and March 2022 were assessed for HCV, OCI, and their related risk factors. The information related to risk factors was collected by questionnaire, while HCV and OCI were detected through serology and real-time polymerase chain reaction (PCR) methods, respectively. Results: Among the patients participating in the study, 61 were men, and 39 were women. The average age was 58.1 ± 14.9 years in men and 63.6 ± 11.4 years in women. Diabetes and hypertension history, old age, low education, self-employment, and urban living were more common in chronic kidney disease patients. The enzyme-linked immunosorbent assay (ELISA) revealed 3% positive seroprevalence HCV infection, but only 1% was positive for OCI. Although no statistically significant relationship was found between the presence of HCV (antibody and OCI) and other parameters, all positive HCV cases were identified in patients with low education and freelance employment. Conclusions: Hemodialysis patients had a low prevalence of HCV antibody and OCI. Improving various factors and conditions such as lifestyle, occupation, educational level, and dialysis ward and machine disinfection could be beneficial in managing and controlling hemodialysis complications such as HCV and OCI.

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Risk factors for HTLV‐1, acute kidney injury, and urinary tract infection among aboriginal adults with end stage kidney disease in central Australia

Abstract: Central Australia is a human T-cell leukemia virus type 1c (HTLV-1c) endemic region and has the highest incidence of chronic kidney disease (CKD) in Australia.

Cited by 7 publications

References 41 publications

Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

Prevalence of Hepatitis C Virus and Its Occult Infection in Hemodialysis Patients

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