Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

Benencio, Paula; Ducasa, Nicolás; Arruvito, Lourdes; Irurzun, Inés; Praino, Laura; Lamberti, Magdalena; Beraza, María; Berini, Carolina Andrea; Biglione, Mirna

doi:10.3389/fmed.2021.758352

Cited by 3 publications

(2 citation statements)

References 33 publications

(41 reference statements)

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“…Several less crippling (yet are public health burden) disorders (including dermatitis and uveitis) are also associated with HTLV-1 (60)(61)(62). Infectious dermatitis is drawing clinical attention due to its manifestation among children and because it could develop into ATL or HAM/TSP later (63,64). Overall, about 10% of HTLV-1 infections lead to multiple diseases.…”

Section: A Challenge To the Prevailing Dogma: One Gene Sequence!one P...mentioning

confidence: 99%

Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective

Gallo

Tagaya

2022

Front. Immunol.

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The report is not a review or a summary. In a manner, it is a perspective but an unusual one. It looks back to the years my colleagues and I (RG) began preparing for human retroviruses (beginning in 1970), how they evolved, and attempts to bring to light or simply to emphasize many exceptional characteristics of a retrovirus known as HTLV-1 and some fortuitous coincidences, with emphasis on the needs of the field. These events cover over one half a century. We have had many reviews on HTLV-1 disease, epidemiology, and basic aspects of its replication, genome, gene functions, structure, and pathogenesis, though continued updates are needed. However, some of its truly exceptional features have not been highlighted, or at least not in a comprehensive manner. This article attempts to do so.

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Section: A Challenge To the Prevailing Dogma: One Gene Sequence!one P...mentioning

confidence: 99%

Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective

Gallo

Tagaya

2022

Front. Immunol.

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“…In addition, the northwest is the region with higher incidence for HAM/TSP ( 22 , 23 ). Although the disease burden due to HTLV-1 is unknown, in our country, cases of ATL are diagnosed annually and cases of infectious dermatitis have been reported ( 24 – 26 ). In people living with HIV, it has been reported a prevalence for HTLV-1/2 between 11 and 19% since 1990, actually a decline has been observed ( 27 – 32 ).…”

Section: Introductionmentioning

confidence: 99%

Making Visible HTLV Infection in a Non-endemic Area of Argentina

et al. 2022

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In Argentina, the human T-cell lymphotropic virus type 1 (HTLV-1) infection has been documented mainly among blood banks with a prevalence of ~0.02–0.046% for Buenos Aires city, 0.8% for the northeast, and 1% for the northwest; both areas are considered endemic for HTLV-2 and 1, respectively. Policies and specific guidelines for testing blood donors for HTLV are included since 2005. Screening for antibodies is performed at blood banks and confirmatory testing is performed at reference laboratories. There are no specific recommendations for the assistance of communities and individuals affected, nor referral to specialized clinics on the HTLV infection. In 2016, as a strategy of intervention, we opened a specialized clinical attendance in a referral infectious diseases public hospital for the comprehensive approach to patients with HTLV, offering follow-up and counseling for patients and their families for the early diagnosis of HTLV-1/2 and related diseases. During the study, 124 patients with presumptive HTLV positive diagnosis from blood bank, symptomatic patients (SPs), relatives, and descendants visited the unit. A total of 46 patients were HTLV positive (38 HTLV-1 and 8 HTLV-2). There were nine SPs (2 adult T-cell leukemia/lymphoma [ATL] and 7 HTLV-1-associated myelopathy/tropical spastic paraparesis [HAM/TSP]). All patients with HTLV-1 and−2 were offered to study their relatives. Two out of 37 (5.4%) descendants tested were positive for HTLV-1. Sexual partners were studied; among 6 out of 11 couples (54.5%) were found positive (5 HTLV-1 and 1 HTLV-2). Other relatives, such as mothers (1/2) and siblings (1/6), were positive for HTLV-1. According to the place of birth among HTLV-1 carriers, 58% were born in an endemic area or in countries where HTLV infection is considered endemic while for HTLV-2 carriers, 12.5% were born in an endemic area of Argentina. The proviral load (pVL) was measured in all, patients with HTLV-1 being higher in symptomatic compared with asymptomatic carriers. In addition, two pregnant women were early diagnosed during their puerperium and breastmilk replacement by formula was indicated. Inhibition of lactation was also indicated. Our study provides tools for a multidisciplinary approach to the infection and reinforces the importance of having specialized clinical units in neglected diseases, such as HTLV for counseling, clinical and laboratory follow-up, and providing useful information for patients for self-care and that of their families.

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Infective dermatitis associated with human T-cell lymphotropic virus type-1, an underdiagnosed disease

Bittencourt,

Farre

2024

International Journal of Infectious Diseases

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Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

Cited by 3 publications

References 33 publications

Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective

Reflections on Some of the Exceptional Features of HTLV-1 and HTLV-1 Research: A Perspective

Making Visible HTLV Infection in a Non-endemic Area of Argentina

Infective dermatitis associated with human T-cell lymphotropic virus type-1, an underdiagnosed disease

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