Risk factors for hepatitis B and C in multi-transfused patients in Uruguay

López, Lilia; López, Patricia; Arago, Antonio; Rodríguez, Ismael; López, Jorge Elias Torres; Lima, E de A; Insagaray, Juan; Bentancor, Nilo

doi:10.1016/s1386-6532(05)80037-x

Cited by 27 publications

(20 citation statements)

References 30 publications

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“…common than HCV in hemodialysis units (8)(9)(10)(11) due to routine screening, vaccination programs, infection control measures for HBV (12,13) and higher rates of viral clearance.…”

Section: Interprétationmentioning

confidence: 99%

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow-up after a Possible Breach in Hemodialysis Machines

Buxton

Whitlock

et al. 2009

Canadian Journal of Infectious Diseases and Medical Microbiolog

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BACKGROUND: A possible breach of the transducer protector in specific dialysis machines was reported in June 2004 in British Columbia (BC), which led to testing of hemodialysis patients for hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. This testing provided an opportunity to examine HCV incidence, prevalence and coinfection with HBV and HIV, and to compare anti-HCV and HCV polymerase chain reaction (PCR).METHODS: The results of hemodialysis patients who were dialyzed on the implicated machines (65% of BC dialysis patients), and tested for HCV, HBV and HIV, between June 1, 2004, and December 31, 2004, were reviewed and compared with available previous results.RESULTS: Of 1286 hemodialysis patients with anti-HCV and/or HCV-PCR testing, 69 (5.4%) tested positive. Two HCV genotype 4 seroconversions were identified. HCV incidence rate on dialysis was 78.8 cases per 100,000 person-years. Younger age, history of renal transplant and past HBV infection were associated with HCV infection. No occult infection was identified using HCV-PCR.INTERPRETATION: Hemodialysis patients had three times the HCV prevalence rate of the general BC population, and more than 20 times the incident rate of the general Canadian population. One of the two seroconversions occurred before the testing campaign; the patient was likely infected during hemodialysis in South Asia. The other was plausibly a late seroconversion following renal transplant in South Asia. Nosocomial transmission cannot be ruled out because both patients were dialyzed in the same centre. Baseline and annual anti-HCV testing is recommended. HCV-PCR should be considered at baseline for persons with HCV risk factors, and for returning travellers who received dialysis in HCV-endemic countries to identify HCV infection occurring outside the hemodialysis unit.

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“…common than HCV in hemodialysis units (8)(9)(10)(11) due to routine screening, vaccination programs, infection control measures for HBV (12,13) and higher rates of viral clearance.…”

Section: Interprétationmentioning

confidence: 99%

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow-up after a Possible Breach in Hemodialysis Machines

Buxton

Whitlock

et al. 2009

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…4 A lot of studies among multi-transfused thalassaemia patients reported the prevalence of HCV in β-thalassaemia patients at a wide range of 3−67%. [5][6][7][8][9] Mean age, duration and mean amount of blood transfused have been associated with an increased risk of HCV infection in β-thalassaemia patients. A study in Dhaka Shishu (Children) Hospital showed that the prevalence of HCV infection in β-thalassaemia patients was 18.5%.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Infection in Multi-transfused Thalassaemia Patients in Bangladesh

et al. 2018

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“…This would be expected in regions where carrier rates for chronic B infection range from 10 to 20 %. However, previous studies in Uruguay have found a high prevalence of HBV serologic markers in the population with risk factors (intravenous drug addicts, chronic dialysis patients) that approaches this rate [2,3]. Recombination is an important factor contributing to the genetic variability of HBV [65,66].…”

Section: Discussionmentioning

confidence: 99%

“…& Laura Garcia-Aguirre lgarcia@cin.edu.uy found in drug addicts, multitransfused patients (including hemophiliacs), and dialysis patients [2,3]. HBV has a high degree of genetic variation [4,5] and has been classified into eight groups (genotypes A-H) deduced from complete genome sequence comparisons [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

López¹,

Flichman

Mojsiejczuk

et al. 2015

Arch Virol

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Hepatitis B virus (HBV) infection is a serious global health problem. Approximately 2 billion people worldwide have been infected, and approximately 350 million individuals currently suffer from HBV-induced chronic liver infection, which causes 600,000 deaths annually from chronic hepatitis, cirrhosis and hepatocellular carcinoma. HBV is classified in eight genotypes (A-H), and two more have been proposed (I-J). In this paper, complete genome sequences of nine Uruguayan HBV are reported. Five samples belong to genotype F1b and one to genotype A2. Three HBV recombinants were detected: A1/F1b, A2/F1b and D3/F1b. The following mutations were detected: a G1896A substitution, a 33-nucleotide deletion from position 2896 to 2928 in the Pre-S1 region involving Pre-S1 residues 3-13, a 33-nt deletion in the Pre-S1 region involving nt 2913-2945 and Pre-S1 residues 9-19. More F genotypes strains than expected were detected in this study, supporting the hypothesis that there are more people of indigenous origin than declared in our population. Also, one third of the samples analyzed were recombinants. This cannot be explained by the low HBV prevalence in Uruguay, but a high HBV infection rate in drug addicts and dialysis patients could act in favor of multiple-genotype HBV infections that could lead to recombination.

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Risk factors for hepatitis B and C in multi-transfused patients in Uruguay

Cited by 27 publications

References 30 publications

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow-up after a Possible Breach in Hemodialysis Machines

Prevalence and Incidence of Hepatitis C Virus in Hemodialysis Patients in British Columbia: Follow-up after a Possible Breach in Hemodialysis Machines

Prevalence of Hepatitis C Virus Infection in Multi-transfused Thalassaemia Patients in Bangladesh

Genetic variability of hepatitis B virus in Uruguay: D/F, A/F genotype recombinants

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