Risk factors for early death in non-insulin dependent diabetes and men with known glucose tolerance status.

Balkau, Beverley; Eschwège, E; Papoz, L; Richard, Jean-Louis; Claude, Jean‐Roger; Warnet, J. M.; Ducimetière, Pierre

doi:10.1136/bmj.307.6899.295

Cited by 98 publications

(55 citation statements)

References 21 publications

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“…In agreement with previous studies [1][2][3][4][5][6][7], age-sex adjusted mortality rates were twice as high in diabetic subjects as in those with normal glucose tolerance, Fig. 1.…”

Section: Discussionsupporting

confidence: 81%

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Glucose tolerance and mortality, including a substudy of tolbutamide treatment

et al. 1997

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“…In agreement with previous studies [1][2][3][4][5][6][7], age-sex adjusted mortality rates were twice as high in diabetic subjects as in those with normal glucose tolerance, Fig. 1.…”

Section: Discussionsupporting

confidence: 81%

“…Thus hyperglycaemia predicts mortality rates regardless of the particular scheme used to classify hyperglycaemia [1][2][3][4][5][6][7]17]. A subset of 147 men with abnormal glucose tolerance by Brandt criteria were randomly assigned to treatment with or without tolbutamide.…”

Section: Discussionmentioning

confidence: 99%

Glucose tolerance and mortality, including a substudy of tolbutamide treatment

et al. 1997

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“…Findings in those that have are inconsistent. Several analyses have reported similar associations between total cholesterol or LDL-cholesterol and cardiovascular outcomes in patients with and without diabetes [2,4,11,12]. However, in the largest analysis conducted to date [3], the relationship between total cholesterol and risk of CVD in people with diabetes was reported to be weaker than that among individuals without diabetes (13 vs 28% excess risk of CVD associated with a 1 mmol/l increase in the level of total cholesterol), although it is not clear whether this difference was statistically significant.…”

Section: Discussionmentioning

confidence: 98%

Cholesterol, diabetes and major cardiovascular diseases in the Asia-Pacific region

2007

Diabetologia

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Aims/hypothesis The aim of this study was to assess the association between total cholesterol and major cardiovascular diseases among persons with and without diabetes in the Asia-Pacific region. Methods We used data on individual participants in 30 cohort studies from the Asia-Pacific region to compute the hazards ratios and 95% CIs for participants with and without diabetes at baseline, using Cox proportional models. Analyses were stratified by sex and region (Asia vs Australia or New Zealand) and adjusted for age. Repeat measurements of total cholesterol were used to adjust for regression dilution bias. Results The analysis included 333,533 individuals (6.3% with diabetes at baseline) who experienced 6,074 fatal and non-fatal cardiovascular events over a median follow-up period of 4.0 years. Total cholesterol was positively associated with coronary heart disease (CHD) and ischaemic stroke, and negatively with haemorrhagic stroke in a continuous, log-linear fashion, similarly among participants with and without diabetes. Each 1 mmol/l increase above the 'usual' level for total cholesterol was associated with a 41% (95% CI 23-63%) and 42% (95% CI 35-50%) greater risk of CHD among participants with and without diabetes. The corresponding values for ischaemic stroke were 23% (95% CI 0-52%) and 31% (95% CI 20-44%), respectively. These results were broadly consistent for sex, age and region. Conclusions/interpretation Total cholesterol is associated with similarly increased risks of cardiovascular events in people with and without diabetes. While abnormal levels of other lipid fractions are frequently observed in people with diabetes, these data support aggressive lowering of total cholesterol and LDL-cholesterol levels for prevention of cardiovascular events.

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“…A cute hyperglycemia after a meal or glucose load may be an independent predictor of vascular event rates in type 2 diabetes or impaired glucose tolerance (1)(2)(3)(4). One possible mechanism for such a relationship is increased generation of reactive oxygen species during acute hyperglycemia, leading to acute oxidative damage to the vascular endothelium, cell membranes, and lipoprotein components (5).…”

mentioning

confidence: 99%

Plasma F2 Isoprostanes

et al. 2002

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OBJECTIVE -Acute hyperglycemia in type 2 diabetes increases the generation of plasma 8-epi-prostaglandin F 2 (8-epi-PGF 2␣ ) isoprostane, a sensitive direct marker of in vivo free radical oxidative damage to membrane phospholipids. CONCLUSIONS -Plasma concentrations of 8-epi-PGF 2␣ isoprostane increase during acute hyperglycemia in type 2 diabetes, providing direct evidence of free radical-mediated oxidative damage and demonstrating a pathway for an association between acute rather than fasting hyperglycemia and macrovascular risk in type 2 diabetes. RESEARCH DESIGN AND METHODS

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Risk factors for early death in non-insulin dependent diabetes and men with known glucose tolerance status.

Cited by 98 publications

References 21 publications

Glucose tolerance and mortality, including a substudy of tolbutamide treatment

Glucose tolerance and mortality, including a substudy of tolbutamide treatment

Cholesterol, diabetes and major cardiovascular diseases in the Asia-Pacific region

Plasma F2 Isoprostanes

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