OBJECTIVE -Acute hyperglycemia in type 2 diabetes increases the generation of plasma 8-epi-prostaglandin F 2 (8-epi-PGF 2␣ ) isoprostane, a sensitive direct marker of in vivo free radical oxidative damage to membrane phospholipids. CONCLUSIONS -Plasma concentrations of 8-epi-PGF 2␣ isoprostane increase during acute hyperglycemia in type 2 diabetes, providing direct evidence of free radical-mediated oxidative damage and demonstrating a pathway for an association between acute rather than fasting hyperglycemia and macrovascular risk in type 2 diabetes. RESEARCH DESIGN AND METHODS

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