Risk factors for drug resistance in pulmonary tuberculosis inpatients

Yang, Xiaoyan; Liu, You‐Ping; Xiao, Wen; Wu, Guihui; Xi, Li

doi:10.1111/j.1756-5391.2010.01088.x

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…Previous TB treatment, a well-known risk factor for drug-resistant TB [7] [9]- [11] [14] [15] was also found to be significantly associated with drug resistance in the present study. Although drug-resistant TB can be transmitted between individuals (primary resistance), most cases arise after inadequate treatment allowing a drug-resistant strain to become dominant [10].…”

Section: Discussionsupporting

confidence: 63%

“…International studies have identified various risk factors for drug-resistant TB; these include previous TB treatment, poor adherence to treatment regimens, inadequate regimens and positive smear result at the end of the second and third month of treatment [7]- [17]. In addition of these programmatic factors, patients characteristics such as HIV co-infection, alcohol abuse and younger age [7]- [14] are also believe to influence the drug resistance.…”

Section: Introductionmentioning

confidence: 99%

“…In addition of these programmatic factors, patients characteristics such as HIV co-infection, alcohol abuse and younger age [7]- [14] are also believe to influence the drug resistance. However, information available on some of these issues is limited and controversial.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk Factors for Drug-Resistant Tuberculosis

Gomes¹,

Correia²,

Mendonça³

et al. 2014

JTR

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Drug-Resistant Tuberculosis

Gomes¹,

Correia²,

Mendonça³

et al. 2014

JTR

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“…Previous studies have shown that inadequate treatment of MDR-TB is a severe problem in China, particularly in hospitals [5,24]. Thus, it has become a common belief that patients who have a previous history of anti-TB treatment are most likely to develop drug resistance [13,25–27]. This study confirmed that the risk of developing MDR-TB was 2 to 11 times higher amongst TB patients who were in the five high-risk groups than amongst patients who were not.…”

Section: Discussionmentioning

confidence: 99%

High-risk screening and detection of multidrug-resistant tuberculosis in two prefectures of China: a drug susceptibility surveillance-based secondary data analysis

Yang

Zhou

Ning

et al. 2018

Global Health Action

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Background: In China, less than one-fifth of multidrug-resistant tuberculosis (MDR-TB) cases are detected. MDR-TB screening is conducted amongst the following five high-risk groups of TB patients: chronic cases, close contacts of MDR-TB patients, patients with treatment failure, relapsed and returned patients, and smear-positive patients at the end of the third month of initial treatment. Objective: To estimate the possibility of detecting MDR-TB cases if only the high-risk screening strategy is applied in China. Methods: A secondary analysis was applied to the surveillance-based longitudinal data of all sputum smear-positive TB patients in Prefecture E and Prefecture W of China from 2013 to 2015. The population attributable risk (PAR) was estimated using odds ratios for five risk factors/predictors and exposure proportions amongst all MDR-TB cases. Results: A total of 3513 TB patients (2807 from Prefecture E and 706 from Prefecture W) were included. Males accounted for 77.91% (2737/3513) of the patients. The average age was 52.5 ± 20.0 years old. Overall, 40.34% (71/176) of MDR-TB patients were from the five high-risk groups during the three-year study period. The detected proportion of MDR-TB cases using the high-risk screening strategy was significantly higher in Prefecture E than in Prefecture W. The PAR% for all five risk factors/predictors was 43.4% (95% CI: 24.6–61.7%), 49.9% (95% CI: 31.3–67.0%), and 30.3% (95% CI: 12.9–50.1%) in Prefecture E and 36.6% (95% CI: 10.4–64.5%), 13.3% (95% CI: −1.7–39.7%), and −82.5% (95% CI: −117.5–−11.2%) in Prefecture W in 2013, 2014, and 2015, respectively. The PAR% for the five specific risk factors/predictors ranged from 0.4% (95% CI: −0.2–4.8%) to 21.0% (95% CI: 13.1–30.0%) in these two prefectures. Conclusion: In general, a high-risk screening strategy would miss more than half of the MDR-TB patients because they do not belong to the five high-risk groups.

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“…While repeated inadequate tuberculosis (TB) treatment courses represent the most important risk factor for developing MDR-TB, new patients may also be diagnosed with MDR-TB as a result of the transmission of resistant strains 2 . Late diagnosis, as a consequence of limited access to diagnostic services, and the poor socioeconomic conditions of many patients are factors that contribute to the development of resistant strains 3 …”

Section: Introductionmentioning

confidence: 99%

Primary multidrug-resistant tuberculosis and its control implications in the State of Amazonas, Brazil: report of 3 cases

Garrido

Talhari

Antunes

et al. 2012

Rev. Soc. Bras. Med. Trop.

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The occurrence of tuberculosis with first-line multidrug resistance leads to the use of alternative medications, often at higher costs, longer treatment periods, and greater clinical complexity. Here, we report 3 patients with multidrug-resistant tuberculosis. One patient with human immunodeficiency virus died before the sensitivity test was performed. The early diagnosis of multidrug-resistant tuberculosis and appropriate treatment should be priorities of the National Tuberculosis Control Program in order to break the chain of transmission. In addition, the possibility of substituting the proportion method with more modern and faster techniques should be urgently evaluated.

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Risk factors for drug resistance in pulmonary tuberculosis inpatients

Cited by 6 publications

References 7 publications

Risk Factors for Drug-Resistant Tuberculosis

Risk Factors for Drug-Resistant Tuberculosis

High-risk screening and detection of multidrug-resistant tuberculosis in two prefectures of China: a drug susceptibility surveillance-based secondary data analysis

Primary multidrug-resistant tuberculosis and its control implications in the State of Amazonas, Brazil: report of 3 cases

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