Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997–2004)

Parsons, Corrina Snook; Orsini, James A.; Krafty, Robert T.; Capewell, Linda; Boston, Ray

doi:10.2460/javma.230.6.885

Cited by 123 publications

(89 citation statements)

References 17 publications

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“…A weak immune response due to a strong stress syndrome increases substantially the lethality rate [9]. Complications of equine acute colitis such as the laminitis or thrombophlebitis also worsen the prognosis [20,21].…”

Section: Discussionmentioning

confidence: 99%

Survival and Evaluation of Clinical and Laboratory Variables as Prognostic Indicators in Horses Hospitilized with Acute Diarrhea: 342 Cases (1995-2015)

Kovač́

Huskamp²,

Scheidemann³

et al. 2017

Acta Veterinaria

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A retrospective study was performed on 342 horses with acute diarrhea (equine colitis). Clinical and laboratory data were obtained upon arrival at the equine hospital. The main focus of this study was to fi nd the difference between the clinical and laboratory variables of surviving and deceased acute colitis horses before the beginning of medical treatment, with the aim to provide a better guideline for determining the prognosis of survival.According to this retrospective study the lethality rate of acute equine colitis was 41.93 %. The time interval from the onset of acute diarrhea to the horse being taken to the clinic was signifi cantly longer in the case of horses which had not survived. The heart rate, hematocrit, blood pH, blood hydrogen carbonate concentration, base excess and HCT/TPP ratio were shown to be signifi cantly related to the survival of horses with colitis. Thus, the hematocrit, appeared to be the most relevant predictor of the outcome of acute equine colitis. Body temperature, respiration rate, total plasma protein and white blood cell count, did not show any prognostic signifi cance.

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Section: Discussionmentioning

confidence: 99%

Survival and Evaluation of Clinical and Laboratory Variables as Prognostic Indicators in Horses Hospitilized with Acute Diarrhea: 342 Cases (1995-2015)

Kovač́

Huskamp²,

Scheidemann³

et al. 2017

Acta Veterinaria

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“…On the other hand, the signals may vary according with the stage where the disease is located. The prodromal phase includes the development of lesions in laminar tissue of the hoof, displaying subtle clinical signs, such as increased digital pulse and changes associated with sepsis as congested mucous membranes, tachycardia, increased capillary refill time, anorexia, hyperthermia and intestinal motility reduction (POLLITT, 1999;PARSONS et al, 2007).…”

Section: Clinical Signsmentioning

confidence: 99%

An update on equine laminitis

et al. 2016

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“…The study of laminitis, using clinical cases of horses affected by natural gastrointestinal disorders was also carried out by Steelman et al (2014), even if there are relevant variations between the causes of the diseases and clinical evolution of the patients. Horses with colic syndrome can develop sepsis (Parsons et al 2007, Wylie et al 2012) that can result in oxidative damage in organs distant from the intestinal damage, causing multiple organ failure (Fink 2002, Galley 2010, Alkharfy et al 2015. Epstein et al (2011) determined that around 30% of horses undergoing treatment of colic may develop SIRS, with symptoms including tachycardia, tachypnea, leukocytosis or leukopenia.…”

Section: Immunostaining For Sodmentioning

confidence: 99%

“…Laminitis is a severe podal disorder which affects horses and occurs commonly secondary to other inflammatory diseases with systemic implication, such as the colic syndrome (Parsons et al 2007), or in horses showing endocrinopathic changes, such as pituitary pars intermedia dysfunction (PPID) (Johnson et al 2002). Horses suffering from colic syndrome and PPID can show laminar lesions even without clinical signs of laminitis (Laskoski et al 2009, Laskoski et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Laminar lesions in horses with systemic oxidative stress, committed by experimentally induced or naturally occurring gastrointestinal disorders

et al. 2016

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Laminitis in horses can be associated with lesions in multiple organs secondary to sepsis. Twenty-one horses suffering from gastrointestinal disorders were used in the experiment; 7 horses with experimentally induced endotoxemia and intestinal ischaemia, and 14 horses suffering from naturally occurring colic syndrome. Tissue samples of lungs, liver, heart, brain, cerebellum and hoof laminar tissue were collected for histopathological and oxidative stress evaluation using nitrotyrosine and superoxide dismutase (SOD2) immunostaining. The horses were divided into two groups: the non-oxidative lesions group (NOLG), with 7 horses showing weak immunostaining in lungs, liver and kidney, and the oxidative lesions group (OLG), with 14 horses showing immunostaining indicating systemic oxidative stress in multiple organs. The horses from OLG showed increase of laminar lesions and SOD2 immunostaining in multiple organs when compared to the horses from the NOLG. No differences were found ln regard to laminar immunostaining by nitrotyrosine and SOD2 between experimental groups. It was concluded that systemic oxidative stress can be associated with the development of laminar lesions, and that the laminar tissue does not respond to oxidative stress with increase of SOD as occurs in other organs.

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Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997–2004)

Cited by 123 publications

References 17 publications

Survival and Evaluation of Clinical and Laboratory Variables as Prognostic Indicators in Horses Hospitilized with Acute Diarrhea: 342 Cases (1995-2015)

Survival and Evaluation of Clinical and Laboratory Variables as Prognostic Indicators in Horses Hospitilized with Acute Diarrhea: 342 Cases (1995-2015)

An update on equine laminitis

Laminar lesions in horses with systemic oxidative stress, committed by experimentally induced or naturally occurring gastrointestinal disorders

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