Risk factors for coronary heart disease in women: a study in a brazilian population

Faria, E.C. de; Moraes, V.S.; Oliveira, Manuela; Varriano, Ana Augusta; Silva, C.A.M.; Castilho, Lísias Nogueira

doi:10.1016/s0021-9150(99)80388-8

Cited by 2 publications

(1 citation statement)

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“…CAD is the main cause of mortality in many parts of the industrialized world [ 26 ]. In Brazil, CAD is the major cause of mortality and morbidity in women over the age of 40 or 50 years [ 27 ]. Hence, the early identification of subjects at risk of developing CAD is an important public health issue.…”

Section: Introductionmentioning

confidence: 99%

The Roles of Genetic Polymorphisms and Human Immunodeficiency Virus Infection in Lipid Metabolism

Almeida

Reiche

Kallaur

et al. 2013

BioMed Research International

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Dyslipidemia has been frequently observed among individuals infected with human immunodeficiency virus type 1 (HIV-1), and factors related to HIV-1, the host, and antiretroviral therapy (ART) are involved in this phenomenon. This study reviews the roles of genetic polymorphisms, HIV-1 infection, and highly active antiretroviral therapy (HAART) in lipid metabolism. Lipid abnormalities can vary according to the HAART regimen, such as those with protease inhibitors (PIs). However, genetic factors may also be involved in dyslipidemia because not all patients receiving the same HAART regimen and with comparable demographic, virological, and immunological characteristics develop variations in the lipid profile. Polymorphisms in a large number of genes are involved in the synthesis of structural proteins, and enzymes related to lipid metabolism account for variations in the lipid profile of each individual. As some genetic polymorphisms may cause dyslipidemia, these allele variants should be investigated in HIV-1-infected patients to identify individuals with an increased risk of developing dyslipidemia during treatment with HAART, particularly during therapy with PIs. This knowledge may guide individualized treatment decisions and lead to the development of new therapeutic targets for the treatment of dyslipidemia in these patients.

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Section: Introductionmentioning

confidence: 99%