Risk factors for ciprofloxacin-resistant Campylobacter infection in Wales

Evans, Meirion Rhys; Northey, Gemma; Sarvotham, Tinnu; Hopkins, A. Lynne; Rigby, C.; Thomas, Daniel Rhys

doi:10.1093/jac/dkp179

Cited by 12 publications

(28 citation statements)

References 10 publications

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“…jejuni in Switzerland are less likely to have domestic chicken as a major source than infections with susceptible strains. This observation is consistent with the results of three case-control studies from Canada, Denmark and the United Kingdom where consumption of chicken has also been found not to be a risk factor for quinolone-resistant Campylobacter infection (Engberg et al 2004;Johnson et al 2008;Evans et al 2009). Nonetheless, 39% of the resistant human strains showed a full match with genotypes found in slaughtered chickens.…”

Section: Discussionsupporting

confidence: 91%

“…Thus, quinolone use at Swiss poultry farms might contribute to the increased resistance of human isolates; it seems, however, that there are other yet unknown factors. Foreign travel might be one explanation, as it has been recognized as a major risk factor for infections with quinolone-resistant strains in other industrialized countries (Engberg et al 2004;Johnson et al 2008;Evans et al 2009). This interpretation would correspond to the observation that the human isolates with genotypes other than those of the chicken isolates were rather diverse.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of genotypes and antibiotic resistance of Campylobacter jejuni isolated from humans and slaughtered chickens in Switzerland

Kittl

Kuhnert

Hächler

et al. 2010

Journal of Applied Microbiology

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Aims: To get an overview of genotypes and antibiotic resistances in Swiss Campylobacter jejuni implicated in human gastroenteritis and to examine the association with isolates from chickens. Methods and Results: Multilocus sequence typing (MLST) and flaB typing were applied to 136 human clinical isolates. Phenotypic resistance to 12 antimicrobials and genotypic resistance to macrolides and quinolones were determined. MLST resulted in 35 known and six new sequence types (ST). The flaB analysis revealed 35 different types, which – in combination with MLST – increased the resolution of the typing approach. Resistance to quinolones, tetracycline and ampicillin was found in 37·5, 33·1 and 8·1% of the isolates, respectively, whereas macrolide resistance was found only once. Genotypic and phenotypic resistance correlated in all cases. A comparison to Camp. jejuni isolated from slaughtered chickens was performed. While 86% of the quinolone‐sensitive human isolates showed overlapping MLST‐flaB types with those of chicken origin, resistant strains showed only 39% of matching types. Conclusion: Mainly quinolone‐sensitive Camp. jejuni strains implicated in human campylobacteriosis showed matching genotypes with isolates originating from chickens. Significance and Impact of the Study: A large proportion of human cases in Switzerland are likely to originate from domestic chickens, confirming that prevention measures in the poultry production are important.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of genotypes and antibiotic resistance of Campylobacter jejuni isolated from humans and slaughtered chickens in Switzerland

Kittl

Kuhnert

Hächler

et al. 2010

Journal of Applied Microbiology

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“…Grenada is a small island state far from the US, UK, Europe, and Asia, and resistant Campylobacter strain emergence in Grenada could contribute to resistance globally. It has been noted that foreign travel is a risk factor for fluoroquinolone-resistant campylobacteriosis [54–56]. Furthermore, in popular European travel destinations, both fluoroquinolone and tetracycline resistance among poultry isolates is higher than in other locations [57].…”

Section: Discussionmentioning

confidence: 99%

MLST Genotypes and Antibiotic Resistance ofCampylobacterspp. Isolated from Poultry in Grenada

Stone

Davis

Baker

et al. 2013

BioMed Research International

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This study determined whether multilocus sequence types (MLST) of Campylobacter from poultry in 2 farms in Grenada, West Indies, differed by farm, antimicrobial resistance and farm antibiotic use. Farm A used fluoroquinolones in the water and Farm B used tetracyclines. The E-test was used to determine resistance of isolates to seven antibiotics. PCR of the IpxA gene confirmed species and MLST was used to characterize 38 isolates. All isolates were either C. jejuni or C. coli. Farm antibiotic use directly correlated with antimicrobial resistance of Campylobacter isolates. Almost 80% of the isolates from Farm A were fluoroquinolone resistant and 17.9% of the isolates from Farm B were fluoroquinolone resistant. All Campylobacter isolates from Farm A were tetracycline sensitive, whereas 35.7% of isolates from Farm B were tetracycline resistant. Six previously recognized sequence types (STs) and 2 novel STs were identified. Previously recognized STs were those overwhelmingly reported from poultry and humans globally. Isolates with the same ST did not always have the same antibiotic resistance profile. There was little ST overlap between the farms suggesting that within-farm transmission of Campylobacter genotypes may dominate. MLST typing was useful for tracking Campylobacter spp. among poultry units and can help elucidate Campylobacter host-species population structure and its relevance to human health.

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“…In The Netherlands (16·5 million population), an estimated 90 000 cases of campylobacteriosis occur annually, with ∼12% estimated as international travel-related [4]. Moreover, fluoroquinolone-resistant Campylobacter infections occur significantly more often in travel-related cases [3, 5].…”

Section: Introductionmentioning

confidence: 99%

Campylobacteriosis in returning travellers and potential secondary transmission of exotic strains

et al. 2013

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Multilocus sequence types (STs) were determined for 232 and 737 Campylobacter jejuni/coli isolates from Dutch travellers and domestically acquired cases, respectively. Putative risk factors for travel-related campylobacteriosis, and for domestically acquired campylobacteriosis caused by exotic STs (putatively carried by returning travellers), were investigated. Travelling to Asia, Africa, Latin America and the Caribbean, and Southern Europe significantly increased the risk of acquiring campylobacteriosis compared to travelling within Western Europe. Besides eating chicken, using antacids, and having chronic enteropathies, we identified eating vegetable salad outside Europe, drinking bottled water in high-risk destinations, and handling/eating undercooked pork as possible risk factors for travel-related campylobacteriosis. Factors associated with domestically acquired campylobacteriosis caused by exotic STs involved predominantly person-to-person contacts around popular holiday periods. We concluded that putative determinants of travel-related campylobacteriosis differ from those of domestically acquired infections and that returning travellers may carry several exotic strains that might subsequently spread to domestic populations even through limited person-to-person transmission.

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Risk factors for ciprofloxacin-resistant Campylobacter infection in Wales

Abstract: Foreign travel remains the most important risk factor for ciprofloxacin-resistant Campylobacter infection. The possible association of both domestic- and travel-related ciprofloxacin-resistant Campylobacter infection with bottled water needs to be further explored.

Cited by 12 publications

References 10 publications

Comparison of genotypes and antibiotic resistance of Campylobacter jejuni isolated from humans and slaughtered chickens in Switzerland

Comparison of genotypes and antibiotic resistance of Campylobacter jejuni isolated from humans and slaughtered chickens in Switzerland

MLST Genotypes and Antibiotic Resistance ofCampylobacterspp. Isolated from Poultry in Grenada

Campylobacteriosis in returning travellers and potential secondary transmission of exotic strains

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