Risk factors for chronic non-diseases and cardiovascular risk anthropometric indices: is there a correlation?

Abstract

Alkaptonuria is a rare autosomal recessive disorder caused by deficiency in homogentisate 1,2-dioxygenase, which leads to a tissue accumulation of homogentisic acid (HGA). HGA irreversibly deposits in connective tissues, which leads to degeneration of the articular cartilage, leaving these tissues with dark pigmentation, known as ochronosis. Alkaptonuria typically presents with a triad of homogentisic aciduria, ochronosis and ochronotic arthropathy during the third and fourth decade of life. The ochronotic arthropathy is the most impactful complication in the quality of life, even though it virtually impacts every system. There is no effective treatment, so intervention is based on symptoms, maintaining function and pain control while the inevitable deterioration of weightbearing joints progresses. Almost all patients are submitted to arthroplasties of the knee and/or hip. Soon there might be a way to prevent complications, has there are ongoing phase 3 studies to approve a drug that blocks the formation of HGA.

Risk factors for chronic non-diseases and cardiovascular risk anthropometric indices: is there a correlation?

“…12 Regarding the WC and WHtR variables, in a study with 685 adults and 1.020 elderly people, in the adult population, with these indices above the classification, they also showed an average of altered triglycerides and cholesterol, as with the Institution's employees, most of them had moderate to high risk in WC and WHtR, most of them have some degree of excess weight, which contributes to the increase in abdominal adipose tissue, related to metabolic imbalance and lipid profile. 13 CP evaluates excess weight as visceral fat and upper subcutaneous fat in the neck region, having its CP values increased, and there is the manifestation of fat on the walls of the carotid arteries, triggering CVD and insulin resistance. With this, it is possible to verify that 77.5% of employees can develop these diseases, as there are findings in which PC is directly related to blood glucose and lipid indicators, corroborating these comorbidities.…”