Risk Factors for Chronic Kidney Disease in Pediatric Patients with Epilepsy

Pak, Jun; Byeon, Jung Hye; Yim, Chung Hyuk; Eun, Baik-Lin

doi:10.26815/acn.2020.00213

Ann Child Neurol

2021

DOI: 10.26815/acn.2020.00213

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Risk Factors for Chronic Kidney Disease in Pediatric Patients with Epilepsy

Jun Pak

Jung Hye Byeon

Chung Hyuk Yim

et al.

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2023

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“…Sometimes AEDs may cause serious nephrotoxicity. Since these reactions are usually unpredictable, clinicians should be careful about this possibility [7].The main focus of epilepsy is a satisfying seizure control with minimum side effects [8]. Diazepam is a benzodiazepine.…”

mentioning

confidence: 99%

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Şaylan¹,

Turel²,

Türel³

et al. 2023

j-ebr

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To investigate the effects of diazepam, which has anticonvulsant and anxiolytic effects, and diclofenac potassium, which has anti-inflammatory, analgesic and antipyretic effects, on rat kidney tissue, used in an experimental epilepsy model. Methods: 32 Wistar albino rats (2-4 months old, 200-250 gr) were used in the study. The rats were grouped in four as 8 rats in each group: Epilepsy, Epilepsy + Diazepam, Epilepsy + Diclofenac potassium, Epilepsy + Diazepam + Diclofenac potassium. Epileptic seizure model was created with penicillin (500.000 IU) injected intracortically under urethane anesthesia. 30 minutes later, diazepam (0.1 mg/kg) and diclofenac potassium (10 mg/kg) were administered intraperitoneally. At the end of the study, rat kidneys were removed and evaluated histopathologically in terms of inflammation, glomerular shrinkage, tubular dilatation, tubular epithelial thinning, desquame epithelium, brush epithelial loss, vacuolization, hemorrhage and congestion. Results: No difference was found between diazepam and diclofenac potassium in terms of vacuolization, glomerular shrinkage, tubular dilatation and hemorrhage. Inflammation, congestion and tubular epithelial thinning rate were found to be lower inEpilepsy + Diclofenac potassium and Epilepsy + Diazepam + Diclofenac potassium group when compared with Epilepsy + Diazepam group. While brush epithelial loss and desquame epithelial rate was found to be lowest in the epilepsy group, these parameters were not found to show a significant difference between drug groups. Conclusion: It was concluded that combined use of diazepam and diclofenac potassium in their effects on kidney are more useful than their single use.

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mentioning

confidence: 99%

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Şaylan¹,

Turel²,

Türel³

et al. 2023

j-ebr

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Risk Factors for Chronic Kidney Disease in Pediatric Patients with Epilepsy

Cited by 1 publication

References 20 publications

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

Histopathological effects on kidney of diclofenac potassium and diazepam used in an experimental epilepsy model

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