Risk Factors for Central Serous Chorioretinopathy: Multivariate Approach in a Case-Control Study

Chatziralli, Irini; Kabanarou, Stamatina Α.; Parikakis, Efstratios; Chatzirallis, Alexandros; Xirou, Tina; Mitropoulos, Panagiotis

doi:10.1080/02713683.2016.1276196

Cited by 91 publications

(116 citation statements)

References 36 publications

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“…; Chatziralli et al. ), we did not find any evidence to support this. Critical evaluation of the available literature revealed that type A behavioural characteristics were mainly assessed using behavioural outcome measures (i.e.…”

Section: Discussioncontrasting

confidence: 86%

“…; Chatziralli et al. ). On the level of conduct, patients did not report more psychological morbidity in the form of apathy or irritability.…”

Section: Discussionmentioning

confidence: 98%

“…; Chatziralli et al. ), while this inventory has been shown not to correlate with personality characteristics and psychopathology (Wadden et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…; Chatziralli et al. ). The term ‘type A behaviour’ was introduced by Friedman & Rosenman () and was characterized as follows: an intense, sustained drive to achieve self‐selected but usually poorly defined goals, profound inclination and eagerness to compete, persistent desire for recognition and advancement, continuous involvement in multiple and diverse functions constantly subject to deadlines, habitual propensity to accelerate the rate of execution of many physical and mental functions, and extraordinary mental and physical alertness.…”

Section: Introductionmentioning

confidence: 98%

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Maladaptive personality traits, psychological morbidity and coping strategies in chronic central serous chorioretinopathy

Haalen

Dijk

Andela

et al. 2018

Acta Ophthalmologica

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Purpose ‘Type A’ behavioural characteristics and psychosocial stress have traditionally been associated with chronic central serous chorioretinopathy (cCSC). However, a characteristical personality profile could not be identified in these patients and the presumed association with stress is subject to controversy, due to a lack of convincing studies using validated measuring instruments. In this study, we aimed to assess maladaptive personality traits, psychological morbidity and coping strategies in patients with cCSC, in order to identify potentially modifiable psychosocial aspects which could be used in support to current standard treatment. Methods A cross‐sectional study in a cohort of 86 patients with cCSC using validated questionnaires. Findings were compared to both Dutch population reference data and reference data from patients treated for Cushing's disease. Results Maladaptive personality traits were not more prevalent in patients with cCSC than in the general population, and psychological morbidity was not increased. Patients with cCSC were shown to make more use of passive coping, active coping and seeking social support. Interestingly, personality, psychological morbidity and coping characteristics of patients with cCSC were more comparable to features of patients treated for Cushing's disease than to population‐based data. Conclusion Maladaptive personality traits such as type A behavioural characteristics are not more prevalent in patients with cCSC. Patients with cCSC make more use of certain coping strategies, which could be addressed by psychosocial care to improve self‐management. Further research is needed establish whether the course of disease can be improved by altering coping and reducing ‘stress’.

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Section: Discussioncontrasting

confidence: 86%

“…; Chatziralli et al. ). On the level of conduct, patients did not report more psychological morbidity in the form of apathy or irritability.…”

Section: Discussionmentioning

confidence: 98%

“…; Chatziralli et al. ), while this inventory has been shown not to correlate with personality characteristics and psychopathology (Wadden et al. ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Maladaptive personality traits, psychological morbidity and coping strategies in chronic central serous chorioretinopathy

Haalen

Dijk

Andela

et al. 2018

Acta Ophthalmologica

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“…Spaide et al asserted that nicotine exposure may cause nitric oxide-induced abnormalities of choroidal vessels and induce CSC 11 17 28. Myopia has been reported to be a protective factor17 29 and hyperopia a risk factor 17. Our study revealed that one dioptre hyperopic change in spherical equivalent refractive error increases, and one dioptre myopic change decreases, the odds of being a patient with CSC by 24.6%.…”

Section: Discussionmentioning

confidence: 49%

Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients

et al. 2018

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Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration

et al. 2023

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ImportanceCentral serous chorioretinopathy (CSC) is a serous maculopathy of unknown etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD. Improved understanding of CSC genetics may broaden our understanding of this genetic overlap and unveil mechanisms in both diseases.ObjectiveTo identify novel genetic risk factors for CSC and compare genetic risk factors for CSC and AMD.Design, Setting, and ParticipantsUsing International Classification of Diseases, Ninth (ICD-9) and Tenth (ICD-10) Revision code-based inclusion and exclusion criteria, patients with CSC and controls were identified in both the FinnGen study and the Estonian Biobank (EstBB). Also included in a meta-analysis were previously reported patients with chronic CSC and controls. Data were analyzed from March 1 to September 31, 2022.Main Outcomes and MeasuresGenome-wide association studies (GWASs) were performed in the biobank-based cohorts followed by a meta-analysis of all cohorts. The expression of genes prioritized by the polygenic priority score and nearest-gene methods were assessed in cultured choroidal endothelial cells and public ocular single-cell RNA sequencing data sets. The predictive utility of polygenic scores (PGSs) for CSC and AMD were evaluated in the FinnGen study.ResultsA total of 1176 patients with CSC and 526 787 controls (312 162 female [59.3%]) were included in this analysis: 552 patients with CSC and 343 461 controls were identified in the FinnGen study, 103 patients with CSC and 178 573 controls were identified in the EstBB, and 521 patients with chronic CSC and 3577 controls were included in a meta-analysis. Two previously reported CSC risk loci were replicated (near CFH and GATA5) and 3 novel loci were identified (near CD34/46, NOTCH4, and PREX1). The CFH and NOTCH4 loci were associated with AMD but in the opposite direction. Prioritized genes showed increased expression in cultured choroidal endothelial cells compared with other genes in the loci (median [IQR] of log 2 [counts per million], 7.3 [0.6] vs 4.7 [3.7]; P = .004) and were differentially expressed in choroidal vascular endothelial cells in single-cell RNA sequencing data (mean [SD] fold change, 2.05 [0.38] compared with other cell types; P &lt; 7.1 × 10−20). A PGS for AMD was predictive of reduced CSC risk (odds ratio, 0.76; 95% CI, 0.70-0.83 per +1 SD in AMD-PGS; P = 7.4 × 10−10). This association may have been mediated by loci containing complement genes.Conclusions and RelevanceIn this 3-cohort genetic association study, 5 genetic risk loci for CSC were identified, highlighting a likely role for genes involved in choroidal vascular function and complement regulation. Results suggest that polygenic AMD risk was associated with reduced risk of CSC and that this genetic overlap was largely due to loci containing complement genes.

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Risk Factors for Central Serous Chorioretinopathy: Multivariate Approach in a Case-Control Study

Abstract: It is important to take into account the various risk factors for CSR, so as to define vulnerable groups and to shed light into the pathogenesis of the disease.

Cited by 91 publications

References 36 publications

Maladaptive personality traits, psychological morbidity and coping strategies in chronic central serous chorioretinopathy

Maladaptive personality traits, psychological morbidity and coping strategies in chronic central serous chorioretinopathy

Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients

Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration

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