Risk factors for carbapenem-resistant Klebsiella pneumoniae infection/colonization: A case–case-control study

Kofteridis, Diamantis P.; Valachis, Antonis; Dimopoulou, Dimitra; Maraki, Sofia; Christidou, Athanasia; Mantadakis, Elpis; Samonis, George

doi:10.1016/j.jiac.2013.11.007

Cited by 56 publications

(62 citation statements)

References 34 publications

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“…Some studies found that antibiotic exposure was a risk factor for CRKP acquisition [8,12,17,18]. In contrast, other studies found that CRKP acquisition was not associated with prior antibiotic therapy [9,10,19]. These differences may be related to the high rate of antibiotic exposure during ICU stay among the total study population, making it very difficult to assess the impact of antibiotic exposure [17].…”

Section: Discussionmentioning

confidence: 96%

“…Several previous studies have assessed risk factors of CRKP infections among hospitalized patients, and ICU stay was found to be an independent risk factor [8,10,12,17,18]. ICUs are considered as the main source for multidrug-resistant bacteria spread.…”

Section: Discussionmentioning

confidence: 99%

“…Identification of risk factors for CRKP infection would facilitate the choice and the efficacy of empirical therapy [10], especially in intensive care unit (ICU) settings. The ICU has been described as a factory for creating, disseminating, and amplifying antimicrobial resistance due to its extremely vulnerable population of critically ill patients, the heavy use of invasive procedures, and the frequent application of antimicrobials [11].…”

Section: Introductionmentioning

confidence: 99%

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A retrospective study of risk factors for carbapenem-resistant Klebsiella pneumoniae acquisition among ICU patients

Ping

et al. 2016

J Infect Dev Ctries

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Introduction: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is rapidly emerging as a life-threatening nosocomial infection. In this study, we aim to identify risk factors, especially antibiotic use, for CRKP infection among intensive care unit (ICU) patients. Methodology: This was a matched case-control study of a 67-bed ICU in a tertiary care teaching hospital from 1 January 2011 through 30 June 2013. The control cases were selected among the patients with carbapenem-susceptible Klebsiella pneumoniae (CSKP) and were matched with CRKP cases for year of ICU admission and site of infection. The clinical outcomes and antibiotic treatments were analyzed. Results: One hundred and thirty patients were included in the study (65 cases and 65 controls). Bivariable analysis showed that age of patients (p = 0.044), number of antibiotic groups (p = 0.001), and exposure to carbapenems (p < 0.001) were associated with CRKP infection. Using multivariate analysis adjusted for age, prior hospitalization, number of antibiotic groups, and previous exposure to carbapenems, previous carbapenem exposure (p < 0.001) was identified as an independent risk factor for CRKP infection. Conclusions: These data suggest that exposure to carbapenems is an independent risk factor for CRKP infection. Patients with this clinical factor should be targeted for interventions to reduce the subsequent risk of infection.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A retrospective study of risk factors for carbapenem-resistant Klebsiella pneumoniae acquisition among ICU patients

Ping

et al. 2016

J Infect Dev Ctries

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“…[9][10][11] K. pneumoniae is commonly present in intensive care unit (ICU) as a species of Enterobacteriaceae, which is most prone to producing the enzyme associated with carbapenem resistance. 12 As treatment regimens suitable for CRKP infection/colonization are limited, epidemiological and microbiological studies on carbapenem-resistant Gramme-negative bacteria appear to be particularly important. Identifying risk factors for the development of CRKP acquisition is important for treatment options, and consequently, a number of risk factors for CRKP infection/colonization have been revealed in some retrospective clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for carbapenem-resistantKlebsiella pneumoniaeinfection/colonization and predictors of mortality: a retrospective study

Jiao

Qin

Liu

et al. 2015

Pathogens and Global Health

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Objective: To identify risk factors associated with carbapenem-resistant Klebsiella pneumoniae (CRKP) infection/colonization and death and to investigate the resistance and homology of CRKP. Methods: A retrospective 1:1 case-control study was conducted at Changhai Hospital, China, from January 2010 to December 2011.The study population included 30 patients with CRKP infection/colonization and 30 matched patients with carbapenem-susceptible K. pneumoniae (CSKP) infection/colonization at the same site. Homology analysis was conducted by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Potential resistance genes were detected by PCR. .026) were independent risk factors for the death of patients with K. pneumoniae infection/colonization. Older age (OR: 1.16, 95% CI: 1.01-1.39, P50.011) was an independent risk factor for the death of patients with CRKP infection/colonization. Thirty CRKP strains were all KPC-2-producing resistant strains with genotype of ST-11. Conclusion: Exposure to glycopeptides, cefoperazone plus sulbactam and tracheostomy were independent risk factors for CRKP infection/colonization, and older age was an independent risk factor for CRKP infection/ colonization caused death.

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“…Recent studies shed light on some risk factors for CR-Kp acquisition (5)(6)(7)(8). However, the importance of the prior use of antibiotics has been little investigated.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Carbapenem Resistant Klebsiella pneumoniae Hospital Infection in the Intensive Care Unit

Djordjevic

Folić

Gajovic

et al. 2018

Serbian Journal of Experimental and Clinical Research

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Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has become a major threat to patients in hospitals, increasing mortality, length of stay and costs. e aim of this study was to discover risk factors for the development of hospital infections (HIs) caused by CR-Kp. A prospective cohort study was conducted in the Medical-Surgical Intensive Care Unit of the Clinical Centre in Kragujevac, Kragujevac, Serbia, from January 1, 2011, to December 31, 2015 (OR=1.080; p=0.045); previous use of carbapenems (OR=7.005; p=0.044); previous use of ciprofl oxacin (OR=20.628; p=0.007) and previous use of metronidazole (OR=40.320; p=0.011 p=0.046), dužina primene antibiotske terapije pre nastanka bolničke infekcije (OR=1.080; p=0.045), prethodna upotreba karbapenema (OR=7.005; p=0.044), prethodna upotreba ciprofl oksacina (OR=20.628; p=0.007) i prethodna upotreba metronidazola (OR=40.320; p=0.011

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Risk factors for carbapenem-resistant Klebsiella pneumoniae infection/colonization: A case–case-control study

Cited by 56 publications

References 34 publications

A retrospective study of risk factors for carbapenem-resistant Klebsiella pneumoniae acquisition among ICU patients

A retrospective study of risk factors for carbapenem-resistant Klebsiella pneumoniae acquisition among ICU patients

Risk factors for carbapenem-resistantKlebsiella pneumoniaeinfection/colonization and predictors of mortality: a retrospective study

Risk Factors for Carbapenem Resistant Klebsiella pneumoniae Hospital Infection in the Intensive Care Unit

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